Rabies and CNS infections

microbiology

99% of human rabies is caused by

dog bites , scratches

how many serotypes does rabies have

one serotype

rabies virus multiplicates in

cytoplasm of cells

rabies vires is deactivated by

co2

5 stages of rabies progression

incupation period , prodromal phase , neurologic phase , coma , death

incubation period lasts how long

1-3 months ,

prodormal phase lasts

2-10 days

paralytic rabies occurs in

30% of paients most frequently in those infected with bat rabies virus

rabies diagnosis

history , physical examination , lab dx

rabies virus antigens are found in

negri bodies

pathogens ,ay access CNS by

bypassing bbb , using trans neuronal routes that pass bbb

infection of CNS parenchyma leads to

encephalitis

infection of csf and surrounding meninges lead to

meningitis

medically important fungi that infect CNS include

yeast , molds and dimorphic fungi

total time we need to soend on collection microscope and culturing should be

2 hours