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Human Anatomy and Physiology Third Edition Chapter 1 Introduction to Anatomy and Physiology Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Characteristics of Living Organisms (1 of 2) Living Organisms share distinct properties •Cellular Composition—Cells are the smallest units that carry out the functions of life •Metabolism—Living organisms carry out chemical processes collectively called metabolism –“Building” processes are known as Anabolism –“Breaking down” processes are known as Catabolism •Growth—An increase in the size and/or number of cells Loading… Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Characteristics of Living Organisms (2 of 2) Living Organisms share distinct properties (continued) •Excretion—Elimination of potentially harmful waste products created by metabolic processes •Responsiveness or Irritability—Organisms sense and react to changes or stimuli in their environment •Movement—Organisms or individual cells of an organism move •Reproduction—Production of new cells during growth or repair or reproduction of new organisms Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Levels of Structural Organization and Body Systems (1 of 7) The body is constructed of a series of progressively larger “building blocks” known as the Structural Levels of Organization •Chemical Level—This is the smallest level; Chemicals range from tiny atoms to complex molecules •Cellular Level—Groups of many different types of molecules combine in specific ways to form cellular structures •Tissue Level—Two or more cell types and material outside them, called extracellular matrix, combine to perform a common function Loading… Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Levels of Structural Organization and Body Systems (2 of 7) Structural Levels of Organization (continued) •Organ Level—Two or more tissue types combine to form an organ with a recognizable shape that performs a specialized task •Organ System Level—Two or more organs that together carry out a broad function in the body –The human body has 11 organ systems •Organism Level—The organ systems function together to make up the working human body—an organism Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Levels of Structural Organization and Body Systems (3 of 7) Figure 1.5 Six structural levels of organization of the human body. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Levels of Structural Organization and Body Systems (4 of 7) Figure 1.6 The 11 organ systems of the human body Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Levels of Structural Organization and Body Systems (5 of 7) Figure 1.6 The 11 organ systems of the human body Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Levels of Structural Organization and Body Systems (6 of 7) Figure 1.6 The 11 organ systems of the human body Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Levels of Structural Organization and Body Systems (7 of 7) Figure 1.6 The 11 organ systems of the human body Loading… Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Types of Anatomy and Physiology (1 of 2) Study of Anatomy can be approached in several ways •Systemic Anatomy—Examines individual organ systems •Regional Anatomy—Examines the body in regions, such as the head and neck •Surface Anatomy—Examines surface markings •Gross Anatomy—Examines structures that can be seen with the unaided eye •Microscopic Anatomy—Examines cells (Cytology) and tissues (Histology) with the use of a microscope Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.2 Types of Anatomy and Physiology (2 of 2) Study of Physiology includes numerous subfields •Physiology subfields are classified by organ or organ systems, such as neurophysiology and cardiophysiology •Physiologists can also study other structural levels of organization of the body such as chemical, cellular, and tissue levels Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Word Parts •The language of science is built on Word Roots—core components of words with specific meanings •Word roots are combined with Prefixes and Suffixes to yield scientific terms •For example, combine the following: –Prefix an- (means without) –Word root encephala- (means brain) –Suffix -ic (means condition of) •“Anencephalic” is the condition of lacking a part of the brain Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 The Anatomical Position and Directional Terms (1 of 4) Anatomical Position—Common frame of reference from which all body parts and regions are described regardless of position –Body is standing upright –Feet are shoulder width apart –Upper limbs at the sides of trunk –Head and palms facing forward Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 The Anatomical Position and Directional Terms (2 of 4) Directional Terms—Describe the relative locations of body parts and markings to ensure accurate communication among scientists and healthcare professionals •Anterior/Posterior—Anterior refers to the front and posterior refers to the back; Can refer to body as a whole or to a body part •Superior/Inferior—Superior, or cranial, means towards the head and inferior, or caudal, means towards the tail; Used to refer to positions on head, neck, and trunk only Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 The Anatomical Position and Directional Terms (3 of 4) Directional Terms (continued) •Proximal/Distal—Proximal means closer to the point of origin and distal means further from the point of origin; Used to refer to positions on the limbs only •Medial/Lateral—Medial refers to a position closer to the middle line of the body, called the midline, and lateral refers to a position farther away from the midline •Superficial/Deep—Superficial refers to structures closer to the surface of the body and deep refers to structures farther below Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 The Anatomical Position and Directional Terms (4 of 4) Figure 1.7 Directional terms. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Medical Errors •Most medical errors occur when a patient is dispensed the wrong type or dose of medication •Occasionally, they involve surgery and are known as “wrong site” or “wrong body” procedures when the surgeon operates on the wrong part of the body or even the wrong patient •Precise communication with appropriate use of anatomical terminology is critical to prevent medical errors Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Regional Terms (1 of 7) Regional Terms—The body can be divided into two broad regions: Axial (head, neck, and trunk); and Appendicular (upper and lower limbs or appendages) •Each broad region can be divided into several smaller Regions •Regions may be named as nouns, such as the upper arm or brachium, or as adjective with the addition of a suffix such as -al, which is paired with the word “region” to give us the term brachial region Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Regional Terms (2 of 7) Figure 1.8 Regions of the body. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Regional Terms (3 of 7) Figure 1.8 Regions of the body. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Regional Terms (4 of 7) Table 1.1 Regional Terms Region of the Trunk Pertaining To: Abdominal The abdomen Cervical The neck Gluteal The buttocks Inguinal The groin Lumbar The lower back Pelvic The pelvis Pubic The pubis Sacral The sacrum Sternal The sternum Thoracic The chest Vertebral The spinal column Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Regional Terms (5 of 7) Table 1.1 Regional Terms Region of the Head and Face Pertaining To: Buccal The cheek Cranial The skull Cephalic The head Frontal The forehead Mental The chin Nasal The nose Occipital The back of the head Ocular The eye Oral The mouth Otic The ear Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Regional Terms (6 of 7) Table 1.1 Regional Terms Region of the Upper Limb Pertaining To: Acromial The point of the shoulder Antebrachial The forearm Antecubital The anterior surface of the elbow Axillary The armpit Brachial The arm Carpal The wrist Digital The fingers (or toes) Manual The hand Metacarpal The metacarpals (bones of the hand) Palmar The palm Pollex The thumb Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Regional Terms (7 of 7) Table 1.1 Regional Terms Region of the Lower Limb Pertaining To: Coxal The hip Crural The anterior surface of the leg Femoral The thigh Hallux The great toe Metatarsal The metatarsals (bones of the foot) Patellar The anterior surface of the knee Pedal The foot Plantar The sole of the foot Popliteal The posterior surface of the knee Sural The posterior surface of the leg Tarsal The ankle Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Concept Boost: Putting Anatomical Terms Together (1 of 2) 1.Name the Region—Cervical region 2.Add Descriptive Directional Terms— On anterior side, Lateral to midline; Begins inferior to mental region; Ends superior to thoracic region 3.Describe Depth of Incision—Deep to skin and muscle; Superficial to underlying larynx 4.Put It All Together—Incision on anterior cervical region lateral to midline; Extended vertically 1 centimeter inferior to mental region to 2 centimeters superior to thoracic region; Deep to skin and muscle, but superficial to larynx Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Concept Boost: Putting Anatomical Terms Together (2 of 2) 1.Name the Region—Left Crural 2.Add Descriptive Directional Terms— On anterior and medial side; Proximal to tarsal region and distal to patellar region 3.Describe Depth of Incision—Deep to skin and muscle but superficial to bone 4.Put It All Together—Wound on left anteromedial crural region, 10 centimeters proximal to tarsal region and 6 centimeters distal to patellar region; Pellet is lodged deep to skin and muscle but superficial to bone Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Concept Boost Mini Lecture: Putting Anatomical Terms Together Use the link below to view A D A compliant video: Concept Boost Mini Lecture: Putting Anatomical Terms Together https://mediaplayer.pearsoncmg.com/assets/_video.true/bc_amerman_hap_3_concept-boost_ch1 Loading… Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Planes of Section (1 of 4) Planes of Section—Divide a body or body part for examination •Sagittal Plane—Divides body into right and left sections –Midsagittal Plane: Also called a Median Plane; Sections are equal –Parasagittal Plane: Sections are unequal Figure 1.9a Sagittal plane. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Planes of Section (2 of 4) Planes of Section (continued) •Frontal Plane—Also called a Coronal Plane; Divides body into anterior and posterior sections Figure 1.9b Frontal plane. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Planes of Section (3 of 4) Planes of Section (continued) •Transverse Plane— Also called a Horizontal Plane or Cross Section; Divides body into superior and inferior sections or proximal and distal sections •Oblique Plane—Used less frequently; Taken at an angle Figure 1.9c Transverse planes. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.3 Planes of Section (4 of 4) Study Boost: How to Learn Anatomical Terms •Flashcards are popular because research shows that they work –Make customized flashcards with Practice Anatomy Lab™ Flashcards in the Study Area of Mastering® A&P –Make handwritten flashcards •Don’t forget to “Bring It Back” by quizzing yourself and “Mix It Up” by randomizing the order Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 The Posterior Body Cavity Cavity—Any space within the body; Protects internal organs and allows them to move Posterior Body Cavity— Located on posterior side of body •Cranial Cavity—Within the skull; Includes the brain •Spinal Cavity—Within the vertebral column; Includes the spinal cord •Both cavities are filled with Cerebrospinal Fluid, which bathes both organs Figure 1.10a Posterior body cavity, lateral view. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 The Anterior Body Cavity (1 of 8) Anterior Body Cavity—Has two main divisions separated by the muscular diaphragm •Thoracic Cavity is superior to the diaphragm •Abdominopelvic Cavity is inferior to the diaphragm •Smaller cavities exist within the thoracic and abdominopelvic cavities formed by sheets of tissue termed Serous Membranes Figure 1.10b Anterior body cavity, anterior view. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 The Anterior Body Cavity (2 of 8) Anterior Body Cavity (continued) •Thoracic Cavity –Pleural Cavities—Surround left and right lungs –Mediastinum—Between pleural cavities; Houses heart, great vessels, trachea (windpipe), and esophagus; Not within serous membrane –Pericardial Cavity—Within mediastinum; Within serous membrane that surrounds heart Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 The Anterior Body Cavity (3 of 8) Anterior Body Cavity (continued) •Abdominopelvic Cavity—Subdivided into superior Abdominal Cavity (diaphragm to bony pelvis) and inferior Pelvic Cavity (within bony pelvis) •Contains organs from digestive, lymphatic, urinary, and reproductive systems •Peritoneal Cavity—Abdominal subcavity found within serous membranes Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 The Anterior Body Cavity (4 of 8) Abdominopelvic Cavity can be divided into segments by drawing imaginary lines through its surface •One system divides the cavity into four Quadrants –Right and left upper quadrants (R U Q and L U Q); Right and left lower quadrants (R L Q and L L Q) •A second system divides the cavity into nine Regions –Right and left hypochondriac regions, Right and left lumbar regions; Right and left iliac regions; Epigastric region; Umbilical region; Hypogastric region Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 The Anterior Body Cavity (5 of 8) Figure 1.11 The four quadrants and nine regions of the abdominopelvic cavity. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 Abdominal Pain •Abdominal pain is a common reason for people to seek health care, but the number of structures in the abdominopelvic cavity make diagnoses difficult •The four-quadrant system helps to narrow down potential diagnoses •For example, R L Q pain may be from the appendix, ovaries in female, the first part of the large intestine, or the last portion of the small intestine Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 The Anterior Body Cavity (6 of 8) Serous Membranes—Thin sheets of tissue that fold over to form continuous double-layered structures filled with Serous Fluid to lubricate organs in the cavity –Visceral Layer—Contacts the organ –Parietal Layer—Attaches to surrounding structures Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 The Anterior Body Cavity (7 of 8) Serous Membranes (continued) •Pleural Membranes—Surround the lungs; Includes parietal and visceral pleura •Pericardial Membranes—Surround the heart; Includes parietal and visceral pericardium •Peritoneal Membranes—Surround some abdominal organs (Intraperitoneal); Includes parietal and visceral peritoneum •Organs behind the parietal peritoneum are Retroperitoneal Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 The Anterior Body Cavity (8 of 8) Figure 1.13 The serous membranes of the anterior body cavities. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 Medical Imaging (1 of 2) •Used to look inside patients without surgery; Different forms of radiation form images of internal structures often along specific planes •X-Ray uses ionizing radiation; Chest image is shown (top) •Computed Tomography Scan (C T) uses ionizing radiation; 3-D image is computer generated from data; Transverse section of abdominopelvic and peritoneal cavities is shown (bottom) Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.4 Medical Imaging (2 of 2) •Magnetic Resonance Imaging (M R I) involves the body being placed within a magnetic field; 3-D image is computer generated from data; Transverse section of the abdominopelvic cavity is shown Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Core Principles in Anatomy and Physiology Core Principles—Set of basic concepts of anatomy and physiology that are revisited repeatedly in the text; They are related to maintaining the body’s internal environment •Feedback Loops •Relationship of Structure and Function •Gradients •Cell-Cell Communication Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Overall Theme: Physiological Processes Operate to Maintain the Body’s Homeostasis •Homeostasis—The condition in which the body develops and maintains a relatively stable internal environment –Homeostatic Imbalances—Disturbances in homeostasis can lead to disease or death if uncorrected –Regulated Variables—Variables in the internal environment, such as temperature, blood sugar, and many others, are controlled to stay close to a particular normal value –Controlled Variables—Variables that are manipulated to maintain the regulated variables, such as the process that increases blood sugar from stored carbohydrates Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Feedback Loops Are a Key Mechanism Used to Maintain Homeostasis (1 of 8) Feedback Loops—A change in a regulated variable causes effects that feed back and in turn affect that same variable •Made up of a series of events that lead to an output •As the loops continue, this output then influences the events of the loops themselves •Negative Feedback Loops—Oppose the initial change and reduce the output •Positive Feedback Loops—Reinforce the initial change and increase the output Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Feedback Loops Are a Key Mechanism Used to Maintain Homeostasis (2 of 8) Negative Feedback Loops—Promote stability; Negating any stimulus that moves a variable away from homeostasis •Each variable has a Set Point that includes a Normal Range around that set point •The range differs for individual variables Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Feedback Loops Are a Key Mechanism Used to Maintain Homeostasis (3 of 8) Steps of a Negative Feedback Loop 1.Stimulus—Information that a regulated variable is outside the normal range 2.Receptor or Sensor—Cellular structure that registers the stimulus 3.Control Center—Stimulus is sent to the control center (brain or gland) by the nervous or endocrine systems 4.Effector—The cells or organ that will react 5.Responses—Effector causes the response that will return the variable to the normal range Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Feedback Loops Are a Key Mechanism Used to Maintain Homeostasis (4 of 8) Figure 1.14 Control of room temperature by a negative feedback loop. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Feedback Loops Are a Key Mechanism Used to Maintain Homeostasis (5 of 8) Figure 1.15 Control of body temperature by a negative feedback loop. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Feedback Loops Are a Key Mechanism Used to Maintain Homeostasis (6 of 8) Study Boost: Keeping Track of the Body’s Feedback Loops •Feedback loops occur in all body systems so there are many to remember •As you learn new feedback loops, add them to the Feedback Loops Master List page at the front of the Active-Learning Workbook •Use the list to quiz yourself “Bring It Back,” review feedback loops from other chapters “Space It Out,” and have a friend quiz you from the list in a random order “Mix It Up” Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Feedback Loops Are a Key Mechanism Used to Maintain Homeostasis (7 of 8) Positive Feedback Loops—Less common than negative feedback loops; Increases the response to a stimulus; Reinforces the initial stimulus •Will eventually shut off in response to an external stimulus or some outside event that is not part of the positive feedback loop •Positive feedback loops are often found within a negative feedback loop to produce a quicker response Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Feedback Loops Are a Key Mechanism Used to Maintain Homeostasis (8 of 8) Figure 1.16 Control of blood clotting by a positive feedback loop. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Common Misconceptions about Homeostasis (1 of 2) •Misconception 1: Negative feedback is bad for the body; Positive feedback is good –Under normal circumstances, both types of feedback loops promote homeostasis •Misconception 2: Maintaining homeostasis means the body’s internal environment is static or unchanging –Maintenance of normal ranges does not mean the internal environment is unchanging; Changes are normal and are occurring constantly Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Common Misconceptions about Homeostasis (2 of 2) •Misconception 3: Regulatory mechanisms and feedback loops are either “on” or “off,” like a switch –The internal environment is dynamic so feedback loops always exhibit some degree of activity •Misconception 4: Any physiological variable can be controlled –Variables can only be controlled through feedback loops if receptors exist to detect changes in the set point Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 BioFlix: Homeostasis Use the link below to view A D A compliant video: BioFlix: Homeostasis https://mediaplayer.pearsoncmg.com/assets/loMS4qosEmL53haP3z1Z_eWMupIkyIFv Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Childbirth, Pitocin, and Positive Feedback Loops •Childbirth begins when a woman goes into labor, which occurs by a positive feedback loop •Baby’s head stretches the cervix (stimulus); Data from nerves in the cervix (receptors) are sent to the brain (control center); Uterus (effector) produces hormone oxytocin which stimulates uterine contractions (response); This continues and is amplified until the baby is born, which stops the feedback loop •Pitocin is a synthetic version of oxytocin that is used when labor needs to be artificially started, or induced Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Structure and Function are Related at All Levels of Organization Principle of Complementarity of Structure and Function •The form of a structure is such that it best suits its function; Applies to all levels of organization Figure 1.17 The relationship between structure and function. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Gradients Drive Many Physiological Processes Gradients are present any time more of something exists in one area than another and the two areas are connected •Gradients drive many of our physiological processes Figure 1.18 Examples of gradients. Copyright © 2025, 2019, 2016 Pearson Education, Inc. All Rights Reserved 1.5 Cell-Cell Communication is Required to Coordinate Body Functions •Cells communicate with each other to maintain homeostasis •Electrical Signals are transmitted between neighboring cells •Chemical Messengers released from cells may work on neighboring cells or move to other cells through body fluids Figure 1.19 Communication between a nerve cell and a muscle cell.