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Chronological development A method of organization that describes events in the order in which they occurred Lifespan development the field of study that examines patterns of growth, change, and stability in behavior that occur throughout the entire life span Nature and nurture the debate of weather you are shaped by your environment or genes Continuous development view that development is a cumulative process: gradually improving on existing skills Discontinuous development view that development takes place in unique stages, which happen at specific times or ages teratogens agents, such as chemicals and viruses, that can reach the embryo or fetus during prenatal development and cause harm Fine motor coordination - involves small muscle groups - usually includes finger dexterity and/or skilled manipulation of objects with the hands Gross motor coordination -- Ability to coordinate large muscle movements as in running, walking, skipping, and throwing. Maturation biological growth processes that enable orderly changes in behavior, relatively uninfluenced by experience Reflexes specific patterns of motor response that are triggered by specific patterns of sensory stimulation Rooting reflex a baby's tendency, when touched on the cheek, to turn toward the touch, open the mouth, and search for the nipple Visual cliff a laboratory device for testing depth perception in infants and young animals Critical periods Periods in the developmental sequence during which an organism must experience certain kinds of social or sensory experiences in order for normal development to take place Sensitive periods time periods when specific skills develop most easily Imprinting the process by which certain animals form strong attachments during an early-life critical period Growth spurt The relatively sudden and rapid physical growth that occurs during puberty. Each body part increases in size on a schedule: Weight usually precedes height, and growth of the limbs precedes growth of the torso. Puberty the period of sexual maturation, during which a person becomes capable of reproducing Primary sex characteristics the body structures (ovaries, testes, and external genitalia) that make sexual reproduction possible Secondary sex characteristics nonreproductive sexual characteristics, such as female breasts and hips, male voice quality, and body hair Menarche the first menstrual period Spermarche first ejaculation Menopause the time of natural cessation of menstruation; also refers to the biological changes a woman experiences as her ability to reproduce declines Schemas Concepts or mental frameworks that organize and interpret information. assimilation interpreting our new experiences in terms of our existing schemas accommodation adapting our current understandings (schemas) to incorporate new information sensorimotor stage in Piaget's theory, the stage (from birth to about 2 years of age) during which infants know the world mostly in terms of their sensory impressions and motor activities object permanence the awareness that things continue to exist even when not perceived Preoperational stage in Piaget's theory, the stage (from about 2 to 6 or 7 years of age) during which a child learns to use language but does not yet comprehend the mental operations of concrete logic Mental symbols represent objects in the real world Pretend play make-believe activities in which children create new symbolic relations, acting as if they were in a situation different from their actual one Conservation the principle (which Piaget believed to be a part of concrete operational reasoning) that properties such as mass, volume, and number remain the same despite changes in the forms of objects Reversibility the capacity to think through a series of steps and then mentally reverse direction, returning to the starting point Animism Belief that objects, such as plants and stones, or natural events, like thunderstorms and earthquakes, have a discrete spirit and conscious life. Egocentrism in Piaget's theory, the preoperational child's difficulty taking another's point of view Theory of mind an awareness that other people's behavior may be influenced by beliefs, desires, and emotions that differ from one's own Concrete operational stage in Piaget's theory, the stage of cognitive development (from about 6 or 7 to 11 years of age) during which children gain the mental operations that enable them to think logically about concrete events Systematic thinking approaches problems in a rational, step-by-step, and analytical fashion Formal operational stage in Piaget's theory, the stage of cognitive development (normally beginning about age 12) during which people begin to think logically about abstract concepts Abstract thinking capacity to understand hypothetical concepts Scaffolding Adjusting the support offered during a teaching session to fit the child's current level of performance Zone of proximal development (ZPD) Vygotsky's concept of the difference between what a child can do alone and what that child can do with the help of a teacher Crystallized intelligence our accumulated knowledge and verbal skills; tends to increase with age Fluid intelligence our ability to reason speedily and abstractly; tends to decrease during late adulthood Dementia a slowly progressive decline in mental abilities, including memory, thinking, and judgment, that is often accompanied by personality changes Phonemes in language, the smallest distinctive sound unit Morphemes The smallest units of meaning in a language. Semantics the set of rules by which we derive meaning from morphemes, words, and sentences in a given language; also, the study of meaning Grammar in a language, a system of rules that enables us to communicate with and understand others Syntax Sentence structure Cooing early vowel-like sounds that babies produce Babbling stage of language development at about 4 months when an infant spontaneously utters nonsense sounds One-word stage the stage in speech development, from about age 1 to 2, during which a child speaks mostly in single words Telegraphic speech early speech stage in which a child speaks like a telegram—"go car"—using mostly nouns and verbs. Overgeneralization of language rules Applying a regular grammatical rule in an irregular situation. Example: "I runned", "he hitted", "you buyed" Ecological systems theory views the person as developing within a complex system of relationships affected by multiple levels of the surrounding environment Microsystem the people and objects in an individual's immediate environment Mesosystem connections between microsystems Exosystem social settings that a person may not experience firsthand but that still influence development Macrosystem consists of cultural values, laws, customs, and resources Chronosystem historical changes that influence the other systems Authoritarian parenting style of parenting in which parent is rigid and overly strict, showing little warmth to the child Authoritative parenting parenting style characterized by emotional warmth, high standards for behavior, explanation and consistent enforcement of rules, and inclusion of children in decision making Permissive parenting A parenting style characterized by the placement of few limits on the child's behavior. Attachment styles The expectations people develop about relationships with others, based on the relationship they had with their primary caregiver when they were infants Secure attachment a relationship in which an infant obtains both comfort and confidence from the presence of his or her caregiver Insecure attachment demonstrated by infants who display either a clinging, anxious attachment or an avoidant attachment that resists closeness Avoidant attachment attachments marked by discomfort over, or resistance to, being close to others Anxious attachment attachments marked by anxiety or ambivalence. an insecure attachment style disorganized attachment characterized by the child's odd behavior when faced with the parent; type of attachment seen most often with kids that are abused Temperment a person's characteristic emotional reactivity and intensity Separation anxiety the distress displayed by infants when a customary care provider departs Parallel play activity in which children play side by side without interacting Pretend play make-believe activities in which children create new symbolic relations, acting as if they were in a situation different from their actual one Imaginary Audience adolescents' belief that they are the focus of everyone else's attention and concern Personal fable type of thought common to adolescents in which young people believe themselves to be unique and protected from harm Social clock the culturally preferred timing of social events such as marriage, parenthood, and retirement Emerging adulthood a period from about age 18 to the mid-twenties, when many in Western cultures are no longer adolescents but have not yet achieved full independence as adults Stage theory of psychosocial development Erikson's theory; 8 stages with distinct conflicts between two opposing states that shape personality Trust vs. mistrust Refers to a stage of development from birth to approximately 18 months of age, during which infants gain trust of their parents or caregivers if their world is planned, organized, and routine. Autonomy vs. Shame and Doubt Erikson's stage in which a toddler learns to exercise will and to do things independently; failure to do so causes shame and doubt Initiative v. guilt 3rd stage in Erikson's model; preschoolers must learn to start and direct creative tasks, or they may feel guilty about asserting themselves Industry v. Inferiority 4th stage in Erikson's model; children must master the skills valued by their society or feel inferior Identity v. role confusion 5th stage in Erikson's model; adolescents must develop a sense of identity or suffer lack of direction Intimacy v. isolation 6th stage in Erikson's model; young adults must form close, satisfying relationships or suffer loneliness Generativity vs. Stagnation Erikson's 7th stage of social development in which middle-aged people begin to devote themselves more to fulfilling one's potential and doing public service Integrity v. despair 8th stage in Erikson's model; when reflecting at the end of life, an older adult must feel a sense of satisfaction or experience despair (feelings of having wasted one's life) Adverse Childhood Experiences (ACEs) Stressful or traumatic experiences, including abuse, neglect, and a range of household dysfunction, such as witnessing domestic violence or growing up with substance abuse, mental disorders, parental discord, or crime in the home. Achievement (adolescent development) Stage of adolescent identity development that occurs when identity commitments are made after a period of exploration. Diffusion (adolescent development) Stage of adolescent identity development where no commitments are made to identity Foreclosure (adolescent development) Stage of adolescent identity development where commitments are made to identity without first an exploration Moratorium (adolescent development) Stage of adolescent identity development where they are actively engaged in identity exploration racial and ethnic identity the sense of membership in a racial or ethnic group and the feelings that are associated with that membership Sexual orientation an enduring sexual attraction toward members of either one's own sex (homosexual orientation) or the other sex (heterosexual orientation) Religious identity a sense of belonging to a religious group Occupational identity Occupations that we engage in define who we are Familial identity the sense of self as always connected to family and others Possible selves images of what we dream of or dread becoming in the future Behavioral perspective An approach to the study of psychology that focuses on the role of learning in explaining observable behavior. Classical conditioning a type of learning in which one learns to link two or more stimuli and anticipate events Association any connection between thoughts, feelings, or experiences that leads one to recall another Acquisition In classical conditioning, the initial stage, when one links a neutral stimulus and an unconditioned stimulus so that the neutral stimulus begins triggering the conditioned response. In operant conditioning, the strengthening of a reinforced response. Associative learning learning that certain events occur together. The events may be two stimuli (as in classical conditioning) or a response and its consequences (as in operant conditioning). Unconditioned stimulus (US) in classical conditioning, a stimulus that naturally and automatically triggers a response. Unconditioned response (UR) In classical conditioning, the unlearned, naturally occurring response to the unconditioned stimulus (US), such as salivation when food is in the mouth. Conditioned response (CR) in classical conditioning, the learned response to a previously neutral (but now conditioned) stimulus (CS) Conditioned Stimulus (CS) in classical conditioning, an originally irrelevant stimulus that, after association with an unconditioned stimulus, comes to trigger a conditioned response Extinction the diminishing of a conditioned response; occurs in classical conditioning when an unconditioned stimulus (US) does not follow a conditioned stimulus (CS); occurs in operant conditioning when a response is no longer reinforced. Spontaneous recovery the reappearance, after a pause, of an extinguished conditioned response Stimulus discrimination a differentiation between two similar stimuli when only one of them is consistently associated with the unconditioned stimulus stimulus generalization learning that occurs when stimuli that are similar but not identical to the conditioned stimulus produce the conditioned response Higher-order conditioning a procedure in which the conditioned stimulus in one conditioning experience is paired with a new neutral stimulus, creating a second (often weaker) conditioned stimulus. For example, an animal that has learned that a tone predicts food might then learn that a light predicts the tone and begin responding to the light alone. (Also called second-order conditioning.) Counterconditioning a behavior therapy procedure that uses classical conditioning to evoke new responses to stimuli that are triggering unwanted behaviors; includes exposure therapies and aversive conditioning Taste aversion a type of classical conditioning in which a previously desirable or neutral food comes to be perceived as repugnant because it is associated with negative stimulation One-trial conditioning when one pairing of CS and a US produces considerable learning Habituation decreasing responsiveness with repeated stimulation. As infants gain familiarity with repeated exposure to a visual stimulus, their interest wanes and they look away sooner. Operant conditioning a type of learning in which behavior is strengthened if followed by a reinforcer or diminished if followed by a punisher Reinforcement in operant conditioning, any event that strengthens the behavior it follows Punishment an event that decreases the behavior that it follows Law of effect Thorndike's principle that behaviors followed by favorable consequences become more likely, and that behaviors followed by unfavorable consequences become less likely Positive reinforcement Increasing behaviors by presenting positive stimuli, such as food.Any stimulus that, when presented after a response, strengthens the response. Negative reinforcement Increasing behaviors by stopping or reducing negative stimuli, such as shock. Any stimulus that, when removed after a response, strengthens the response. (Note: negative reinforcement is not punishment.) Primary reinforcers Events that are inherently reinforcing because they satisfy biological needs Secondary reinforcers learned reinforcers, such as money, that develop their reinforcing properties because of their association with primary reinforcers Shaping an operant conditioning procedure in which reinforcers guide behavior toward closer and closer approximations of the desired behavior Instinctive drift the tendency of learned behavior to gradually revert to biologically predisposed patterns Superstitious behavior a behavior repeated because it seems to produce reinforcement, even though it is actually unnecessary Learned helplessness the hopelessness and passive resignation an animal or human learns when unable to avoid repeated aversive events Reinforcement schedule a pattern that defines how often a desired response will be reinforced fixed interval reinforcement A form of partial reinforcement where rewards are provided after a specific time interval has passed after a response Fixed ratio reinforcement reinforces a response only after a specified number of responses Variable ratio reinforcement A form of partial reinforcement where rewards are provided after an unpredictable number of responses Scalloped graph The graphed pattern of a fixed interval reinforcement schedule Social learning theory the theory that we learn social behavior by observing and imitating and by being rewarded or punished Vicarious conditioning classical conditioning of a reflex response or emotion by watching the reaction of another person Modeling learning by imitating others; copying behavior Insight learning The process of learning how to solve a problem or do something new by applying what is already known Latent learning learning that occurs but is not apparent until there is an incentive to demonstrate it Cognitive maps An internal representation of the spatial relationships between objects in an animal's surroundings.
Updated 13h ago
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Chronological development A method of organization that describes events in the order in which they occurred Lifespan development the field of study that examines patterns of growth, change, and stability in behavior that occur throughout the entire life span Nature and nurture the debate of weather you are shaped by your environment or genes Continuous development view that development is a cumulative process: gradually improving on existing skills Discontinuous development view that development takes place in unique stages, which happen at specific times or ages teratogens agents, such as chemicals and viruses, that can reach the embryo or fetus during prenatal development and cause harm Fine motor coordination - involves small muscle groups - usually includes finger dexterity and/or skilled manipulation of objects with the hands Gross motor coordination -- Ability to coordinate large muscle movements as in running, walking, skipping, and throwing. Maturation biological growth processes that enable orderly changes in behavior, relatively uninfluenced by experience Reflexes specific patterns of motor response that are triggered by specific patterns of sensory stimulation Rooting reflex a baby's tendency, when touched on the cheek, to turn toward the touch, open the mouth, and search for the nipple Visual cliff a laboratory device for testing depth perception in infants and young animals Critical periods Periods in the developmental sequence during which an organism must experience certain kinds of social or sensory experiences in order for normal development to take place Sensitive periods time periods when specific skills develop most easily Imprinting the process by which certain animals form strong attachments during an early-life critical period Growth spurt The relatively sudden and rapid physical growth that occurs during puberty. Each body part increases in size on a schedule: Weight usually precedes height, and growth of the limbs precedes growth of the torso. Puberty the period of sexual maturation, during which a person becomes capable of reproducing Primary sex characteristics the body structures (ovaries, testes, and external genitalia) that make sexual reproduction possible Secondary sex characteristics nonreproductive sexual characteristics, such as female breasts and hips, male voice quality, and body hair Menarche the first menstrual period Spermarche first ejaculation Menopause the time of natural cessation of menstruation; also refers to the biological changes a woman experiences as her ability to reproduce declines Schemas Concepts or mental frameworks that organize and interpret information. assimilation interpreting our new experiences in terms of our existing schemas accommodation adapting our current understandings (schemas) to incorporate new information sensorimotor stage in Piaget's theory, the stage (from birth to about 2 years of age) during which infants know the world mostly in terms of their sensory impressions and motor activities object permanence the awareness that things continue to exist even when not perceived Preoperational stage in Piaget's theory, the stage (from about 2 to 6 or 7 years of age) during which a child learns to use language but does not yet comprehend the mental operations of concrete logic Mental symbols represent objects in the real world Pretend play make-believe activities in which children create new symbolic relations, acting as if they were in a situation different from their actual one Conservation the principle (which Piaget believed to be a part of concrete operational reasoning) that properties such as mass, volume, and number remain the same despite changes in the forms of objects Reversibility the capacity to think through a series of steps and then mentally reverse direction, returning to the starting point Animism Belief that objects, such as plants and stones, or natural events, like thunderstorms and earthquakes, have a discrete spirit and conscious life. Egocentrism in Piaget's theory, the preoperational child's difficulty taking another's point of view Theory of mind an awareness that other people's behavior may be influenced by beliefs, desires, and emotions that differ from one's own Concrete operational stage in Piaget's theory, the stage of cognitive development (from about 6 or 7 to 11 years of age) during which children gain the mental operations that enable them to think logically about concrete events Systematic thinking approaches problems in a rational, step-by-step, and analytical fashion Formal operational stage in Piaget's theory, the stage of cognitive development (normally beginning about age 12) during which people begin to think logically about abstract concepts Abstract thinking capacity to understand hypothetical concepts Scaffolding Adjusting the support offered during a teaching session to fit the child's current level of performance Zone of proximal development (ZPD) Vygotsky's concept of the difference between what a child can do alone and what that child can do with the help of a teacher Crystallized intelligence our accumulated knowledge and verbal skills; tends to increase with age Fluid intelligence our ability to reason speedily and abstractly; tends to decrease during late adulthood Dementia a slowly progressive decline in mental abilities, including memory, thinking, and judgment, that is often accompanied by personality changes Phonemes in language, the smallest distinctive sound unit Morphemes The smallest units of meaning in a language. Semantics the set of rules by which we derive meaning from morphemes, words, and sentences in a given language; also, the study of meaning Grammar in a language, a system of rules that enables us to communicate with and understand others Syntax Sentence structure Cooing early vowel-like sounds that babies produce Babbling stage of language development at about 4 months when an infant spontaneously utters nonsense sounds One-word stage the stage in speech development, from about age 1 to 2, during which a child speaks mostly in single words Telegraphic speech early speech stage in which a child speaks like a telegram—"go car"—using mostly nouns and verbs. Overgeneralization of language rules Applying a regular grammatical rule in an irregular situation. Example: "I runned", "he hitted", "you buyed" Ecological systems theory views the person as developing within a complex system of relationships affected by multiple levels of the surrounding environment Microsystem the people and objects in an individual's immediate environment Mesosystem connections between microsystems Exosystem social settings that a person may not experience firsthand but that still influence development Macrosystem consists of cultural values, laws, customs, and resources Chronosystem historical changes that influence the other systems Authoritarian parenting style of parenting in which parent is rigid and overly strict, showing little warmth to the child Authoritative parenting parenting style characterized by emotional warmth, high standards for behavior, explanation and consistent enforcement of rules, and inclusion of children in decision making Permissive parenting A parenting style characterized by the placement of few limits on the child's behavior. Attachment styles The expectations people develop about relationships with others, based on the relationship they had with their primary caregiver when they were infants Secure attachment a relationship in which an infant obtains both comfort and confidence from the presence of his or her caregiver Insecure attachment demonstrated by infants who display either a clinging, anxious attachment or an avoidant attachment that resists closeness Avoidant attachment attachments marked by discomfort over, or resistance to, being close to others Anxious attachment attachments marked by anxiety or ambivalence. an insecure attachment style disorganized attachment characterized by the child's odd behavior when faced with the parent; type of attachment seen most often with kids that are abused Temperment a person's characteristic emotional reactivity and intensity Separation anxiety the distress displayed by infants when a customary care provider departs Parallel play activity in which children play side by side without interacting Pretend play make-believe activities in which children create new symbolic relations, acting as if they were in a situation different from their actual one Imaginary Audience adolescents' belief that they are the focus of everyone else's attention and concern Personal fable type of thought common to adolescents in which young people believe themselves to be unique and protected from harm Social clock the culturally preferred timing of social events such as marriage, parenthood, and retirement Emerging adulthood a period from about age 18 to the mid-twenties, when many in Western cultures are no longer adolescents but have not yet achieved full independence as adults Stage theory of psychosocial development Erikson's theory; 8 stages with distinct conflicts between two opposing states that shape personality Trust vs. mistrust Refers to a stage of development from birth to approximately 18 months of age, during which infants gain trust of their parents or caregivers if their world is planned, organized, and routine. Autonomy vs. Shame and Doubt Erikson's stage in which a toddler learns to exercise will and to do things independently; failure to do so causes shame and doubt Initiative v. guilt 3rd stage in Erikson's model; preschoolers must learn to start and direct creative tasks, or they may feel guilty about asserting themselves Industry v. Inferiority 4th stage in Erikson's model; children must master the skills valued by their society or feel inferior Identity v. role confusion 5th stage in Erikson's model; adolescents must develop a sense of identity or suffer lack of direction Intimacy v. isolation 6th stage in Erikson's model; young adults must form close, satisfying relationships or suffer loneliness Generativity vs. Stagnation Erikson's 7th stage of social development in which middle-aged people begin to devote themselves more to fulfilling one's potential and doing public service Integrity v. despair 8th stage in Erikson's model; when reflecting at the end of life, an older adult must feel a sense of satisfaction or experience despair (feelings of having wasted one's life) Adverse Childhood Experiences (ACEs) Stressful or traumatic experiences, including abuse, neglect, and a range of household dysfunction, such as witnessing domestic violence or growing up with substance abuse, mental disorders, parental discord, or crime in the home. Achievement (adolescent development) Stage of adolescent identity development that occurs when identity commitments are made after a period of exploration. Diffusion (adolescent development) Stage of adolescent identity development where no commitments are made to identity Foreclosure (adolescent development) Stage of adolescent identity development where commitments are made to identity without first an exploration Moratorium (adolescent development) Stage of adolescent identity development where they are actively engaged in identity exploration racial and ethnic identity the sense of membership in a racial or ethnic group and the feelings that are associated with that membership Sexual orientation an enduring sexual attraction toward members of either one's own sex (homosexual orientation) or the other sex (heterosexual orientation) Religious identity a sense of belonging to a religious group Occupational identity Occupations that we engage in define who we are Familial identity the sense of self as always connected to family and others Possible selves images of what we dream of or dread becoming in the future Behavioral perspective An approach to the study of psychology that focuses on the role of learning in explaining observable behavior. Classical conditioning a type of learning in which one learns to link two or more stimuli and anticipate events Association any connection between thoughts, feelings, or experiences that leads one to recall another Acquisition In classical conditioning, the initial stage, when one links a neutral stimulus and an unconditioned stimulus so that the neutral stimulus begins triggering the conditioned response. In operant conditioning, the strengthening of a reinforced response. Associative learning learning that certain events occur together. The events may be two stimuli (as in classical conditioning) or a response and its consequences (as in operant conditioning). Unconditioned stimulus (US) in classical conditioning, a stimulus that naturally and automatically triggers a response. Unconditioned response (UR) In classical conditioning, the unlearned, naturally occurring response to the unconditioned stimulus (US), such as salivation when food is in the mouth. Conditioned response (CR) in classical conditioning, the learned response to a previously neutral (but now conditioned) stimulus (CS) Conditioned Stimulus (CS) in classical conditioning, an originally irrelevant stimulus that, after association with an unconditioned stimulus, comes to trigger a conditioned response Extinction the diminishing of a conditioned response; occurs in classical conditioning when an unconditioned stimulus (US) does not follow a conditioned stimulus (CS); occurs in operant conditioning when a response is no longer reinforced. Spontaneous recovery the reappearance, after a pause, of an extinguished conditioned response Stimulus discrimination a differentiation between two similar stimuli when only one of them is consistently associated with the unconditioned stimulus stimulus generalization learning that occurs when stimuli that are similar but not identical to the conditioned stimulus produce the conditioned response Higher-order conditioning a procedure in which the conditioned stimulus in one conditioning experience is paired with a new neutral stimulus, creating a second (often weaker) conditioned stimulus. For example, an animal that has learned that a tone predicts food might then learn that a light predicts the tone and begin responding to the light alone. (Also called second-order conditioning.) Counterconditioning a behavior therapy procedure that uses classical conditioning to evoke new responses to stimuli that are triggering unwanted behaviors; includes exposure therapies and aversive conditioning Taste aversion a type of classical conditioning in which a previously desirable or neutral food comes to be perceived as repugnant because it is associated with negative stimulation One-trial conditioning when one pairing of CS and a US produces considerable learning Habituation decreasing responsiveness with repeated stimulation. As infants gain familiarity with repeated exposure to a visual stimulus, their interest wanes and they look away sooner. Operant conditioning a type of learning in which behavior is strengthened if followed by a reinforcer or diminished if followed by a punisher Reinforcement in operant conditioning, any event that strengthens the behavior it follows Punishment an event that decreases the behavior that it follows Law of effect Thorndike's principle that behaviors followed by favorable consequences become more likely, and that behaviors followed by unfavorable consequences become less likely Positive reinforcement Increasing behaviors by presenting positive stimuli, such as food.Any stimulus that, when presented after a response, strengthens the response. Negative reinforcement Increasing behaviors by stopping or reducing negative stimuli, such as shock. Any stimulus that, when removed after a response, strengthens the response. (Note: negative reinforcement is not punishment.) Primary reinforcers Events that are inherently reinforcing because they satisfy biological needs Secondary reinforcers learned reinforcers, such as money, that develop their reinforcing properties because of their association with primary reinforcers Shaping an operant conditioning procedure in which reinforcers guide behavior toward closer and closer approximations of the desired behavior Instinctive drift the tendency of learned behavior to gradually revert to biologically predisposed patterns Superstitious behavior a behavior repeated because it seems to produce reinforcement, even though it is actually unnecessary Learned helplessness the hopelessness and passive resignation an animal or human learns when unable to avoid repeated aversive events Reinforcement schedule a pattern that defines how often a desired response will be reinforced fixed interval reinforcement A form of partial reinforcement where rewards are provided after a specific time interval has passed after a response Fixed ratio reinforcement reinforces a response only after a specified number of responses Variable ratio reinforcement A form of partial reinforcement where rewards are provided after an unpredictable number of responses Scalloped graph The graphed pattern of a fixed interval reinforcement schedule Social learning theory the theory that we learn social behavior by observing and imitating and by being rewarded or punished Vicarious conditioning classical conditioning of a reflex response or emotion by watching the reaction of another person Modeling learning by imitating others; copying behavior Insight learning The process of learning how to solve a problem or do something new by applying what is already known Latent learning learning that occurs but is not apparent until there is an incentive to demonstrate it Cognitive maps An internal representation of the spatial relationships between objects in an animal's surroundings.
Updated 13h ago
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biology 2.1Unit 2.1: Mitosis and Meiosis Introduction By the end of this section, you should be able to: Define a chromosome. Define DNA as the genetic material. Define genes. Describe the structure of chromosomes. Describe the components of DNA. Define mitosis and describe its stages. Define meiosis and describe its stages. Relate the events of meiosis to the formation of sex cells. Compare mitosis and meiosis. Chromosomes, Genes, and DNA Almost all the cells of your body—except for mature red blood cells—contain a nucleus, which acts as the control center of the cell. The nucleus holds all the information needed to make a new cell and, ultimately, a new individual. Inside the nucleus are chromosomes, thread-like structures that store genetic information passed from parents to offspring. Chromosomes are made up of DNA (deoxyribonucleic acid), a molecule that carries the instructions needed to make all the proteins in your body. Many of these proteins are enzymes, which control the production of other chemicals and affect everything about how your body functions. Each species has a specific number of chromosomes: Humans have 46 chromosomes (23 pairs). Tomatoes have 24 chromosomes (12 pairs). Elephants have 56 chromosomes (28 pairs). Half of your chromosomes come from your mother, and the other half from your father. These chromosomes are arranged in homologous pairs, meaning they contain matching sets of genes. A karyotype is a special photograph that arranges chromosomes into their pairs. In humans, 22 pairs of chromosomes are called autosomes, which control most body functions. The 23rd pair is the sex chromosomes, which determine whether you are male or female: Females have two X chromosomes (XX). Males have one X and one Y chromosome (XY). DNA Structure DNA is a long, twisted molecule shaped like a double helix (a spiraled ladder). Each strand of DNA is made up of smaller molecules called nucleotides, which consist of: A phosphate group A sugar (deoxyribose) A nitrogen base The four nitrogen bases in DNA are: Adenine (A) → Always pairs with Thymine (T) Cytosine (C) → Always pairs with Guanine (G) Genes are small segments of DNA that carry instructions for making proteins. The sequence of these bases acts like a biological code, directing the cell to create specific proteins. In 1953, James Watson and Francis Crick, using data from Rosalind Franklin’s X-ray photographs, discovered the double-helix structure of DNA. Their discovery led to a huge increase in genetic research, including the Human Genome Project, which mapped all human genes. Mitosis (Cell Division for Growth and Repair) All body cells (somatic cells) divide using mitosis, a type of cell division that creates two identical daughter cells. Mitosis is essential for: Growth (producing new cells). Tissue repair (replacing damaged or old cells). Asexual reproduction (producing offspring with identical DNA). Stages of Mitosis Interphase The cell prepares for division by copying its DNA. Chromosomes are not visible under a microscope. Prophase Chromosomes condense and become visible. The nuclear membrane breaks down. Metaphase Chromosomes line up in the center of the cell. Spindle fibers attach to each chromosome. Anaphase The spindle fibers pull the sister chromatids apart to opposite ends of the cell. Telophase A new nuclear membrane forms around each set of chromosomes. The cell is almost ready to split. Cytokinesis The cytoplasm divides, forming two identical daughter cells. Mitosis is constantly occurring in areas like your skin and bone marrow, where new cells are needed regularly. Meiosis (Cell Division for Reproduction) Unlike mitosis, meiosis occurs only in the reproductive organs (testes in males, ovaries in females) and produces gametes (sperm and egg cells). Gametes have half the number of chromosomes (haploid, n=23) so that when fertilization occurs, the new cell has the correct chromosome number (diploid, 2n=46). Stages of Meiosis Meiosis consists of two rounds of cell division, resulting in four non-identical cells. Meiosis I: Prophase I – Chromosomes pair up and exchange genetic material (crossing over). Metaphase I – Chromosome pairs line up in the center of the cell. Anaphase I – Chromosome pairs separate and move to opposite ends of the cell. Telophase I & Cytokinesis – The cell splits into two haploid daughter cells. Meiosis II (similar to mitosis): 5. Prophase II – Chromosomes condense again. 6. Metaphase II – Chromosomes line up in the center. 7. Anaphase II – Sister chromatids separate and move to opposite sides. 8. Telophase II & Cytokinesis – Four unique haploid gametes are formed. Each gamete is genetically different due to crossing over and random chromosome distribution. Mitosis vs. Meiosis: Key Differences Importance of Mitosis and Meiosis Mitosis ensures that cells grow, repair damage, and replace old cells. Meiosis allows genetic diversity, which is essential for evolution and survival. Summary Chromosomes carry genetic information in the form of DNA. Genes are sections of DNA that code for proteins. Mitosis produces two identical daughter cells for growth and repair. Meiosis creates four non-identical sex cells for reproduction. Mitosis ensures genetic stability, while meiosis introduces genetic diversity
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Chapter 6: Adolescence Growth in Adolescence Puberty is a period of rapid growth and sexual maturation. These changes begin sometime l between eight and fourteen. Girls begin puberty at around ten years of age and boys begin approximately two years later. Pubertal changes take around three to four years to complete. Adolescents experience an overall physical growth spurt. The growth proceeds from the extremities toward the torso. This is referred to as distalproximal development. First the hands grow, then the arms, hand finally the torso. The overall physical growth spurt results in 10-11 inches of added height and 50 to 75 pounds of increased weight. The head begins to grow sometime after the feet have gone through their period of growth. Growth of the head is preceded by growth of the ears, nose, and lips. The difference in these patterns of growth result in adolescents appearing awkward and out-of-proportion. As the torso grows, so do the internal organs. The heart and lungs experience dramatic growth during this period. During childhood, boys and girls are quite similar in height and weight. However, gender differences become apparent during adolescence. From approximately age ten to fourteen, the average girl is taller, but not heavier, than the average boy. After that, the average boy becomes 223 both taller and heavier, although individual differences are certainly noted. As adolescents physically mature, weight differences are more noteworthy than height differences. At eighteen years of age, those that are heaviest weigh almost twice as much as the lightest, but the tallest teens are only about 10% taller than the shortest (Seifert, 2012). Both height and weight can certainly be sensitive issues for some teenagers. Most modern societies, and the teenagers in them, tend to favor relatively short women and tall men, as well as a somewhat thin body build, especially for girls and women. Yet, neither socially preferred height nor thinness is the destiny for many individuals. Being overweight, in particular, has become a common, serious problem in modern society due to the prevalence of diets high in fat and lifestyles low in activity (Tartamella et al., 2004). The educational system has, unfortunately, contributed to the problem as well by gradually restricting the number of physical education courses and classes in the past two decades. Average height and weight are also related somewhat to racial and ethnic background. In general, children of Asian background tend to be slightly shorter than children of European and North American background. The latter in turn tend to be shorter than children from African societies (Eveleth & Tanner, 1990). Body shape differs slightly as well, though the differences are not always visible until after puberty. Asian background youth tend to have arms and legs that are a bit short relative to their torsos, and African background youth tend to have relatively long arms and legs. The differences are only averages, as there are large individual differences as well. Sexual Development Typically, the growth spurt is followed by the development of sexual maturity. Sexual changes are divided into two categories: Primary sexual characteristics and secondary sexual characteristics. Primary sexual characteristics are changes in the reproductive organs. For males, this includes growth of the testes, penis, scrotum, and spermarche or first ejaculation of semen. This occurs between 11 and 15 years of age. For females, primary characteristics include growth of the uterus and menarche or the first menstrual period. The female gametes, which are stored in the ovaries, are present at birth, but are immature. Each ovary contains about 400,000 gametes, but only 500 will become mature eggs (Crooks & Baur, 2007). Beginning at puberty, one ovum ripens and is released about every 28 days during the menstrual cycle. Stress and higher percentage of body fat can bring menstruation at younger ages. Male Anatomy: Males have both internal and external genitalia that are responsible for procreation and sexual intercourse. Males produce their sperm on a cycle, and unlike the female's ovulation cycle, the male sperm production cycle is constantly producing millions of sperm daily. The main male sex organs are the penis and the testicles, the latter of which produce semen and sperm. The semen and sperm, as a result of sexual intercourse, can fertilize an ovum in the female's body; the fertilized ovum (zygote) develops into a fetus which is later born as a child. Female Anatomy: Female external genitalia is collectively known as the vulva, which includes the mons veneris, labia majora, labia minora, clitoris, vaginal opening, and urethral opening. Female internal reproductive organs consist of the vagina, uterus, fallopian tubes, and ovaries. The uterus hosts the developing fetus, produces vaginal and uterine secretions, and passes the male's sperm through to the fallopian tubes while the ovaries release the eggs. A female is born with all her eggs already produced. The vagina is attached to the uterus through the cervix, while the uterus is attached to the ovaries via the fallopian tubes. Females have a monthly reproductive cycle; at certain intervals the ovaries release an egg, which passes through the fallopian tube into the uterus. If, in this transit, it meets with sperm, the sperm might penetrate and merge with the egg, fertilizing it. If not fertilized, the egg is flushed out of the system through menstruation. Secondary sexual characteristics are visible physical changes not directly linked to reproduction but signal sexual maturity. For males this includes broader shoulders and a lower voice as the larynx grows. Hair becomes coarser and darker, and hair growth occurs in the pubic area, under the arms and on the face. For females, breast development occurs around age 10, although full development takes several years. Hips broaden, and pubic and underarm hair develops and also becomes darker and coarser. Acne: An unpleasant consequence of the hormonal changes in puberty is acne, defined as pimples on the skin due to overactive sebaceous (oil-producing) glands (Dolgin, 2011). These glands develop at a greater speed than the skin ducts that discharges the oil. Consequently, the ducts can become blocked with dead skin and acne will develop. According to the University of California at Los Angeles Medical Center (2000), approximately 85% of adolescents develop acne, and boys develop acne more than girls because of greater levels of testosterone in their systems (Dolgin, 2011). Experiencing acne can lead the adolescent to withdraw socially, especially if they are self-conscious about their skin or teased (Goodman, 2006). Effects of Pubertal Age: The age of puberty is getting younger for children throughout the world. According to Euling et al. (2008) data are sufficient to suggest a trend toward an earlier breast development onset and menarche in girls. A century ago the average age of a girl’s first period in the United States and Europe was 16, while today it is around 13. Because there is no clear marker of puberty for boys, it is harder to determine if boys are maturing earlier too. In addition to better nutrition, less positive reasons associated with early puberty for girls include increased stress, obesity, and endocrine disrupting chemicals. Cultural differences are noted with Asian-American girls, on average, developing last, while African American girls enter puberty the earliest. Hispanic girls start puberty the second earliest, while European-American girls rank third in their age of starting puberty. Although African American girls are typically the first to develop, they are less likely to experience negative consequences of early puberty when compared to European-American girls (Weir, 2016). Research has demonstrated mental health problems linked to children who begin puberty earlier than their peers. For girls, early puberty is associated with depression, substance use, eating disorders, disruptive behavior disorders, and early sexual behavior (Graber, 2013). Early maturing girls demonstrate more anxiety and less confidence in their relationships with family and friends, and they compare themselves more negatively to their peers (Weir, 2016). Problems with early puberty seem to be due to the mismatch between the child’s appearance and the way she acts and thinks. Adults especially may assume the child is more capable than she actually is, and parents might grant more freedom than the child’s age would indicate. For girls, the emphasis on physical attractiveness and sexuality is emphasized at puberty and they may lack effective coping strategies to deal with the attention they may receive. 226 Figure 6.4 Source Additionally, mental health problems are more likely to occur when the child is among the first in his or her peer group to develop. Because the preadolescent time is one of not wanting to appear different, early developing children stand out among their peer group and gravitate toward those who are older. For girls, this results in them interacting with older peers who engage in risky behaviors such as substance use and early sexual behavior (Weir, 2016). Boys also see changes in their emotional functioning at puberty. According to Mendle, Harden, Brooks-Gunn, and Graber (2010), while most boys experienced a decrease in depressive symptoms during puberty, boys who began puberty earlier and exhibited a rapid tempo, or a fast rate of change, actually increased in depressive symptoms. The effects of pubertal tempo were stronger than those of pubertal timing, suggesting that rapid pubertal change in boys may be a more important risk factor than the timing of development. In a further study to better analyze the reasons for this change, Mendle et al. (2012) found that both early maturing boys and rapidly maturing boys displayed decrements in the quality of their peer relationships as they moved into early adolescence, whereas boys with more typical timing and tempo development actually experienced improvements in peer relationships. The researchers concluded that the transition in peer relationships may be especially challenging for boys whose pubertal maturation differs significantly from those of others their age. Consequences for boys attaining early puberty were increased odds of cigarette, alcohol, or another drug use (Dudovitz, et al., 2015). Gender Role Intensification: At about the same time that puberty accentuates gender, role differences also accentuate for at least some teenagers. Some girls who excelled at math or science in elementary school, may curb their enthusiasm and displays of success at these subjects for fear of limiting their popularity or attractiveness as girls (Taylor et al/, 1995; Sadker, 2004). Some boys who were not especially interested in sports previously may begin dedicating themselves to athletics to affirm their masculinity in the eyes of others. Some boys and girls who once worked together successfully on class projects may no longer feel comfortable doing so, or alternatively may now seek to be working partners, but for social rather than academic reasons. Such changes do not affect all youngsters equally, nor affect any one youngster equally on all occasions. An individual may act like a young adult on one day, but more like a child the next. Adolescent Brain The brain undergoes dramatic changes during adolescence. Although it does not get larger, it matures by becoming more interconnected and specialized (Giedd, 2015). The myelination and 227 development of connections between neurons continues. This results in an increase in the white matter of the brain and allows the adolescent to make significant improvements in their thinking and processing skills. Different brain areas become myelinated at different times. For example, the brain’s language areas undergo myelination during the first 13 years. Completed insulation of the axons consolidates these language skills but makes it more difficult to learn a second language. With greater myelination, however, comes diminished plasticity as a myelin coating inhibits the growth of new connections (Dobbs, 2012). Even as the connections between neurons are strengthened, synaptic pruning occurs more than during childhood as the brain adapts to changes in the environment. This synaptic pruning causes the gray matter of the brain, or the cortex, to become thinner but more efficient (Dobbs, 2012). The corpus callosum, which connects the two hemispheres, continues to thicken allowing for stronger connections between brain areas. Additionally, the hippocampus becomes more strongly connected to the frontal lobes, allowing for greater integration of memory and experiences into our decision making. The limbic system, which regulates emotion and reward, is linked to the hormonal changes that occur at puberty. The limbic system is also related to novelty seeking and a shift toward interacting with peers. In contrast, the prefrontal cortex which is involved in the control of impulses, organization, planning, and making good decisions, does not fully develop until the mid-20s. According to Giedd (2015) the significant aspect of the later developing prefrontal cortex and early development of the limbic system is the “mismatch” in timing between the two. The approximately ten years that separates the development of these two brain areas can result in risky behavior, poor decision making, and weak emotional control for the adolescent. When puberty begins earlier, this mismatch extends even further. Teens often take more risks than adults and according to research it is because they weigh risks and rewards differently than adults do (Dobbs, 2012). For adolescents the brain’s sensitivity to the neurotransmitter dopamine peaks, and dopamine is involved in reward circuits, so the possible rewards outweighs the risks. Adolescents respond especially strongly to social rewards during activities, and they prefer the company of others their same age. Chein et al. (2011) found that peers sensitize brain regions associated with potential rewards. For example, adolescent drivers make risky driving decisions when with friends to impress them, and teens are much more likely to commit crimes together in comparison to adults (30 and older) who commit them alone (Steinberg et al., 2017). In addition to dopamine, the adolescent brain is affected by oxytocin which facilitates bonding and makes social connections more rewarding. With both dopamine and oxytocin engaged, it is no wonder that adolescents seek peers and excitement in their lives that could end up actually harming them. 228 Because of all the changes that occur in the adolescent brain, the chances for abnormal development can occur, including mental illness. In fact, 50% of the mental illness occurs by the age 14 and 75% occurs by age 24 (Giedd, 2015). Additionally, during this period of development the adolescent brain is especially vulnerable to damage from drug exposure. For example, repeated exposure to marijuana can affect cellular activity in the endocannabinoid system. Consequently, adolescents are more sensitive to the effects of repeated marijuana exposure (Weir, 2015). However, researchers have also focused on the highly adaptive qualities of the adolescent brain which allow the adolescent to move away from the family towards the outside world (Dobbs, 2012; Giedd, 2015). Novelty seeking and risk taking can generate positive outcomes including meeting new people and seeking out new situations. Separating from the family and moving into new relationships and different experiences are actually quite adaptive for society. Adolescent Sleep According to the National Sleep Foundation (NSF) (2016), adolescents need about 8 to 10 hours of sleep each night to function best. The most recent Sleep in America poll in 2006 indicated that adolescents between sixth and twelfth grade were not getting the recommended amount of sleep. On average adolescents only received 7 ½ hours of sleep per night on school nights with younger adolescents getting more than older ones (8.4 hours for sixth graders and only 6.9 hours for those in twelfth grade). For the older adolescents, only about one in ten (9%) get an optimal amount of sleep, and they are more likely to experience negative consequences the following day. These include feeling too tired or sleepy, being cranky or irritable, falling asleep in school, having a depressed mood, and drinking caffeinated beverages (NSF, 2016). Additionally, they are at risk for substance abuse, car crashes, poor academic performance, obesity, and a weakened immune system (Weintraub, 2016). Troxel et al. (2019) found that insufficient sleep in adolescents is a predictor of risky sexual behaviors. Reasons given for this include that those adolescents who stay out late, typically without parental supervision, are more likely to engage in a variety of risky behaviors, including risky sex, such as not using birth control or using substances before/during sex. An alternative explanation for risky sexual behavior is that the lack of sleep negatively affects impulsivity and decision-making processes. Figure 6.7 Source Why do adolescents not get adequate sleep? In addition to known environmental and social factors, including work, homework, media, technology, and socializing, the adolescent brain is also a factor. As adolescent go through puberty, their circadian rhythms change and push back their sleep time until later in the evening (Weintraub, 2016). This biological change not only keeps adolescents awake at night, it makes it difficult for them to wake up. When they are awake too early, their brains do not function optimally. Impairments are noted in attention, academic achievement, and behavior while increases in tardiness and absenteeism are also seen. 229 To support adolescents’ later sleeping schedule, the Centers for Disease Control and Prevention recommended that school not begin any earlier than 8:30 a.m. Unfortunately, over 80% of American schools begin their day earlier than 8:30 a.m. with an average start time of 8:03 a.m. (Weintraub, 2016). Psychologists and other professionals have been advocating for later school times, and they have produced research demonstrating better student outcomes for later start times. More middle and high schools have changed their start times to better reflect the sleep research. However, the logistics of changing start times and bus schedules are proving too difficult for some schools leaving many adolescent vulnerable to the negative consequences of sleep deprivation. Troxel et al. (2019) cautions that adolescents should find a middle ground between sleeping too little during the school week and too much during the weekends. Keeping consistent sleep schedules of too little sleep will result in sleep deprivation but oversleeping on weekends can affect the natural biological sleep cycle making it harder to sleep on weekdays. Adolescent Sexual Activity By about age ten or eleven, most children experience increased sexual attraction to others that affects social life, both in school and out (McClintock & Herdt, 1996). By the end of high school, more than half of boys and girls report having experienced sexual intercourse at least once, though it is hard to be certain of the proportion because of the sensitivity and privacy of the information. (Center for Disease Control, 2004; Rosenbaum, 2006). Adolescent Pregnancy: As can be seen in Figure 6.8, in 2018 females aged 15–19 years experienced a birth rate (live births) of 17.4 per 1,000 women. The birth rate for teenagers has declined by 58% since 2007 and 72% since 1991, the most recent peak (Hamilton, Joyce, Martin, & Osterman, 2019). It appears that adolescents seem to be less sexually active than in previous years, and those who are sexually active seem to be using birth control (CDC, 2016). Figure 6.8 Source Risk Factors for Adolescent Pregnancy: Miller et al. (2001) found that parent/child closeness, parental supervision, and parents' values against teen intercourse (or unprotected intercourse) decreased the risk of adolescent pregnancy. In contrast, residing in disorganized/dangerous neighborhoods, living in a lower SES family, living with a single parent, having older sexually 230 active siblings or pregnant/parenting teenage sisters, early puberty, and being a victim of sexual abuse place adolescents at an increased risk of adolescent pregnancy. Consequences of Adolescent Pregnancy: After the child is born life can be difficult for a teenage mother. Only 40% of teenagers who have children before age 18 graduate from high school. Without a high school degree her job prospects are limited, and economic independence is difficult. Teen mothers are more likely to live in poverty, and more than 75% of all unmarried teen mother receive public assistance within 5 years of the birth of their first child. Approximately, 64% of children born to an unmarried teenage high-school dropout live in poverty. Further, a child born to a teenage mother is 50% more likely to repeat a grade in school and is more likely to perform poorly on standardized tests and drop out before finishing high school (March of Dimes, 2012). Research analyzing the age that men father their first child and how far they complete their education have been summarized by the Pew Research Center (2015) and reflect the research for females. Among dads ages 22 to 44, 70% of those with less than a high school diploma say they fathered their first child before the age of 25. In comparison, less than half (45%) of fathers with some college experience became dads by that age. Additionally, becoming a young father occurs much less for those with a bachelor’s degree or higher as just 14% had their first child prior to age 25. Like men, women with more education are likely to be older when they become mothers. Eating Disorders Figure 6.9 According to the DSM-5-TR (American Psychiatric Association, 2022), eating disorders are characterized by a persistent disturbance of eating or eating-related behavior that results in the altered consumption or absorption of food and that significantly impairs physical health or psychosocial functioning. Although eating disorders can occur in children and adults, they frequently appear during the teen years or young adulthood (National Institute of Mental Health (NIMH), 2016). Eating disorders affect both genders, although rates among women are 2½ times greater than among men. Similar to women who have eating disorders, men also have a distorted sense of body image, including muscle dysmorphia, which is an extreme desire to increase one’s muscularity (Bosson et al., 2019). The prevalence of eating disorders in the United States is similar among Non-Hispanic Whites, Hispanics, African-Americans, and Asians, with the exception that anorexia nervosa is more common among Non-Hispanic Whites (Hudson et al., 2007; Wade et al., 2011). Source Risk Factors for Eating Disorders: Because of the high mortality rate, researchers are looking into the etiology of the disorder and associated risk factors. Researchers are finding that eating disorders are caused by a complex interaction of genetic, biological, behavioral, psychological, and social factors (NIMH, 2016). Eating disorders appear to run in families, and researchers are working to identify DNA variations that are linked to the increased risk of developing eating 231 disorders. Researchers from King’s College London (2019) found that the genetic basis of anorexia overlaps with both metabolic and body measurement traits. The genetic factors also influence physical activity, which may explain the high activity level of those with anorexia. Further, the genetic basis of anorexia overlaps with other psychiatric disorders. Researchers have also found differences in patterns of brain activity in women with eating disorders in comparison with healthy women. The main criteria for the most common eating disorders: Anorexia nervosa, bulimia nervosa, and binge-eating disorder are described in the DSM-5-TR (American Psychiatric Association, 2022) and listed in Table 6.1. Table 6.1 DSM-5-TR Eating Disorders Anorexia Nervosa  Restriction of energy intake leading to a significantly low body weight  Intense fear of gaining weight  Disturbance in one’s self-evaluation regarding body weight Bulimia Nervosa Binge-Eating Disorder  Recurrent episodes of binge eating  Recurrent inappropriate compensatory behaviors to prevent weight gain, including purging, laxatives, fasting or excessive exercise  Self-evaluation is unduly affected by body shape and weight  Recurrent episodes of binge eating  Marked distress regarding binge eating  The binge eating is not associated with the recurrent use of inappropriate compensatory behavior Health Consequences of Eating Disorders: For those suffering from anorexia, health consequences include an abnormally slow heart rate and low blood pressure, which increases the risk for heart failure. Additionally, there is a reduction in bone density (osteoporosis), muscle loss and weakness, severe dehydration, fainting, fatigue, and overall weakness. Anorexia nervosa has the highest mortality rate of any psychiatric disorder (Arcelus et al., 2011). Individuals with this disorder may die from complications associated with starvation, while others die of suicide. In women, suicide is much more common in those with anorexia than with most other mental disorders. The binge and purging cycle of bulimia can affect the digestives system and lead to electrolyte and chemical imbalances that can affect the heart and other major organs. Frequent vomiting can cause inflammation and possible rupture of the esophagus, as well as tooth decay and staining from stomach acids. Lastly, binge eating disorder results in similar health risks to obesity, including high blood pressure, high cholesterol levels, heart disease, Type II diabetes, and gall bladder disease (National Eating Disorders Association, 2016). 232 Figure 6.10 Source Eating Disorders Treatment: To treat eating disorders, adequate nutrition and stopping inappropriate behaviors, such as purging, are the foundations of treatment. Treatment plans are tailored to individual needs and include medical care, nutritional counseling, medications (such as antidepressants), and individual, group, and/or family psychotherapy (NIMH, 2016). For example, the Maudsley Approach has parents of adolescents with anorexia nervosa be actively involved in their child’s treatment, such as assuming responsibility for feeding the child. To eliminate binge eating and purging behaviors, cognitive behavioral therapy (CBT) assists sufferers by identifying distorted thinking patterns and changing inaccurate beliefs
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Let’s break this down! I’ll give you a study guide covering asexual reproduction, sexual reproduction (in humans and plants), and Mendelian genetics — then I’ll create a test for you. ⸻ Study Guide for Asexual Reproduction, Sexual Reproduction, and Mendelian Genetics ⸻ I. Asexual Reproduction • Definition: Involves a single parent, producing offspring genetically identical to the parent (clones). • Types of Asexual Reproduction: • Binary Fission: Simple cell division (e.g., bacteria). • Budding: New organism grows from a bud on the parent (e.g., yeast, hydra). • Fragmentation/Regeneration: Organism splits, and each part grows into a new organism (e.g., starfish). • Vegetative Propagation: New plants grow from parts of the parent plant (e.g., runners in strawberries). • Parthenogenesis: Offspring develop from unfertilized eggs (e.g., some lizards, insects). • Pros and Cons: • Pros: Fast, no need for a mate, energy-efficient. • Cons: No genetic variation, susceptible to environmental changes. ⸻ II. Sexual Reproduction (Humans & Plants) Humans: • Process: • Gametes (sperm and egg) produced by meiosis. • Fertilization forms a zygote (diploid cell). • Male Reproductive System: Testes, epididymis, vas deferens, prostate, urethra, penis. • Female Reproductive System: Ovaries, fallopian tubes, uterus, cervix, vagina. • Hormonal Regulation: • Male: Testosterone (sperm production, secondary characteristics). • Female: Estrogen & progesterone (menstrual cycle, pregnancy). Plants: • Process: Alternation of generations (sporophyte & gametophyte stages). • Pollination: Transfer of pollen to stigma. • Fertilization: Sperm (from pollen) fuses with egg in ovule. • Structures: Stamen (male), carpel/pistil (female). • Seed & Fruit Development: Fertilized ovules become seeds; ovary becomes fruit. ⸻ III. Mendelian Genetics • Gregor Mendel’s Experiments: Pea plants, discovered inheritance patterns. • Key Concepts: • Genes & Alleles: Genes determine traits, alleles are gene variants. • Dominant vs. Recessive Alleles: Dominant alleles mask recessive ones. • Homozygous vs. Heterozygous: Same alleles (AA or aa) vs. different alleles (Aa). • Laws of Inheritance: • Law of Segregation: Allele pairs separate during gamete formation. • Law of Independent Assortment: Genes for different traits sort independently. • Genetic Crosses: Punnett squares, monohybrid/dihybrid crosses. • Probability & Ratios: Phenotypic/genotypic ratios. • Non-Mendelian Inheritance: Incomplete dominance, codominance, multiple alleles, polygenic traits, sex-linked traits. ⸻ AP Biology Practice Test Total Questions: 30 (Multiple Choice) Section 1: Asexual Reproduction (6 questions) 1. Which form of asexual reproduction involves an organism splitting into two identical cells? a) Budding b) Fragmentation c) Binary fission d) Parthenogenesis 2. Which organism commonly reproduces through budding? a) Bacteria b) Starfish c) Hydra d) Fern 3. A disadvantage of asexual reproduction is: a) Slow reproduction rate b) High genetic diversity c) Vulnerability to environmental changes d) Requirement of a mate 4. Which plant structure is involved in vegetative propagation? a) Petal b) Stigma c) Runner d) Anther 5. Parthenogenesis involves: a) Fertilized eggs developing into offspring b) Unfertilized eggs developing into offspring c) Fusion of gametes d) Regeneration of lost body parts 6. What is the primary benefit of asexual reproduction in stable environments? a) Genetic variation b) Rapid population growth c) Evolutionary adaptability d) Reduced mutation rates ⸻ Section 2: Sexual Reproduction (8 questions) 7. In humans, fertilization typically occurs in the: a) Uterus b) Vagina c) Ovary d) Fallopian tube 8. The male gamete in plants is contained in the: a) Ovule b) Anther c) Pollen grain d) Stigma 9. Which hormone triggers ovulation? a) Testosterone b) Progesterone c) Luteinizing hormone (LH) d) Estrogen 10. The female gametophyte in flowering plants is the: a) Ovary b) Pollen tube c) Embryo sac d) Sepal 11. Which part of the male reproductive system produces sperm? a) Epididymis b) Vas deferens c) Testes d) Prostate gland 12. The process where pollen is transferred from anther to stigma is: a) Germination b) Pollination c) Fertilization d) Sporulation 13. What structure develops into a seed after fertilization in plants? a) Ovule b) Ovary c) Stamen d) Pistil 14. Which term describes the fusion of egg and sperm to form a zygote? a) Gametogenesis b) Meiosis c) Fertilization d) Pollination ⸻ Section 3: Mendelian Genetics (16 questions) 15. Who is considered the “Father of Genetics”? a) Charles Darwin b) Gregor Mendel c) Rosalind Franklin d) James Watson 16. The physical expression of a trait is called: a) Genotype b) Phenotype c) Allele d) Chromosome 17. An organism with the genotype Aa is: a) Homozygous dominant b) Homozygous recessive c) Heterozygous d) Diploid 18. A Punnett square shows: a) The process of DNA replication b) Possible genetic combinations of offspring c) Chromosome number in gametes d) Evolutionary relationships 19. The expected phenotypic ratio for a monohybrid cross is: a) 1:2:1 b) 9:3:3:1 c) 3:1 d) 4:0 20. Which of Mendel’s laws states that allele pairs separate during gamete formation? a) Law of Independent Assortment b) Law of Segregation c) Law of Dominance d) Law of Inheritance 21. Incomplete dominance results in: a) Blended traits b) Both traits expressed equally c) One trait completely masking another d) A 9:3:3:1 ratio 22. A cross between two heterozygous individuals (Aa x Aa) produces what genotypic ratio? a) 3:1 b) 1:2:1 c) 9:3:3:1 d) 2:2 23-30
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Primary adrenal insufficiency = problem at level of adrenal glands Causes? Addison’s disease Pathophys? Autoimmune destruction of the adrenal glands Associated with hyperpigmentation POMC is precursor to both ACTH and MSH PAI → lack of negative feedback → high ACTH Lab findings? ACTH high Aldosterone low Destruction of zona glomerulosa Renin high Hypotension → RAAS activation Electrolytes Na+ low, K+ high CBC Eosinophils high Pathophys? Glucocorticoids → eosinophil apoptosis. Lack of glucocorticoids cause eosinophilia. Dx? Cosyntropin testing → no rise in cortisol Adrenal glands aren’t working, so no response to ACTH. Tx? prednisone/hydrocortisone/dexamethasone + fludrocortisone (mineralocorticoid) Stress-dose steroids for surgery, serious illness, etc. Secondary adrenal insufficiency = problem at level of pituitary, reduced ACTH release Causes? MC is prolonged steroid use → ACTH suppression Sheehan’s syndrome (infarction of pituitary) pregnancy Pituitary tumors (ACTH-producing tumor) Lab findings? ACTH low Anterior pituitary is being inhibited Aldosterone normal Zona glomerulosa under control of RAAS system Renin normal Electrolytes Na+ & K+ unaffected (Aldosterone levels are normal) CBC Neutrophilia due to demargination (if pt was recently taking steroids) Dx? Cosyntropin testing → rise in cortisol Adrenal gland is functional Tx? Glucocorticoids Do not need to replace mineralocorticoids since adrenals are functional and aldosterone is under RAAS control Stress-dose steroids for surgery, serious illness, etc. AI with a history of nuchal rigidity and purpuric skin lesions → Waterhouse-Friedrichson syndrome Pathophys? AI 2/2 hemorrhagic infarction of the adrenal glands in the context of Neisseria meningitidis infection Adrenal synthesis enzymes If the enzyme starts with 1 → HTN (high mineralocorticoids) and hypokalemia If the second # is 1 → virilization (high androgens) E.g. 11-beta hydroxylase deficiency → HTN & virilization E.g. 21 hydroxylase deficiency → virilization only E.g. 17-alpha hydroxylase deficiency → HTN only B12 deficiency Where does B12 come from? Animal products VS folic from plants Physiology R factor in saliva binds to B12 and protects it from acidity in the stomach. R factor protector -B12 travels to the duodenum. Parietal cells produce intrinsic factor, which travels to the duodenum. Pancreatic enzymes cleave B12 from R factor and B12 then binds IF. B12-IF complex is reabsorbed in the terminal ileum Reabsorption where? Terminal ileum Causes of B12 deficiency Extreme vegan Pernicious anemia Pancreatic enzyme deficiency Cystic Fibrosis Can’t cleave B12 from R factor Crohn’s Affects terminal ileum Lab markers Homocysteine HIGH MethlyManoicAcid HIGH Presentation? Megaloblastic anemia Subacute combined degeneration (of dorsal columns + lateral corticospinal tract) Peripheral neuropathy Dx of pernicious anemia? anti-IF Ab Folate deficiency Where does folate come from? Leafy things Causes of folate deficiency Poor diet (e.g. alcoholics, elderly) Phenytoin Lab markers Homocysteine HIGH MMA normal Presentation? Megaloblastic anemia Prophylaxis in HIV+ patients CD4 < 200 → PCP TMP-SMX, inhaled pentamidine, dapsone, atovaquone CD4 < 100 → Toxoplasm Treat: TMP-SMX CD4 < 50 → MAC Treat: Azithromycin If live in endemic area, CD4 < 250 → Coccidioides Immitis E.g. Arizona, Nevada, Texas, California Treat: Itraconazole If live in endemic area, CD4 < 150 → Histoplasma Capsulatum E.g. Kentucky, Ohio, Missouri Treat: Itraconazole Diabetes insipidus Dx? Water deprivation test Measure serum osmolality & urine osmolality Deprive pt of water Remeasure serum osmolality & urine osmolality If urine osmolality doesn’t go up → suspect DI Central DI → deficiency of ADH Pathophys? Supraoptic nucleus not making enough ADH Dx? Give desmopressin → urine osmolality increases significantly Nephrogenic DI → kidneys are not responding to ADH Dx? Give desmopressin → urine osmolality doesn’t change much Tx? Hydrochlorothiazide Unless 2/2 lithium, use amiloride or triametere Causes? Lithium SSRIs Carbamazepine Demeclocycline Tx of normovolemic hypernatremia? D5W to correct free water deficit Divine says NS, but most other resources I found said correct free water deficit Tx of hypovolemic hypernatremia? Give NS first until normal volume, then give D5W Consequence of correcting hypernatremia too rapidly? Cerebral edema Osteoarthritis Presentation? Old person with joint pain that gets worse throughout the day Risk Factr? Obesity vs decreases osteoporosis Imaging findings? Joint space narrowing Subchondral sclerosis Subchondral cysts Osteophytes Arthrocentesis findings? <2000 cells Tx? 1st line acetaminophen 2nd line NSAID (e.g. naproxen) 3rd line joint replacement surgery Returned from a business conference 1 week ago + Fever + Nonproductive cough + Abdominal pain + Hyponatremia → Legionella Dx? Urine antigen Tx? FQ or macrolide MaCroLide mnemonic = Mycoplasma, Chlamydia, Legionella What are the common causes of atypical PNA? Mycoplasma, Legionella, Chlamydia MC cause? Mycoplasma CXR findings? Interstitial infiltrates HY associations C. Psittaci → birds C. Burnetii → cows, goats, sheet Mycoplasma → college student w/ walking pneumonia Midsystolic click heard best at the apex. → mitral valve prolapse “Stenosnap & Proclick” Risk Factor? Connective tissue disease Marfarn Ehlers-Danlos ADPKD bilateral renal masses Classic demographic? Young woman psychiatric Pathophys? Myxomatous degeneration MVP vs aortic dissection: cystic medial necrosis Exam maneuvers Anything that increase amount of blood in LV → murmur softer Increase preload Increase afterload Anything that decreases amount of blood in LV → murmur louder Dx? Echo Scaly, itchy skin with yellowish crusting in the winter. → seborrheic dermatitis Tx? Topical antifungals e.g. ketoconazole or selenium sulfide shampoo Classic disease distribution? Hair → e.g. cradle cap Eyebrows Episodic/intermittent HTN + HA → pheochromocytoma Genetic disease associations MEN2A MEN2B VHL in brain (hemangioma) NF-1 growth in skin Pathophys? Catecholamine-secreting tumor Location? Adrenal medulla Posterior mediastinum Organ of Zuckerkandl (chromaffin cells along the aorta) Dx? 1st step: urine metanephrines If elevated → CT abdomen If nothing found on CT → MIBG scan Tx? Alpha blocker (e.g. phenoxybenzamine, phenotaline) THEN beta blocker Most common cause of a Lower GI Bleed in the elderly → diverticulosis Dx? Colonoscopy or barium enema Recall that you acutely do a CT scan for diverticulitis, then 6 weeks later colonoscopy to r/o cancer Ppx? Eat fiber Megaloblastic anemias Blood smear findings? Hypersegmented neutrophils MCV > 100 Classic patient demographic with folate deficiency? Alcoholics Elderly person with poor nutrition Folate synthesis inhibitors Pt with molar pregnancy → methotrexate Pulmonary issue? Pulmonary fibrosis HIV+ pt with ring-enhancing lesions → pyrimethamine-sulfadiazine Pyrimethamine inhibits DHFR AIDS pt on ppx for toxo → TMP-SMX TMP inhibits DHFR Use of leucovorin? Rescue bone marrow in setting of methotrexate toxicity Mechanism? Folinic acid analog CMV presentations Esophagitis → linear ulcers Colitis → post-transplant pt Retinitis → HIV pt with CD4 < 50 Congenital CMV → periventricular calcifications + hearing loss calcifications elsewhere → toxo Histology? Owl’s eye intranuclear inclusions Tx? Gancicyclovir Resistance? UL97 kinase mutation Tx for resistance? foscarnet CD4 < 200 + severe peripheral edema + frothy urine. → FSGS in HIV pt Variant classic in HIV+ pts? Collapsing variant Tx? Steroids + cyclophosphamide + ACE-I Indinavir AE? Kidney stones triad of fever, rash, and eosinophiluria → acute interstitial nephritis Drugs cause? Penicillins Tx? Stop the drug! Can add steroids if severe Vitamin D metabolism Liver converts Vit D to calcidiol (25OH-Vit D). Calcidiol goes to kidney. Alpha-1 hydroxylase converts calcidiol to calcitriol (1,25-OH Vit D). Common causes of Vitamin D deficiency CKD → 1-alpha hydroxyalse deficiency Liver disease → can’t make calcidiol CF → malabsorption Crohn’s → malabsorption Osteomalacia vs Rickets Osteomalacia in adults Rickets in kids Tx? Calcium + vit D Lab findings? Ca++ low Phos low Low in liver disease High in kidney disease (kidneys can’t get rid of phos) PTH high (2ary hyperpara) vs liver dx PTH low Alk phos Aspiration pneumonia Risk Factor? Alcoholism Dementia Neuromuscular problems (e.g. MG, ALS) Bugs? Anaerobes foul smelling Bacteroides FUsobacterium Peptostreptococcus Klebsiella → currant jelly sputum alcoholic Tx? Clindamycin CURB-65 criteria Purpose? Who to admit Cutoff? 2+ → hospitalize C = confusion U = uremia (BUN > 20) R = RR > 30 B = BP < 90/60 Age > 65 Drugs commonly used in PNA treatment Ceftriaxone Levofloxacin fluoroquinolone Macrolides - great for atypical PNA Pharmacological management of pulmonary arterial HTN Endothelin antagonists Bosentan ambrisentan PDE-5 inhibitors Sildenafil Tadalafil Prostacyclin analogs Iloprost Epoprostenol Treprostinil Causes? Young female → idiopathic PAH Mutation? BMPR2 55 yo F presents with a 5 week history of a rash on her forehead. PE reveals scaly macules with a sandpaper texture. → actinic keratosis Risk Factor? Sun exposure Tx? Topical 5-FU Possible dangerous sequelae? Squamous cell carcinoma Most likely disease sequelae? Resolution 1ary hyperparathyroidism 2ary hyperparathyroidism 3ary hyperparathyroidism Autonomous PTH production Causes? Adenoma Parathyroid hyperplasia PTH high Ca++ high Phos low Low Ca++ → PTH production Causes? CKD PTH high Ca++ low Phos high PTH production despite normalized of Ca++ levels Causes? CKD s/p transplant PTH high Ca++ high Phos low Tx? Parathyroidectomy (remove 3.5 glands) Cinacalcet (CSR modulator) Hypercalcemia Presentation? bones, stones, groans, psychic overtones Tx? 1st step: Normal Saline Hypercalcemia of malignancy → bisphosphonates EKG finding? Shortened QT Periumbilical pain that migrates to the right lower quadrant. → appendicitis PE findings? McBurney’s point tenderness Psoas sign (flex hip pain) Obturator sign (pain with internal rotation of hip) Rovsing’s sign (palpation of LLQ → pain in RLQ) Dx? CT scan Pregnant → US Kid → US Tx? Surgery Classic drug and viral causes of aplastic anemia. Drugs? Carbamazepine Chloramphenicol Viral? Parvovirus B19 (single stranded DNA virus) Fanconi anemia Pathophys? Problems with DNA repair Fanconi anemia vs Fanconi syndrome Fanconi anemia → cytopenias + thumb anomalies + short stature + cafe-au-lait spots Fanconi syndrome → type 2 RTA (proximal) CD4 count of 94 + MRI revealing ring enhancing lesions in the cortex → toxoplasmosis Tx? Pyrimethamine-sulfadiazine Rescue agent for pt who becomes leukopenic with treatment? leucovorin Who should get steroids? Increased ICP For PCP pneumonia: O2 sat < 92 PaO2 < 70 A-a gradient > 35 Ppx? TMP-SMX for CD4 < 100 Congenital toxo Hydrocephalus Chorioretinitis Intracranial calcifications Classic methods of transmission? handling cat litter Lupus nephritis Associated autoantibody? anti-dsDNA Classic “immunologic” description? “Full house” pattern Tx? Steroids + cyclophosphamide Osteoporosis Screening population? women > 65 Screening modality? DEXA scan Dx? T-score < -2.5 Risk Factor? Postmenopauseal Low BMI Smoking Alcohol Preventive strategies? Weight bearing exercise Smoking cessation Reduce alcohol consumption Tx? 1st line: bisphosphonates + Ca/Vit D supplementation Raloxifene (SERM) Agonist in bone Blocker Antagonist in breast Classic locations of osteoporotic fractures Vertebral compression fracture Hip fracture Name the PNA Red currant jelly sputum. → Klebsiella Rust colored sputum. → Strep pneumo PNA in an alcoholic. → Klebsiella Post viral PNA with a cavitary CXR lesion. → Staph aureus PNA in a patient that has chronically been on a ventilator. → Pseudomonas MC cause of Community Acquired Pneumonia. → Strep pneumo Pharmacological management of MRSA. Vancomycin Clindamycin Linezolid Ceftaroline (5th gen cephalosporin) Tigecycline, tertracycline Pharmacological management of Pseudomonas. Ceftazidime (only 3rd gen cephalosporin) Cefepime (4th gen cephalosporin) Pip-tazo Fluoroquinolones Carbapenems Aztreonam Aminoglycosides JVD and exercise intolerance in a patient with a recent history of an URI. → dilated cardiomyopathy 2/2 viral myocarditis MC cause? Coxsackie B VS Coxsackie A: Hand foot mouth dx Drug causes myocarditis Clozapine Anthracyclines Prevention? Dexrazoxane (iron chelator) Trastuzumab reversible tx for breast cancer Classic cause in a patient with recent history of travel to S. America? Chagas T. Cruzi Potential sequelae? Achalasia Dilated cardiomyopathy Megacolon (2/2 degeneration of myenteric plexus) Massive skin sloughing (45% BSA) in a patient that was recently started on a gout medication? TEN Dx? <10% BSA → SJS >30% BSA → TEN Tx? STOP the drug IVF Topical abx to prevention infection Tetany and a prolonged QT interval in a patient with recent surgical treatment of follicular thyroid carcinoma. → hypocalcemia due to removal of parathyroids Recurrent viral infections + QT prolongation + tetany → DiGeorge syndrome Pathophys? Failure of development of 3rd/4th pharyngeal pouches Trousseau and Chvostek signs. Trousseau → inflation of BP cuff causes carpopedal spasm Chvostek → taping on cheek causes facial muscle spasm Hypocalcemia that is refractory to repletion → consider hypomagnesemia Electrolyte/drug causes of prolonged QT intervals Electrolytes? Hypocalcemia Hypomagnesemia Hypokalemia Drugs? Macrolides FloroQunlones Haloperidol Ondensatron Methadone Hypoalbuminemia and Ca balance Hypoalbumenia → decrease in total body Ca++, no change in ionized Ca++ Drop of 1 in albumin → add 0.8 to Ca++ Abdominal pain radiating to the back → acute pancreatitis Causes? #1 = Gallstones #2 = Alcohol Hypertriglyceridemia Hypercalcemia Scorpion sting Handlebar injuries Lab markers? Lipase - most sensitive Amylase Physical exam signs in pancreatitis. Cullen’s sign = periumbilical ecchymosis Grey Turner sign = flank ecchymosis Tx? NPO + IVF + pain control Meperidine is a good agent because it doesn’t cause sphincter of Oddi spasms Management of gallstone pancreatitis Dx? US then ERCP Tx? DELAYED cholecystectomy What if the patient becomes severely hypoxic with a CXR revealing a “white out” lung? ARDS noncardiogenic pulm edema PCWP? <18 mmHg NORMAL 20 yo M with red urine in the morning + hepatic vein thrombosis + CBC findings of hemolytic anemia. → paroxysmal nocturnal hemoglobinuria Pathophys? Defect in GPI anchors, which attach CD55 and CD59 to cell (they prevent complement from destroying RBC) Sleep → hypoventilation → mild respiratory acidosis → activation of complement cascade Gene mutation? PIGA Dx? Flow cytometry Tx? Eculizumab (terminal complement inhibitor) Vaccine required? pnemococal Neisseria meningitidis Chronic diarrhea and malabsorption in a HIV+ patient + detection of acid fast oocysts in stool. → cryptosporidium parvum Acid-fast organisms Cryptosporidium TB MAC Nocardia Dx? Stool O&P Tx? Nitazoxanide Route of transmission? Contaminated water Muddy brown casts on urinalysis in a patient with recent CT contrast administration (or Gentamicin administration for a life threatening gram -ve infection) → Acute Tubular Necrosis Woman with morning joint stiffness > 1 hr → Rhematoid Arthritis. Antibodies? Rheum Factor (IgM against IgG) anti-CCP - more specific HLA? DR4 Pathophys? IgM constant region activates complement → inflammation → formation of pannus (hypertrophied synovium) → damage to cartilage and bone Caplan syndrome = RA + pneumoconiosis Felty syndrome = RA + neutropenia + splenomegaly (“RANS”) Classic hand/finger findings/distribution? MCP & PIP joints of hands (DIP joints spared) Imaging findings? Symmetric joint space narrowing Tx? Methotrexate (DMARDs) If no response → TNF alpha inhibitor (e.g. infliximab) Required testing prior to starting methotrexate? PFTs Required testing prior to starting infliximab? TB Hep B/Hep C Differentiating Strep pharyngitis from Infectious Mononucleosis LND distribution Anterior cervical → Strep Posterior cervical → Mono Disease onset Acute → Strep Over weeks → Mono Organ involvement Splenomegaly → Mono Pt with sore throat takes amoxicillin and gets rash → mono NOT allergic rxn! CENTOR criteria C = absence of Cough E = tonsillar Exudates N = nodes/anterior cervical lymphadenopathy T = temp (fever) OR <15 → +1 >=45 → -1 Using CENTOR score 0/1 → don’t test, don’t treat 2/3 → rapid antigen test Positive → treat Negative → throat culture 4/5 → treat empirically Tx of Strep pharyngitis? Amoxillcin If PCN allergic → azithromycin Potential sequelae of Strep pharyngitis RF - preventable with abx PSGN Endocarditis MC cause of endocarditis? IVDU Bug? Staph aureus Valve? tricuspid Prosthetic valve endocarditis Bug? Staph epidermidis Endocarditis after dental procedure? Viridans group streptococci Strep viridans, Strep mitis, Strep mutans, Strep sanguineous Patient with malar rash and echo showing vegetations on both sides of the mitral valve → Libman-Sacks endocarditis Presentation? Fever + night sweats + new murmur Splinter hemorrhages Roth spots (retinal hemorrhages) Painless Janeway lesions + painful Osler nodes (immune phenomenon) Dx? 1st step: blood cultures TEE Tx? Abx that include Staph aureus coverage (e.g. vancomycin) for WEEKS Bugs implicated in culture negative endocarditis HACEK H = haemophilus A = actinobacillus C = cardiobacterium E = eikenella K = kingella Coxiella burnetii Blood cultures in a patient with endocarditis reveal S. Bovis (or S. Gallolyticus bacteremia). NBS? Colonoscopy Who needs antibiotic prophylaxis? Hx endocarditis Prosthetic valve Unrepaired cyanotic congenital dz Heart transplant with valve dysfunction Erythematous salmon colored patch with silvery scale on the elbows and knees. → psoriasis Tx? Topical steroids If this patient presents with joint pain (especially in the fingers)? Psoriatic arthritis Imaging? Pencil-and-cup deformity Tx? NSAIDs T of 104 + tachycardia + new onset Afib in a patient with a history of Graves disease. → thyroid storm Lab findings? TSH low T3/T4 high Tx? 1st step: propranolol 2nd step: PTU Then: Prednisone Potassium iodide (Lugul’s solution) Wolff-Chaikoff effect → large amounts of iodine inhibit thyroid hormone synthesis Biopsy revealing tennis racket shaped structures in cells of immune origin. → Langerhans cell histiocytosis Electron microscopy? Birbeck granules (tennis rackets) Marker? S100 Small bowel obstruction in a HIV patient with purple macules on the face, arms, and lower extremities. → Kaposi’s sarcoma Bug? HHV8 Tx? HAART Pathophys of vascular lesions? Overexpression of VEGF Fever + rash + eosinophiluria 10 days after a patient started an antistaphylococcal penicillin. → acute interstitial nephritis Tx? STOP drug + steroids SLE SOAP BRAIN MD S = serositis O = oral ulcers A = arthritis P = photosensitivity B = blood disorders (cytopenias) R = renal A = ANA/anti-dsDNA I = immunologic N = neurologic findings M = malar rash D = discoid rash Type 2 vs 3 HSRs in lupus Type 2 → cytopenias Type 3 → all other manifestations Lupus Ab? ANA anti-dsDNA anti-Smith Lupus nephritis → full house pattern on IF Antiphospholipid antibody syndrome → recurrent pregnancy losses Pathophys? Thrombosis of the uteroplacental arteries. MC cause of death in lupus patients? What I’ve read recently: CV disease Per Divine: Treated → infection Untreated → renal dz Also 40x risk MI Endocarditis in lupus pt? Libman-Sacks endocarditis Neonatal 3rd degree heart block → neonatal lupus Maternal autoimmune dz? Sjogren’s SLE Ab? anti-SSA/anti-Ro anti-SSB/anti-La Tx? Steroids Cyclophosphamide Hydroxychloroquine → good for skin lesions Pulmonary abscesses Bugs? Staph Anaerobes Klebsiella RF? Alcoholism Elderly Post-viral pneumonia MC location of aspiration pneumonia? Superior segment of RLL Chest pain worsened by deep inspiration and relieved by sitting up in a patient with a recent MI or elevated creatinine or URI or RA/SLE. → pericarditis EKG findings? Diffuse ST elevations + PR depression PE finding? Friction rub (“scratchy sound on auscultation”) A few days after MI → fibrinous pericarditis Weeks after MI → Dressler’s Tx? NSAIDS Consider adding on colchicine Cardiac tamponade Beck’s triad = hypotension + JVD + muffled heart sounds EKG findings? Electrical alternans Type of shock? Obstructive cardiogenic (Amboss) CO low SVR high PCWP high Tx? Pericardiocentesis or pericardial Pearly lesion with telangiectasias on the ear in a farmer. → Basal Cell Carcinoma MC type skin cancer Location? Upper lip Dx? Biopsy Tx? Mohs surgery Cold intolerance in a 35 yo white F → hypothyroidism MC cause? Hashimoto’s Histology? lymphoid follicles w/ active germinal centers Lab findings? TSH high T3/T4 low Ab? anti-TPO Anti-thyroglobulin HLA? DR3/DR5 Tx? Levothyroxine Future complication? thyroid lymphoma Massive hematemesis in a patient with a history of chronic liver disease. → ruptured varices Pathophys? L gastric vein has anastomosis with azygos veins. Increased portal pressure → backward flow from L gastric veins to azygous vein (which empties into SVC). Acute tx? IVF + octreotide + ceftriaxone/cipro + EGD w/ ligation/banding Do NOT give a beta blocker for acute tx Prophalaxsis? Beta blocker + spironolactone Other manifestations of elevated portal pressures Caput medusa Internal hemorrhoids Tx for cirrhotic coagulopathies? FFP If uremia → give desmopressin Note: Desmopressin = ADH analog → so, it can cause AE of hyponatremia 2/2 SIADH Hemophilia A Pathophys? deficiency of factor 8 Inheritance? XLR Coag labs? Bleeding time normal PTT HIGH b/c clotting problem PT normal Hemophilia B Pathophys? deficiency of factor 9 Inheritance? XLR Coag labs? Bleeding time normal PTT HIGH PT normal Hemophilia C Pathophys? deficiency of factor 11 Inheritance? AR Coag labs? Bleeding time normal PTT HIGH PT normal Bernard Soulier Syndrome Pathophys? Deficiency of GpIb Coag labs? Bleeding time HIGH PTT normal PT normal Glanzmann Thrombasthenia Pathophys? Deficiency of GpIIbIIIa Coag labs? Bleeding time HIGH PTT normal PT normal Von Willebrand’s disease Pathophys? Deficiency of vWF Inheritance? AD Coag labs? Bleeding time HIGH PTT HIGH vWF is a protecting group for factor 8 PT normal ITP Pathophys? Ab against GpIIbIIIa Classic pt? Pt with SLE Tx? Observation Steroids IVIG Splenectomy TTP Pathophys? Deficiency in ADAMTS13 enzyme → cannot cleave vWF multimers → activation of platelets → thrombosis → thrombocytopenia Presentation? microangiopathic hemolytic anemia + thrombocytopenia + renal failure + fever + neurologic problems Tx? Plasma exchange transfusion****** HUS Bugs? Shigella or E. coli O157:H7 Presentation? Fever+ microangiopathic hemolytic anemia + thrombocytopenia + renal failure + neurologic Platelet deficiency vs coagulation factor bleeds Platelet deficiency → mucosal bleeds, petechiae, heavy menses Coag factor deficiency bleeds → hemarthrosis Why do patients with CKD develop coagulopathy? Uremia → platelet dysfunction Tx? Desmopressin Note: Desmopressin = ADH analog → so, it can cause AE of hyponatremia 2/2 SIADH Exercising caution with transfusion in patients with Bernard Soulier syndrome Do NOT give transfusion that includes platelets They can have an anaphylactic rxn to GpIb (since they don’t have GpIb) Oropharyngeal candidiasis. RF? HIV Chronic ICS use TNF inhibitor Micro finding? Germ tubes at 37 C Tx oral candidiasis? Nystatin swish-and-swallow Tx invasive candidiasis? Amphotericin B Prevention of Amphotericin B toxicity? Liposomal formulation Pleural effusions Light’s criteria (must meet all 3 to be considered transudative!) LDH < 2/3 ULN LOW Pleural LDH/serum LDH < 0.6 LOW Pleural protein/serum protein < 0.5 LOW Causes of transudative effusion CHF Cirrhosis Nephrotic syndrome Note: Per UW 2021: Mechanism of transudate effusion? Decreased pulmonary artery oncotic pressure, e.g. hypoalbuminemia in nephrotic syndrome Increased pulmonary capillary hydrostatic pressure, e.g. volume overload in heart failure Causes of exudative effusion Malignancy Cancer Parapneumonic effusion Tb Note: Per UW 2021: Mechanism of exudate effusion? Inflammatory increased in vascular permeability of membrane (increased flow of interstitial edema into pleural space) Unique cause of both transudative & exudative effusions? PE Classic Pleural Effusion findings? Decreased breath sounds Dullness to percussion Decreased tactile fremitus Tx? Chest tube Chylothorax = lymph in the pleural space Pathophys? Obstruction of thoracic duct or injury to the thoracic duct Pleural fluid findings? High Triglycerides Holosystolic murmur heard best at the apex with radiation to the axilla in a patient with a recent MI. → mitral regurg 2/2 papillary muscle rupture Dx? Echo Why widely split S2? Aortic valve is closing earlier (LV is emptying into both aorta & LA) Maneuvers that increase intensity Increase preload (putting more blood in that can be regurgitated) Increase afterload Decubitus ulcers RF? Elderly Paraplegic Fecal/urinary incontinence Poor nutrition Staging Stage 1 = non-blanchable erythema Tx? Repositioning q2hrs Stage 2 = loss of epidermis + partial loss of dermis Tx? Occlusive dressing superficial Stage 3 = involves entire dermis, extending to subQ fat Does NOT extend past fascia Tx? Surgical debridement Stage 4 = muscle/tendon/bose exposed Tx? Surgical debridement General tx strategies? Repositioning + good nutritional support Marjolin’s ulcer = non-healing wound that is actually squamous cell carcinoma T1DM Pathophys? Autoimmune destruction of pancreas Ab? anti-GAD 65 (glutamic acid decarboxylase) anti-IA2 (islet tyrosine phosphatase 2) Islet cell autoantibodies Insulin autoantibodies Dx? A1c > 6.5% (twice) Fasting BG >= 126 (twice) Oral glucose tolerance test >= 200 (twice) Sxs of DM + random glucose > 200 Tx? Long-acting insulin + mealtime insulin Long-acting Glargine Detemir Rapid-acting Lispro Aspart Glulisine 3 HY complications Nephropathy Retinopathy & cataracts Neuropathy Chronic DM care A1c q3 months Foot exam annually Eye exam annually Microalbumin:Cr ratio annually Nephroprotection in DM? ACE-I GI bleed algorithm 1st step: ABCs + 2 large-bore IVs + IVFs 2nd step: NG lavage Clear fluid → go deeper Blood → UGIB → upper endoscopy Bilious fluid → have ruled out UGIB → proceed to colonoscopy See source → intervene as needed See nothing → CT angiography for large bleed Tagged RBC scan for smaller bleed Antiplatelet Pharmacology Aspirin Mechanism? Irreversibly inhibits COX-1 and COX-2 Clopidogrel/ticlopidine = P2Y12 (ADP receptor) blockers Mechanism? Inhibit platelet activation Abciximab/eptifibatide/tirofiban = GpIIbIIIa receptor blockers Mechanism? Inhibit platelet aggregation Ristocetin cofactor assay Issues with adhesion step → abnormal result Abnormal ristocetin cofactor assays: Von Willebrand disease Bernard Soulier disease Normal ristocetin cofactor assay: Glanzmann Thrombasthenia Von Willebrand disease effects on PTT? Increased Pathophys? vWF is a protecting group for Factor 8. Treatment of VWD? Desmopressin Mechanism? Increases release of vWF from Weibel-Palade bodies of endothelial cells Note: Desmopressin = ADH analog → so, it can cause AE of hyponatremia 2/2 SIADH HSV1 vs HSV2. Oral herpes → HSV1 Genital herpes → HSV2 Dx? PCR (most up-to-date) Tzanck smear (outdated, not very sensitive, nonspecific) → intranuclear inclusions Brain area affected by HSV encephalitis? Temporal lobes CSF findings in HSV encephalitis? RBCs******* Tx herpes encephalitis? Acyclovir AE? Crystal nephropathy Can’t see, can’t pee, can’t climb a tree. → reactive arthritis HLA? B27 Classic bug? Chlamydia Tx? steroids Need abx? Only if ongoing infection Can’t see, can’t pee, can’t hear a bee → Alport syndrome Inheritance? X-linked dominant Tx of NG & CT NG → treat empirically for both → ceftriaxone + azithro/doxy CT → azithro/doxy Hypovolemic Septic Neurogenic Cardiogenic CO low PCWP low SVR high*** CO high PCWP normal SVR low Tx? norepi CO low SVR low CO low PCWP high*** SVR high*** Tx anaphylactic shock? epinephrine Melanomas ABCDE A = asymmetry B = irregular borders C = color variation D = diameter > 6 mm E = evolving Dx? Full-thickness biopsy Excisional for small lesions Punch for larger lesions Most important prognostic factor → Breslow depth DM pharmacology Lactic acidosis → metformin Decreases hepatic gluconeogenesis → metformin Hold before CT w/ contrast → metformin Weight gain → sulfonylureas & TZDs (-glitizones) Diarrhea → acarbose & migliton Inhibits disaccharidases (can’t reabsorb disaccharides) Recurrent UTIs → SGLT-2 inhibitors Weight loss → GLP-1 agonists (e.g. liraglutide, exenatide) & DPP4 inhibitors (-gliptins) Contraindicated in pt with HF → TZDs PPAR-gamma receptor found in kidney → water retention Contraindication in pt with MTC → GLP-1 agonists Biggest risk of hypoglycemia? Sulfonylureas RF esophageal adenocarcinoma Barrett’s esophagus RF esophageal squamous cell carcinoma Smoking Drinking Achalasia Location esophageal adenocarcinoma? Lower 1/3 Location esophageal squamous cell carcinoma? Upper 2/3 MC US? Adenocarcinoma MC worldwide? Squamous cell carcinoma Presentation? Dysphagia to solids → dysphagia to liquids Dx? EGD Staging? CT scan or esophageal US Factor V Leiden Pathophys? Resistance to protein C Dx? Activated Protein C resistance assay Patient needs super large doses of heparin to record any changes in PTT → AT-III deficiency Recall that heparin is a AT-III activator 35 yo with a hypercoagulable disorder that does not correct with mixing studies. → antiphospholipid antibody disorder Anaphylaxis in a patient with a long history of Hemophilia A → Ab against factor 8 that cause type 1 HSR with transfusion Hx of hemophilia, diagnosed 5 years ago. Before you would give them factor 8 concentrate and PTT would normalize. Now they’re requirizing larger doses of factor 8 to normalize PTT. → inhibitor formation (antibodies against clotting factors) Skin necrosis with Warfarin → protein C/S deficiency Prothrombin G20210 mutation → overproduction of factor II Rash in dermatomal distribution → VZV infection Contraindications to VZV vaccination? Pregnant woman Kid < 1 year Severe immunosuppression (e.g. HIV with CD4 < 200) Tx? Acyclovir If resistant, foscarnet Tzanck smear findings? Intranuclear inclusions Shingles vaccination guidelines? Adults over 60 #1 cause of ESRD in the US → DM nephropathy Histology? Kimmelsteil-Wilson nodules #2 cause of ESRD in the US → hypertensive nephropathy Pt with BP 240/150. How fast should you lower BP? 25% in first 24 hrs Drugs for hypertensive emergencies? Nicardipine Clevidipine Nitroprusside AE? Cyanide poisoning Tx? Amyl nitrate + thiosulfate OR hydroxocobalamin Labelol Renal protective medications in patients with DKD or hypertensive nephropathy? ACE-I Anemia + Cranial Nerve deficits + Thick bones + Carbonic Anhydrase 2 deficiency + Increased TRAP + Increased Alkaline Phosphatase. → osteopetrosis Pathophys? Carbonic anhydrase is defective → osteoclasts cannot produce acid to resorb bone Tx? IFN-gamma Osteoclasts are a specialized macrophage IFN-gamma is an activator of macrophages Clinical diagnostic criteria for Chronic Bronchitis Diagnostic criteria? 2 years 3 months/year of chronic cough PFT findings FEV1 low FEV1/FVC ratio low RV high TLC high Which PFT market can differentiate CB from emphysema? DLCO DLCO normal → CB DLCO low → emphysema ****** Tx acute exacerbation? Abx + bronchodilators + corticosteroids (“ABCs”) Prevention? Stop smoking! Afib #1 RF? Mitral stenosis #1 RF MS? Rheumatic fever #1 RF CAD and AAA: smoking #1 RF stroke and aortic dissection: HTN MC arrhythmia in hyperthyroidism → Afib MC site of ectopic foci in Afib → pulmonary veins EKG findings? “Irregularly irregular” + no P waves Location of emboli formation? LA appendage Who should be cardioverted back to sinus rhythm? New onset (<48 hrs) Afib Anticoagulated for 3 weeks + TEE negative for clot Afib that’s refractory to medical therapy Afib & HDUS Q on T phenomenon? Depolarization during T wave (repolarization) can cause QT prolongation → Torsades → death Prevention? SYNCHRONIZED cardioversion Tx? Rate control Beta blockers ND-CCB (e.g. verapamil, diltiazem) Rhythmic control Amiodarone Reducing stroke risk in Afib? Anticoagulation for CHA2DS2VASc score >= 2 Anticoagulation options Valvular cause (e.g. MS) → warfarin Any other cause → warfarin or NOAC (apixiban) Reversal of AC Warfarin → Vit K, four-factor PCC Heparin → protamine sulfate Dabigatran → idarucizumab Crusty, scaly, ulcerating lesion with heaped up borders → squamous cell carcinoma Classic location? Below Lower lip Precursor lesion? Actinic keratosis What if it arises in a scar or chronic wound? Marjolin ulcer Hypothermia + hypercapnia + non pitting edema + hyponatremia + HR of 35 + hypotension in a patient with a history of papillary thyroid cancer → myxedema coma Tx? Levothyroxine + steroids Lab findings? TSH high T3/T4 low LDL high Acute onset “dermatologic” breakout in a patient with a recent history of weight loss and epigastric pain. → Leser–Trélat sign associated with visceral malignancy pancreatic cancer Lymph node associations Supraclavicular → Virchow’s node Periumbilical → Sister Mary Joseph What are mets to the ovaries called? Kruckenberg tumor Classic bug associated with gastric cancer? H. pylori (MALToma) Classic histological finding in the diffuse type of gastric cancer? Signet ring cells RBCs without central pallor + elevated MCHC + anemia. → hereditary spherocytosis Inheritance? AD Pathophys? Deficiency of spectrin, ankyrin, or band 3.2 Intravascular or extravascular hemolysis? Extravascular (RBCs bound by IgG, attacked by splenic macrophages) Dx? Osmotic fragility test Eosin-5-maleimide Acidified glycerol lysis test Tx? Splenectomy Post-splenectomy preventative care? Strep pneumo Hinflue vaccine Neisseria Septic shock Hemodynamic parameters CO high SVR low PCWP normal MvO2 high Tx? IVF + norepi + broad-spectrum abx (cover MRSA + Pseudomonas) E.g. vanc + pip-tazo E.g
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Immune System Study Guide Function of the Immune System Main Function: The immune system protects the body from harmful invaders (pathogens like bacteria, viruses, fungi, etc.) and detects and eliminates abnormal cells.Detects and destroys foreign invaders . Yngv Memory: The immune system has the ability to "remember" past infections, allowing it to respond more quickly to the same pathogen if encountered again.Maintains a memory of past infections to mount a quicker response if the same pathogen attacks again. Types of Immunity Innate Immunity: The immune system you're born with; provides a quick response to any pathogen. First line of defense: Skin and mucus act as physical barriers. Macrophages: Large white blood cells that "eat" pathogens and activate other immune cells. Histamine & Inflammation: Histamine triggers inflammation to fight infection (redness, heat, swelling, pain). Adaptive Immunity: Develops over time and strengthens with repeated exposure to pathogens. B-cells: Produce antibodies that specifically target pathogens. T-cells: Help destroy infected cells or coordinate the immune response. Memory Cells: "Remember" past infections for faster responses in the future. Innate immunity is something you're born with and provides a quick response to any pathogen. Adaptive immunity develops over time, adapting to new threats. It includes things like antibodies and memory cells. Signs of Inflammation Redness (rubor): Increased blood flow to the affected area. Heat (calor): Blood flow increases temperature at the site. Swelling (tumor): Fluid accumulation and immune cells moving to the area. Pain (dolor): Due to chemicals irritating nerve endings. Loss of Function (functio laesa): Temporary loss of function in the inflamed area. Bacteria vs. Viruses feature bacteria viruses size bigger smaller Can live without a host? yes no Good or bad Some are helpful Always harmful treatment Antibiotics kill them No antibiotics, only vaccines or immune system fights them examples Strep throat Flu, COVID-19 Antibiotic Resistance Occurs when bacteria evolve to resist antibiotics. Reasons for Resistance: Overuse or misuse of antibiotics. Using antibiotics for viral infections. Self-medicating without proper diagnosis. Vaccines What Are They?: Biological preparations that provide immunity against specific diseases. How Do They Work?: Contain weakened or inactivated parts of a pathogen to stimulate an immune response. Importance: Vaccines teach the immune system to recognize pathogens and fight them effectively in the future. They also contribute to herd immunity. Reproductive System Study Guide Male Reproductive System Testes: Produce sperm and the hormone testosterone. Epididymis: Stores sperm until they mature. Vas Deferens: Transports sperm from the testes to the urethra. Prostate Gland & Seminal Vesicles: Produce fluids that nourish and transport sperm. Penis: Delivers sperm into the female reproductive tract during ejaculation. Female Reproductive System Ovaries: Produce eggs (ova) and hormones like estrogen and progesterone. Fallopian Tubes: Transport eggs from the ovaries to the uterus; fertilization typically occurs here. Uterus: Where a fertilized egg implants and develops during pregnancy. Cervix: The lower part of the uterus that connects it to the vagina. Vagina: The passage that receives sperm and also serves as the birth canal. Conception and Pregnancy Conception: Occurs when sperm fertilizes an egg in the fallopian tube, forming a zygote, which then implants in the uterus. Pregnancy: The zygote develops into an embryo and then a fetus in three trimesters: First Trimester (Weeks 1-12): Organ development begins; the heart starts to beat. Second Trimester (Weeks 13-26): Rapid growth; organs mature and gender can be determined. Third Trimester (Weeks 27-Birth): The fetus continues to grow; organs mature, especially the lungs. Factors Affecting Baby Development Environmental factors: Exposure to toxins, pollutants, drugs, or infections. Nutrition: Essential nutrients are crucial for healthy fetal development. Health conditions: Chronic conditions like diabetes or hypertension can affect pregnancy. Types of Contraception Barrier Methods: Condoms (Male & Female): Prevent sperm from reaching the egg and protect against STDs. Pros: Easy to use, no side effects, protects against STDs. Cons: Must be used correctly every time; can break or slip off. Diaphragm with Spermicide: A barrier placed in the vagina to cover the cervix. Pros: Non-hormonal, on-demand use. Cons: Requires fitting, not effective without spermicide. Hormonal Methods: Birth Control Pills: Prevent ovulation through hormones like estrogen and progesterone. Pros: Highly effective, can regulate periods, reduces acne. Cons: Must be taken daily, side effects like nausea or headaches. Patch: Worn on the skin to release hormones. Pros: Easy to use, weekly change. Cons: Visible, may cause skin irritation. Implant: A small device placed under the skin to release hormones. Pros: Long-lasting (up to 3 years), effective. Cons: Requires professional insertion, can cause irregular bleeding. IUD (Intrauterine Device): A device inserted into the uterus to prevent fertilization. Pros: Long-lasting (5-10 years), effective. Cons: Requires professional insertion, may cause cramping. Permanent Methods: Vasectomy (Male): Cutting and sealing the vas deferens to prevent sperm from reaching the urethra. Tubal Ligation (Female): Cutting or sealing the fallopian tubes to prevent eggs from reaching the uterus. Pros: Permanent, highly effective. Cons: Surgical procedures, irreversible, not suitable for those wanting future children. Emergency Contraception: Morning-After Pill: Taken after unprotected sex to prevent pregnancy. Pros: Available over-the-counter, effective within 72 hours. Cons: Not for regular use, may cause side effects. Copper IUD: Can be inserted up to 5 days after unprotected sex to prevent pregnancy. Key Takeaways Immune System: It provides a defense against infections, relying on both innate (immediate) and adaptive (long-term) immunity, with important components like macrophages and memory cells. Vaccines are essential in helping the immune system recognize pathogens and prevent diseases. Reproductive System: Male and female systems work together to ensure conception and pregnancy, with critical stages of fetal development occurring in the three trimesters. Environmental factors and health conditions can impact pregnancy. Contraception Methods: There are various types, each with its pros and cons, including barrier methods, hormonal methods, and permanent methods. Choosing the right method depends on individual needs, effectiveness, and side effects. Histamine & Inflammation: Histamine release can cause redness, warmth, and swelling as part of the body's inflammatory response to infection or injury. Vaccines & Herd Immunity: Vaccines are critical in preventing the spread of infectious diseases by "teaching" the immune system to recognize and fight specific pathogens. Herd immunity occurs when a large portion of a population is vaccinated, making it harder for diseases to spread. Components of the Immune System: Defense against pathogens: The immune system helps protect the body from harmful invaders like bacteria, viruses, fungi, and parasites. Recognition of abnormal cells: It identifies and eliminates cells that are infected or cancerous Key Defense Lines: First Line of Defense: Skin & mucus trap and kill germs. Second Line of Defense: Inflammation and macrophages (eat germs). Third Line of Defense: T-cells destroy infected cells, B-cells make antibodies to target germs
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The ovaries
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