Pedigrees, Gene Pools and Heritability- Lecture 12

pedigrees

Inheritance patterns of particular traits can be assessed/described

Autosomal dominant

Does not skip generations/Can't be a carrier

Autosomal dominant examples

Huntington's, hypocholesterolemia, achondroplasia, polydactyly

Autosomal recessive

Can skip generations (but doesn't have to)/ Can have carriers

Autosomal recessive examples

Tay Sachs, Sickle Cell Disease, Cystic Fibrosis

X-linked dominant

-All daughters of a father who has the trait will also have the trait
- NO male to male transmission
- Sons have it only if the mother has it

X-linked dominant example

Fragile X Syndrome

X-linked recessive

- Can skip generations, females can be carriers
- Males only need one copy
- If mother has it, all of sons will have it

X-linked recessive examples

Hemophilia, RG colorblind, Duchenne muscular dystrophy

gene pool

all the different alleles and relative frequency of each allele in a given population

population

A group of individuals from the same species that live in the same area and interbreed, producing fertile offspring

Heritability

how much variation in a characteristic (between individuals in a population) is associated w/differences in genetic makeup between individuals in a population