Antibody Diversity, Class Switching and Antigen Presentation
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10 Terms
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What is combinatorial diversity?
Different combinations of V, D and J segments
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What is junctional diversity?
Imprecise joining and nucleotide addition
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Which enzyme adds N nucleotides?
Terminal deoxynucleotidyl addition
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What proces increases affinity after activation?
Somatic hypermutation
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Which enzyme mediates SHM
Activation-induced deaminase (AID)
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Where does SHM occur?
Germinal centres
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What is class switching?
Changing antibody isotype without altering specificity
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Which antibody is produced first?
IgM
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Which MHC presents endogenous antigens?
MHC Class I
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Which MHC presents exogenous antigens?
MHC Class II
Note 
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