ANEMIA 4

A DISORDER THAT SHOWS A DEFECT IN DNA SYNTHESIS

A DISORDER THAT SHOWS A DEFECT IN DNA SYNTHESIS

MEGALOBLASTIC ANEMIA

MEGALOBLASTIC ANEMIA IS CAUSED BY?

VITAMIN B12 (COBALAMIN), FOLATE DEFICIENCY, PERNICIOUS ANEMIA

IN MEGALOBLASTIC ANEMIA, HEMOGLOBIN HEMATOCRIT AND RETICS COUNT ARE INCREASED OR DECREASED?

DECREASED

VITAMIN B12 DEFICIENCY IS ALSO KNOWN AS?

PERNICIOUS ANEMIA, ADDISON’S ANEMIA

WHAT ARE THE CLINICAL FINDINGS FOR VITAMIN B12 DEFICIENCY?

PERNICIOUS ANEMIA, ACHLORHYDRIA, WEAKNESS AND NUMBNESS, SORE TONGUE, GI DISORDER, CNS PROBLEMS

NON-MEGALOBLASTIC ANEMIA IS CAUSED BY?

LIVER DISEASE, ALCOHOLISM, BONE MARROW FAILURE

MEGALOBLASTIC OR NON-MEGALOBLASTIC. PRESENCE OF HYPERSEGMENTED NEUTROPHILS

MEGALOBLASTIC

MEGALOBLASTIC OR NON-MEGALOBLASTIC. ABSENCE OF HYPERSEGMENTED NEUTROPHILS

NON-MEGALOBLASTIC

SHAPE OF MACROCYTES IN MEGALOBLASTIC ANEMIA?

OVAL

SHAPE OF MACROCYTES IN NON MEGALOBLASTIC ANEMIA?

ROUND

MCV VALUE IN MEGALOBLASTIC ANEMIA

MORE THAN OR EQUAL TO 120 FL

MCV VALUE IN NON MEGALOBLASTIC ANEMIA

100-115 FL

WHAT ARE THE DISORDERS OF IRON METABOLISM AND HEME SYNTHESIS

IRON DEFICIENCY ANEMIA, SIDEROBLASTIC ANEMIA, ANEMIA OF CHRONIC DISEASE, IRON OVERLOAD

WHAT ARE THE DISORDERS OF BONE MARROW FAILURE?

APLASTIC ANEMIA

WHAT ARE THE DISORDERS OF DNA METABOLISM

MEGALOBLASTIC AND NON-MEGALOBLASTIC ANEMIA

ERYTHROPOIETIC DISORDER AND MAY BE ACQUIRED OR INHERITED

PURE RED CELL APLASIA

IF PRCA IS ACQUIRED, THIS MAY MEAN?

TRANSIENT ERYTHROBLASTOPENIA OF CHILDHOOD

IF PRCA IS INHERITED, THIS MAY MEAN?

DIAMOND-BLACKFAN ANEMIA

CHARACTERIZED BY APLASTIC ANEMIA, PHYSICAL ABNORMALITIES AND CANCER SUSCEPTIBILITY

FANCONI ANEMIA

CHARACTERIZED BY PANCYTOPENIA, MUCOCUTANEOUS ABNORMALITIES, AND BONE MARROW FAILURE

DYSKERATOSIS CONGENITA

CHARACTERIZED BY PANCREATIC INSUFFICIENCY, CYTOPENIA, SKELETAL ABNORMALITIES AND HEMATOLOGIC MALIGNANCIES

SHWACHMAN-BODIAN DIAMOND SYNDROME

WHAT CAN BE SEEN IN THE PERIPHERAL SMEAR OF SHWACHMAN-BODIAN DIAMOND SYNDROME

NEUTROPENIA AND PANCYTOPENIA

CLINICAL FEATURE OF FALCONI ANEMIA

LOW BIRTH WEIGHT, SKIN HYPERPIGMENTATION, SHORT STATURE

FATAL BONE MARROW FAILURE SYNDROME

APLASTIC ANEMIA

THIS SHOWS NO RESPONSE IN ERYTHROPOIETIN

APLASTIC ANEMIA

ACQUIRED APLASTIC ANEMIA IS HOW MANY PERCENT?

80-85%

INHERITED APLASTIC ANEMIA IS HOW MANY PERCENT?

15-20%

MOST COMMON FORM OF IRON OVERLOAD DISEASE

HEREDITARY HEMOCHROMATOSIS

HEREDITARY HEMOCHROMATOSIS IS CAUSED BY A MUTATION IN WHAT GENE?

HFE GENE

THIS GENE REGULATES THE AMOUNT OF IRON ABSORBED FROM FOOD

HFE GENE

WHAT IS THE TREATMENT FOR HEREDITARY HEMOCHROMATOSIS

PHLEBOTOMY

WHAT IS THE ENZYME AFFECTED IN CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP)—GUNTHER’S DISEASE

UROPORPHYRINOGEN III SYNTHASE DEFICIENCY

WHAT IS THE ENZYME AFFECTED IN ERYTHROPOIETIC PROTOPORPHYRIA (EPP)

FERROCHELATASE DEFICIENCY

WHAT IS THE ENZYME AFFECTED IN X-LINKED ERYTHROPOIETIC PROTOPORPHYRIA (XLEPP)

ALA-SYNTHASE (GAIN OF FUNCTION)

PORPHYRIA LITERALLY MEANS?

PURPLE

GROUP OF INHERITED DISORDERS CHARACTERIZED BY IMPAIRED PROTOPORPHYRIN PRODUCTION

PORPHYRIA

THIS INTERFERES WITH CONVERSION OF AMINOLEVULINIC ACID TO PORPHOBILINOGEN

LEAD

LEAD INTERFERES WITH INCORPORATION OF?

IRON AND PROTOPORPHYRIN

LEAD INHIBITS WHAT?

PYRIMIDINE 5’-NUCLEOTIDASE

THIS IS MOSTLY SEEN IN CHILDREN

LEAD POISONING (PLUMBISM)

THIS DISORDER BLOCK IN PROTOPORPHYRIN PATHWAY

SIDEROBLASTIC ANEMIA

IRON OVERLOAD IN BONE MARROW

SIDEROBLASTIC ANEMIA

ERYTHROBLASTS WITH IRON DEPOSITS SURROUNDING THE NUCLEUS

RING/RINGED SIDEROBLAST

IRON ACCUMULATION IN MATURE RBCS

SIDEROCYTE/PAPPENHEIMER BODY

STAIN FOR RINGED SIDEROBLAST

PRUSSIAN BLUE

STAIN FOR SIDEROCYTE/PAPPENHEIMER BODY

PERL’S PRUSSIAN BLUE, WRIGHT STAIN

THIS CAUSES THE INABILITY TO USE IRON

ANEMIA OF CHRONIC DISEASE

IN ANEMIA OF CHRONIC DISEASE THERE IS AN INCREASED LEVEL OF?

HEPCIDIN

THIS IS THE MEASURE OF IRON BOUND TO TRANSFERRIN

SERUM IRON

INDIRECTLY MEASURES TRANSFERRIN CONCENTRATION BY MEASURING ITS ABILITY TO BIND IRON

TOTAL IRON BINDING CAPACITY

PERCENTAGE OF IRON BINDING SITES OCCUPIED BY IRON

TRANSFERRIN SATURATION

REFLECTION OF BODY’S TISSUE IRON STORES

SERUM FERRITIN

MEASUREMENT OF PROTOPORPHYRIN WITHOUT IRON

FREE ERYTHROCYTE PROTOPORPHYRIN

IT IS THE MOST COMMON CAUSE OF ANEMIA IN THE US

IRON DEFICIENCY ANEMIA

INSUFFICIENT IRON FOR HEMOGLOBIN SYNTHESIS

IRON DEFICIENCY ANEMIA

IRON DEFICIENCY ANEMIA MAY ARISE FROM?

PREGNANCY, NORMAL GROWTH, MENSTRUATING WOMEN, BLOOD LOSS, INTRAVASCULAR HEMOLYSIS, GI DISORDER, PARASITIC INFECTION, MARCH HEMOGLOBINURIA

CLINICAL SYMPTOMS OF IRON DEFICIENCY ANEMIA

FATIGUE, DIZZINESS, PALLOR, PICA, ANGULAR CHEILOSIS, GLOSSITIS, KOILONYCHIA

WHAT IS THE NEW TERM FOR ANEMIA OF CHRONIC DISEASE

ANEMIA OF CHRONIC INFLAMMATION

SIDEROBLASTIC ANEMIA IS HEREDITARY IN?

X-LINKED AND AUTOSOMAL

IF SIDEROBLASTIC ANEMIA IS ACQUIRED IT CAN CAUSE WHAT DISEASE?

PRIMARY SIDEROBLASTIC ANEMIA AND SECONDARY SIDEROBLASTIC ANEMIA

IN LEAD POISONING, RBC PROTOPORPHYRIN IS INCREASED OR DECREASED?

INCREASED

RBC PROTOPORPHYRIN IS MEASURED USING A?

FREE ERYTHROCYTE PROTOPORPHYRIN

CLINICAL SYMPTOMS OF PORPHYRIA

PHOTOSENSITIVITY, FLUORESCENCE IN TEETH AND BONE, PSYCHOSIS, WINE-RED COLOR OF URINE

IN MEGALOBLASTIC ANEMIA, LACTATE DEHYDROGENASE IS INCREASED OR DECREASED?

INCREASED

THIS IS SIMILAR TO PERNICIOUS ANEMIA WITHOUT CNS INVOLVEMENT

FOLIC ACID DEFICIENCY