Experiment 4: Reductive Amination (Pt. 1)

Prelab and Procedure Questions

What is a heterocycle?

A cyclic ring structure that contains any element(s) outside of carbons and hydrogens

Which of the following molecules represent an unsubstituted amine?

A only

Which of the follow molecules represent an ammonium?

E

Referring to Figure 2 above, which statement is false?

Primary amines are more reactive than secondary amines

Predict the product of the following reaction

C

Predict the product of the following reaction

A

The synthesis of compound X requires 2 steps. The first step was accomplished in 80% yield and the second step in 80% yield. What is the overall yield of the 2-step synthesis?

64%

What has happened by the time a homogeneous mixture is formed from the two solids?

The imine is formed

What can happen if too much hexanes is used in the recrystallization?

the yield will be significantly lower

What is the most important piece of information that we can obtain from the IR spectrum at this step?

consumption of starting material can be distinguished by the disappearance of the C=O stretch at approximately 1700 cm-1

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Is *p*-toluidine or *o*-vanillin expected to have a lower Rf?

*p*-toluidine should have the lower Rf because it is the more polar molecule