EXAM 3: Hormonal and Reproductive Health

MOA - estrogen

• attached to estrogen receptors

• resolves manifestatiosn of menopause, allows for development and maintenance of female sex characteristics

indications - estrogen

menopause

hormonal imbalanced

gender-affirming care

contraindications - estrogen

history of DVT/PE, breast cancer

liver impairment

vaginal bleeding

client education - estrogen

can occur: edema, urticaria, HTN, gynecomastia, breast tenderness, NV, weight changes, dysmenorrhea

report clot risk/fluid balance: signs of DVT/PE and fluid retention

take missed dose ASAP

BBW - estrogen

increased risk of endometrial, breast, and ovarian cancer

increased risk of CV disease

MOA - progesterone therapy: medroxyprogesterone acetate

• induces changes to secretion s in the endometrial lining

• causes thickening of the uterine lining

indications - progesterone therapy: medroxyprogesterone acetate

• pain related to endometriosis

• dysfunctional uterine bleeding

• HRT

• endometrial carcinoma

contraindications - progesterone therapy: medroxyprogesterone acetate

meds - rifampin, phenobartitak, st. johns wort

client education - progesterone therapy: medroxyprogesterone acetate

can occur: breathrough bleeding, constipation, edema, headache, nausea

report thromboembolic disorder

perform self-breast exams

report leg or chest pain, edema, sudden vision changes, or SOB

BBW - progesterone therapy: medroxyprogesterone acetate

• increased risk of bone loss

  • not long term use

MOA - depo-testosterone

• binds to androgen receptors in body and converts testosterone to estradiol which allows binding to estrogen receptor

• increases male secondary sex characteristics

indications - depo-testosterone

• delayed puberty and hypogonadism

• gender-affirming care

• androgen-responsive breast cancers

contraindications - depo-testosterone

• lactation

• breast cancer

• prostate cancer

• OSA

• hx of MI or stroke within 6 months

client education - depo-testosterone

can occur: voice deepening, acne, facial hair, erectile dysfunction, breast growth

report signs of DVT/PE or suicidal thoughts

stop taking med if pegnancy

BBW - depo-testosterone

• BP increases resulting in major CV events with oral

• pulmonary oil microembolism may occur with IM testosterone