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Where ethylene glycol found?
In antifreeze
Is ethylene glycol harmful?
Not poisonous itself -> when broken down in liver by enzyme dehydrogenase
What is toxic?
Break down of product (oxalic acid)
What is the break down of product (oxalic acid)
Extremely toxic
What happens if they think someone has had ethylene glycol?
Patient given massive dose of ethanol (alcohol)
Why is the patient given ethanol?
Acts as competitive inhibitor for alcohol dehydrogenase -> Reduces production of oxalic acid -> Allows ethylene glycol to be excreted harmlessly