Clin med EHO simple/fill in blanks

reticulocytopenia

diminished production RBCs

reticulocytosis

accelerated loss RBCs

reticulocytes

immature precursors to RBCs

mirocytic anemia

MCV less than 80

IDA, thalassemia, anemia of chronic disease, sideroblastic anemia

normocytic anemia

MCV 80-100

kidney disease, acute hemorrhage

macrocytic anemia

MCV >100

Megaloblastic (folate and B12 deficiency) vs non-megaloblastic

serum iron

measures iron bound to transferrin

normal: 60-170

TIBC

total iron binding capacity

normal: 240-450

transferrin

iron-binding blood plasma glycoproteins that control level of free iron in biological fluids

normal: 20-50%

ferritin

iron stores

male normal: 12-300

female normal: 12-150

serum ferritin indicating IDA

less than 12

MCC IDA

chronic blood loss (GI and menstrual)

where is iron absorbed

stomach, duodenum, upper jejunum

gastrectomies will need lifelong iron supplementation

hepcidin

promotes degradation of ferroportin which restricts iron absorption in gut

plummer-vinson syndrome

IDA with dysphagia from esophageal webs

stages of IDA

depletion of iron stores without anemia

anemia with normal RBC size

anemia with microcytosis