smoking cessation pharmacology

which drug is involved with smoking cessation?

• nicotine

nicotine _____ terminal bronchioles

• constricts

what is the important brain “reward pathway” involved? EXAM q

• mesolimbic dopamine pathway

what is the key detector of rewarding stimulus?

VTA-NAc

nicotine stimulates the release of ____, ____, ____, ____, ____, _____, and _____

• Ach

• NE

• E

• 5-HT

• Histamine

• DA

• endorphins

varenicline moa possible exam q

• partial agonist at a4b2

• full agonist at a7 nicotinic receptor

varenicline ADR possible exam q

• unusual dreams/behaviors

bupropion moa exam q

• noncompetitive antagonist alpha nicotinic receptor

bupropion ADR

• dry mouth, nausea, stomach pain