Oral Liquids-[Principles involved in Manufacturing of Liquids]

Proverbs 16:3

1. Preparation of formulation materials and equipment

2. Compounding

3. Storage and Aging

4. Filtration and Clarification

5. Filling and Packaging

General Steps In Manufacturing Solutions [5]

Preparation of formulation materials and equipment

[General Steps In Manufacturing Solutions]

Principle involved:

• GMP

• Accuracy

• Cleanliness

Preparation of formulation materials and equipment

[General Steps In Manufacturing Solutions]

Selection, weighing, and verification of raw materials (API, solvents, excipients).

Preparation of formulation materials and equipment

[General Steps In Manufacturing Solutions]

Cleaning, sanitizing, and calibration of equipment

Preparation of formulation materials and equipment

[General Steps In Manufacturing Solutions]

Use of purified water

Preparation of formulation materials and equipment

[General Steps In Manufacturing Solutions]

Ensures accuracy, safety, and prevention of contamination

Compounding

[General Steps In Manufacturing Solutions]

Principle involved:

• Solubility

• Mixing

• Compatibility

Compounding

[General Steps In Manufacturing Solutions]

Dissolving the API and Excipients in the appropriate solvent

Compounding

[General Steps In Manufacturing Solutions]

Proper order of mixing to avoid precipitation or incompatibility.

Compounding

[General Steps In Manufacturing Solutions]

Use of heat or agitation if necessary.

Storage and Aging

[General Steps In Manufacturing Solutions]

Principle involved:

• Equilibration

• Stabilization

Storage and Aging

[General Steps In Manufacturing Solutions]

Allows entrapped air to escape

Storage and Aging

[General Steps In Manufacturing Solutions]

Ensures complete dissolution and uniformity

Storage and Aging

[General Steps In Manufacturing Solutions]

Helps stabilize the solution before filtration

Plant materials

Storage and Aging are commonly used in _____ materials ?

TRUE

[General Steps In Manufacturing Solutions]

TRUE OR FALSE

• AGING improves clarity and consistency

Filtration and Clarification

[General Steps In Manufacturing Solutions]

Principle involved:

• Physical stability

• Clarity

Filtration and Clarification

[General Steps In Manufacturing Solutions]

Removal of undissolved particles, foreign matter, and turbidity

Filtration and Clarification

[General Steps In Manufacturing Solutions]

Produces a clear and aesthetically acceptable solution

Filtration and Clarification

[General Steps In Manufacturing Solutions]

Improves product quality and appearance

Filling and Packaging

[General Steps In Manufacturing Solutions]

Principle involved:

• Protection

• Dose accuracy

Filling and Packaging

[General Steps In Manufacturing Solutions]
Filling into appropriate containers (amber bottles if light-sensitive)

Filling and Packaging

[General Steps In Manufacturing Solutions]
Proper sealing and labeling

Filling and Packaging

[General Steps In Manufacturing Solutions]

Protects from contamination, light, and moisture