Clustering of membrane immunoglobulins and the B-cell receptor complex & The B-cell coreceptor

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4 Terms

1
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What is the role of Igα and Igβ in B-cell activation?

Igα and Igβ relay signals to the B-cell cytoplasm because immunoglobulin heavy and light chains have small cytoplasmic domains.

2
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How is B-cell activation initiated?

Immunoglobulin crosslinking or clustering on the B-cell surface initiates signaling events involved in activation.

3
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What is the B-cell coreceptor analogous to?

The B-cell coreceptor is analogous to the T-cell coreceptor CD28, which interacts with B7 on an APC.

4
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What are the components of the B-cell coreceptor?

The B-cell coreceptor is made of three polypeptides:

  • CR2

  • CD19

  • CD81