Rho Chi Practice Questions

Drug X closes a channel that an anion uses to flow out the cell, Drug X would likely be

a) inhibit cellular activity due to depolarizing the cell

b) inhibit cellular activity due to hyperpolarizing the cell

c) increase cellular activity due to depolarizing the cell

d) increase cellular activity due to hyperpolarizing the cell

b) inhibit cellular activity due to hyperpolarizing the cell

inhibition of phosphodiesterase :

a) will increase levels of cAMP

b) will reduce formation of Diacylglycerol

c) will increase levels of IP3

d) will lead to reduced levels of calcium

a) will increase levels of cAMP

what is the effect observed when 2 active drugs are used in synergy

a) a potentiated effect

b) a larger effect when compared to an additive effect

c) the effect of one drug cancels out the effect of the other

d) none of the above

b) a larger effect when compared to an additive effect

a patient takes drug A, which produces a therapeutic effect in the patient. Drug A is metabolized by p450 3A4 and by n-acetyl transferase into active metabolite. She then begins taking Drug B and notices that the effect of Drug A is less than it had been in the past. Which of these might be occurring?

a) Drug B might be inducing the gene for N-acetyl transferase

b) the patient has developed a SNP for the gene 3A4

c) Drug B inhibits 3A4

d) Drug B might be inducing the gene for 3A4

d) Drug B might be inducing the gene for 3A4

Which line is a partial agonist

C

which drug is the safest

a) ED50 = 10 mcg, LD50= 1 mg

b) ED50= 30 ng, LD50 = 60 mcg

c) ED50= 2 mcg, LD50 = 10 mg

d) ED50 = 20 mcg, LD50 = 40 mg

c) ED50= 2 mcg, LD50 = 10 mg

SATA: which of the following is true

a) metabolic ratio = drug / metabolite

b) therapeutic index = LD50/ED50

c) metabolic ratio = metabolite/drug

d) therapeutic index = ED50/LD50

a) metabolic ratio = drug / metabolite

b) therapeutic index = LD50/ED50

increased gene transcription is a direct result of activating which type of receptor ?

a) ligand-gated ion channel

b) steroid receptor

c) tyrosine kinase receptor

d) G protein-coupled receptor

b) steroid receptor

A drug undergoing phase II metabolism may increase in molecular weight

a) true

b) false

a) true

Which G coupled protein receptor type is responsible for the formation of cAMP and the stimulation of Protein Kinase A

a) Gs

b) Gi

c) Gq

d)G12

a) Gs

Which of these targets is most selective for its target?

a) Kd at target 10 nM and Kd at other protein 800 nM

b) Kd at target 10 nM and Kd at other protein 0.1 nM

c) Kd at target 10 nM and Kd at other protein 800 uM

d) Kd at target 500 nM and Kd at other protein 800 nM

c) Kd at target 10 nM and Kd at other protein 800 uM

Which effect often has a genetic basis?

a) fetopathic effect

b) toxic effect

c) allergic effect

d) idiosyncratic effect

d) idiosyncratic effect

At basal state, a very small amount of cAMP or IP3 can be measured

a) True

b) False

a) True

Which of the following is least potent?

a) Emax 100%, ED50 100 um

b) Emax 100%, ED50 50 mM

c) Emax 60%, ED50 100 uM

d) Emax 100%, ED50 2nM

b) Emax 100%, ED50 50 mM

IP3 is a product of phosphodiesterase, and it activates protein kinase C

a) The first half of this sentence is true and the second half is also true

b) The first half of this sentence is not true but the second half is true

c) The first half of this sentence is true but the second half is not true

d) The first half and second half of the sentence is not true

d) The first half and second half of the sentence is not true

Which process is most closely linked to hyperpolarization?

a) Na+ influx

b) K+ influx

c) Na+ efflux

d) K+ efflux

d) K+ efflux

Which of the following is considered a 2nd messenger? (Select all)

a) cAMP

b) Adenylyl cyclase

c) phospholipase C

d) IP3

a) cAMP

d) IP3

Which of the following is most likely to have a delayed biological response?

a) ion channel

b) G-protein coupled receptor

c) nuclear hormone receptor

d) receptor tyrosine kinase

c) nuclear hormone receptor

If a partial agonist has an affinity of 40 nM for the active receptor, its affinity for inactive receptor could be:

a) 4 nM

b) 1 uM

c) 2 nM

d) not enough info to answer question

b) 1 uM

A G-protein coupled receptor physically comes into contact with which of the following?

a) a ligand

b) a second messenger

c) an effector protein

d) a + c

a) a ligand