PC101

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homeostasis, osmosis etc

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homeostasis
the ability of an organism to maintain constant internal conditions despite changes in the external environment

all levers of organisation contribute to homeostasis
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steady state
another term for homeostasis
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Things to keep stable
* body temp
* blood pH
* blood glucose levels
* amount of wastes in blood
* blood pressure
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3 step process in maintaining stable body conditions
* change must be detected somehow
* solution must be developed
* adjustments must be made
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receptors
step 1 in maintaining stable body conditions
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what occurs within receptors
cells receive messages about a change which is known as the stimulus
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examples of receptors
sense organs:

* eyes
* ears
* nose
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chemoreceptors
detect chemicals such as glucose levels
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baroreceptors
detect pressure such as full bladder
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control centre
involved in step 2 of maintaining stable body conditions
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what occurs within the control centre
received info from receptors, then sends messages back out to fix the problem
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effectors
step 3 in maintaining stable body conditions
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what occurs within effectors
cells, tissues and organs follow instructions from the control centre and make changes to produce a response
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negative feedback loop
reduces or opposes the intensity of the stimulus
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set point
the physiological value around which the normal range fluctuates
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normal range
the restricted set of values that is optimally stable and healthful
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what does homeostasis aim to reach
homeostasis aims to keep the body at the set point
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positive feedback
the response increases the stimulus rapidly until end point is reached
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components of cell membrane
has 2 layers of lipids

has a phospholipid inlayer
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structure of lipids
polar heads

non polar and hydrophobic tails
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function of phospholipid bilayer
allows water inside and outside of the cell
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membrane proteins
peripheral and integral proteins
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peripheral proteins
do not go all the way through the membrane, acts likes assistants to integral proteins
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integral proteins
goes all the way through the membrane
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3 types of integral proteins
transporter, cell surface identity maker, cell surface receptor
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transporter cell surface
moves things in and out of the cell
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cell surface identity maker
cell recognition eg. antigen
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cell surface receptor
brings a message into the cell
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what can cross the phospholipid bilayer
non-polar, hydrophobic molecules that have no charge
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polar
electrons aren’t shared evenly
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how do non-polar hydrophobic molecules cross through the phospholipid bilayer
dissolves in membrane and goes through

smaller molecules cross more quickly
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what cannot cross the phospholipid bilayer
polar hydrophilic molecules mostly cannot cross

water and ethanol are polar but small - some get through

large polar molecules eg. glucose

charged molecules
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2 methods of transport across the cell
active transport and passive transport
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active transport
the movement of substances across the membrane using energy, usually against concentration gradient
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passive transport
movement of substances across the membrane without the use of cellular energy, usually with the concentration gradient
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concentration gradient
occurs when a substance is more concentrated in one area than another
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diffusion
movement from high to low concentration
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passive diffusion
does not require energy
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movement of ions or smaller polar molecules
cannot pass through the phospholipid bilayer but there are channels made of protein

moves along the concentrated gradient through facilitated diffusion
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active transport requirements and method : primary
against concentration gradient and requires energy and special protein channels
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active transport : secondary
uses the electrochemical gradient of an ion to move something else against its gradient
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antiporter
membrane protein that transports two molecules at the same time in the opposite direction
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symporters
proteins that transports two molecules across a membrane in the same direction
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where do large molecules move in and out of the cell
through vesicles and vacuoles
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endocytosis
moves large molecules to the inside of a cell
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exocytosis
moves large molecules to the outside of a cell
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osmosis
diffusion of water through a semi-permeable membrane

from a high concentration to a low concentration
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hypertonic
more solutes and less water in a solution
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hypotonic
less solute and more water in a solution
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isotonic
equal in solute and water in a solution
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passive transport
movement of substances across the membrane without the use of cellular energy, with the concentration gradient
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metabolism
sum of all biochemical reactions occurring in the cells
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2 types of metabolism
anabolic and catabolic
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anabolic reactions
building/making molecules
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catabolic reactions
breaking down molecules/breaking bonds
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what do biochem reactions require
most biochem reactions need enzymes to increase the speed of the reaction to sustain life
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methods to make particles collide
* make particles smaller
* add heat energy to increase movement causing more collisions
* alter concentration/pressure
* using catalysts
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enzymes
proteins that act as a catalyst to increase the rate of reactions
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active site
area on the enzyme where the substrate attach
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size of enzymes and active site
enzymes are usually very large proteins and the active site is just a small region
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function of active site
males enzymes specific to particular substrates
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pathways
metabolic reactions occur in a series of these pathway reactions
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3 reasons cells need energy
chemical, mechanical and electrochemical
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energy for chemicals
to aid the building/rearranging/breaking apart of substances
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energy for mechanicals
to aid the movement of cell structure eg.cilia
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energy for electrochemical
to aid the movement of charged particles across membranes
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how do cells get energy (1)
breaking down high energy moles in food through metabolic pathways
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how do cells get energy (2)
law of conservation of energy
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how is ATP used
* energy in phosphate bonds
* bonds broken = energy released
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cellular respiration
glucose + oxygen - water + carbon dioxide + ATP

describing the metabolism of carbohydrates
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metabolism of carbohydrates
over 3 metabolic pathways:

* glycolysis
* citric acid cycle
* oxidative phosphorylation
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beta oxidation
a metabolic pathway where fatty acids are used to produce energy
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glycolysis
* series of chemical reaction
* occurs in cytoplasm
* does not need oxygen
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substrate and product of glycolysis
substrate = glucose

product = pyruvate
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ATP within glycolysis
uses 2 ATP and produces 4 ATP
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TCA/Citric acid/Krebs cycle
in the presence of oxygen

pyruvate is converted to Acetyl-CoA inside the mitochondria

Acetyl-CoA enters the cycle
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link reactions
where pyruvate is converted to Acetyl-CoA inside the mitochondria
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where does oxidative phosphorylation occur
occurs in the mitochondria
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2 parts of oxidative phosphorylation
electron transfer chain

chemiosmosis
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fermentation
following glycolysis, if oxygen is absent then pyruvate is converted into lactate - lactic acid
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how is ATP produced
By breaking down glucose metabolic pathways
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breakdown of glucose (step 1 in making ATP)
begins with glycolysis which can be aerobic or anaerobic
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what reaction is lactate produced in
anaerobic
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aerobic reaction of glycolysis (step 2 in making ATP)
both glycolysis and beta oxidation feed their products into the citric acid cycle which produces carbon dioxide
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where does hydrogen within oxidative phosphorylation come from (step 3 in making ATP)
glycolysis and citric acid cycle strip hydrogen from carbohydrates
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Final step in making ATP
Oxidative phosphorylation combines the hydrogen with oxygen to make water - this process provides the energy to run ATPase which produces ATP
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phosphorylation
adding phosphate
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coordinated processes/variables
body’s internal environment
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core principles
* feedback loops
* structure function
* cell-cell communication
* gradients
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potential energy
energy that is stored
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2 basic types of passive transport
diffusion and osmosis
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properties of water
water absorbs heat without changing significantly in temperature itself

water carries heat with it when it changes from a liquid to a gas

water cushions and protects the body’s structure

water as a lubricant between 2 adjacent surfaces
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yield of glycolysis
spent 2 ATP

produces 4 ATP

produced 2 NADH

splits glucose into 2-3 carbon pyruvate
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which pathways produce acetyl CoA
glycolysis and beta oxidation
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what are the metabolic cycles used for glucose metabolism
glycolysis, citric acid cycle, oxidative phosphorylation
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what pathway metabolises acetyl-CoA
citric acid cycle
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how does water move in regards to concentration gradient
water moves down the concentration gradient
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what causes cells to swell
hypotonic solutions
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what causes cells to shrink
hypertonic solutions
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what reaction produces the most ATP
oxidative phosphorylation