Pharmaceutics Exam 2

pharmaceutical powder

mixture of finely divided drugs of chemicals in dry form

True or false. Powders may be used internally or externally

True

Single-dose powders

Pre measured and packaged for indiivudal use (e.g: sachets for oral reconsituttion)

Bulk powders

Large quantities for multiple doses (e.g: topical powders or bulk laxatives)

Powders

often basis for more complex dosage forms like tablets or capsules

• play a big role in solid form formulations

Powders used in many forms

• Orally 

• Via the nose as snuffs 

• Infufflations 

• Dissolved solutions 

Insufflations

powders blown into body cavity

Powders skip the _______ step

disintegration

Micromeritics

study of powder characteristics, including particle size and size distribution, shape, angle of repose, porosity, true volume, bulk volume, apparent desnity, and bulkiness

Key Properties of Micromeritics

• Particle size (Sieve analysis & Microscopy)

• Powder desnity 

• Flow characteristic (fluidity) 

Powder density

bulk density→ Light or Heavy

Flow characteristic (fluidity)

free flowing powder versus cohesive powder

• powders are good for upscale manufacturing

Powder particle size

ranges from 1 cm to 1 micrometer 

Percentage of material retained by a series of standard _______

sieves

3 mesh exmaple

largest sizse

Larger mesh number indicates ____ pore sizes in tghe sieves

smaller

Sedimentation rate 

Determine by measuring the particle settling rate in a liquid medium via Stokes law 

Sieving

the most common way to assess particle size for powders