Fluoroquinolones
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10 Terms
What are the fluoroquinolones
Ciprofloxacin (Cipro) IV/PO
Levofloxacin (Levaquin) IV/PO
Moxifloxacin (Avelox) IV/PO
Delafloxacin (Baxdela) IV/PO
Fluoroquinolones MOA
inhibit bacterial topoisomerase
Ciprofloxacin dosing
400mg IV q12h
250-750mg po q12h
Levofloxacin dosing
250-750mg po q24h
Which fluroquinolone does not need to be renally adjusted
Moxifloxacin
Fluoroquinolones: Organisms
Moderate MSSA, strept, enterococcus (cipro poor G+)
most + pseudomonas (not moxi)
moxi has anaerobic
Atypicals
FDA Warning for Fluoroquinolones
CI with myasthenia gravis
Peripheral neuropathy
Neurotoxicity
Tendinitis/Tendon rupture
In what conditions can you use fluoroquinolones if there is no other alternative?
acute chronic bronchitis exacerbation
acute uncomplicated cystitis
acute sinusitis
Fluoroquinolones SE and Pearls
Hypoglycemia
moxi and levo are considered respiratory
photosensitivity
avoid cations
QT prolongation
what is unique about Baxdela?
covers MRSA + pseudomonas
no QT prolongation or photosensitivity
Note 
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