Pathways for Transporting Inner Mitochondrial Proteins
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What are the three pathways for inner mitochondrial membrane protein transport?
The presequence pathway, the carrier pathway, and the OXA pathway.
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What happens in the presequence pathway?
Proteins with an N-terminal presequence are imported via TOM and TIM23 complexes and inserted into the inner membrane.
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What happens in the carrier pathway?
Multi-pass carrier proteins are recognized by cytosolic chaperones, imported via TOM, guided by small TIMs, and inserted by the TIM22 complex.
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What happens in the OXA pathway?
Proteins synthesized within mitochondria or imported from the cytosol are inserted into the inner membrane through the OXA1 complex.
Note 
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