Studied by 1 person
Looks like no one added any tags here yet for you.
Regular Insulin Intake
Necessary for managing adult-onset diabetes, taken at specific time intervals.
Insulin from Other Animals
Isolation and use as a substitute for human insulin, potential immunological response in the human body.
Bacterial Production of Human Insulin
Simplifying the insulin production process, ability to produce large quantities easily.
Oral Administration of Insulin
Feasibility for diabetic individuals, reasons for current limitations.
Historical Source of Insulin
Extraction from cattle and pigs' pancreas, allergic reactions in some patients.
Structure of Insulin
Consists of two short polypeptide chains (chain A and chain B) linked by disulphide bridges.
Insulin Synthesis in Mammals
Synthesized as a pro-hormone with an extra stretch called the C peptide, removed during maturation into insulin.
Challenges in Insulin Production
Main challenge is getting insulin assembled into a mature form, Eli Lilly prepared DNA sequences for A and B chains of human insulin in 1983.
Production Process
Chains A and B produced separately, then combined to form human insulin by creating disulfide bonds.
Note 
Flashcard (53)