Antibody Diversity, Class Switching and Antigen Presentation

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Last updated 11:25 AM on 1/18/26
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10 Terms

1
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What is combinatorial diversity?

Different combinations of V, D and J segments

2
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What is junctional diversity?

Imprecise joining and nucleotide addition

3
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Which enzyme adds N nucleotides?

Terminal deoxynucleotidyl addition

4
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What proces increases affinity after activation?

Somatic hypermutation

5
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Which enzyme mediates SHM

Activation-induced deaminase (AID)

6
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Where does SHM occur?

Germinal centres

7
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What is class switching?

Changing antibody isotype without altering specificity

8
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Which antibody is produced first?

IgM

9
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Which MHC presents endogenous antigens?

MHC Class I

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Which MHC presents exogenous antigens?

MHC Class II