Blood Coagulation Factors

Vocabulary flashcards for blood coagulation factors, including their description and function.

Fibrinogen (Factor I)

MW=340,000 Da; glycoprotein; Adhesive protein that forms the fibrin clot

Prothrombin (Factor II)

MW=72,000 Da; vitamin K-dependent serine protease; Activated form is main enzyme of coagulation

Tissue factor (Factor III)

MW= 37,000 Da; also known as thromboplastin; Lipoprotein initiator of extrinsic pathway

Calcium ions (Factor IV)

Necessity of Ca ions for coagulation reactions described in 19th century; Metal cation necessary for coagulation reactions

Labile factor (Factor V)

MW 330,000 Da; Cofactor for activation of prothrombin to thrombin

Proconvertin (Factor VII)

MW 50,000 Da; vitamin K-dependent serine protease; With tissue factor, initiates extrinsic pathway

Antihemophilic factor (Factor VIII)

MW 330,000 Da; Cofactor for intrinsic activation of factor X

Christmas factor (Factor IX)

MW=55,000 Da; vitamin K-dependent serine protease; Activated form is enzyme for intrinsic activation of factor X

Stuart-prower factor (Factor X)

MW 58,900 Da; vitamin K-dependent serine protease; Activated form is enzyme for final common pathway activation of prothrombin. Activated form is intrinsic activator of factor IX