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Atherosclerosis that develops in the femoral and popliteal arteries.
Peripheral Arterial Disease
Intermittent claudication
Peripheral Arterial Disease symptom
weak pulse, cool skin, pallor, hair loss
signs of chronic hypoxia
Chronic reduced blood flow in peripheral arteries
Signs of Peripheral Arterial Disease
Peripheral Meaning
away from the body
Sudden blockage of an artery
Acute Arterial Occlusion
completely blocks blood flow distal to the blockage. Sudden onset
Acute Arterial Occlusion
Emboli from heart, fat emboli from broken bones, air emboli
Common causes for acute arterial occlusion.
Pistol shot, pallor, polar, pulselessness, pain, paresthesia, paralysis
Manifestations of Acute Arterial Occlusion
atrophy or weakness of the medial layer or vessel wall causes a dilation of the artery in weak areas.
Causes aneursyms
increasing radius at the weaken spot increase tension.
Law of LaPlace
Accounts for 90-95% of HTN
>140 or >=90
Essential Hypertension
contraction of the heart; pumping
Systole
relaxation of the heart; filling.
Diastole
pulse pressure
systole-diastole
where are lipoproteins made
made in the small intestine and liver.
Triglycerides 55-65%
cholesterol 10%
protein 5-10%
main source of energy when fasting
Very low density lipoprotein (vldl)
Triglycerides 10%
cholesterol 50%
protein 25%
transports cholesterol out the blood
Low density lipoproteins (LDL)
Triglycerides 5%
cholesterol 20%
protein 50%
facilitates reverse transport of cholesterol, back to the liver to be secreted into the bile.
high density of lipoprotiens (HDL)
Elevated levels of LDL, and/or Triglycerides
Dyslipidema (Hyperlipidemia)
Treatments for Dyslipidemia
diet, exercise, medication as a last resort.
Xanthomas
cholesterol deposits caused by dyslipidemia
Dyslipidema can cause…
Acute arterial blockages can be caused by….
development of fibrous, fatty lesion in the intima of large and medium sized arteries
Atherosclerosis
most common cause of coronary heart disease
atherosclerosis is the most common cause of….
Thrombosis
bloodclots
narrowing of vessels, decreased blood flow
atherosclerosis
reduced blood flow
ischemia
atherosclerosis risk factors
family history, hyperlipidemia, increased age, male, smoking, obesity, diabetes, emerging role of inflammation.
Intermittent claudication
occurs when the patient is active; oxygen deficiency will happen in that area that will need more oxygen and won’t be able to get any because of reduced blood flow.
Biological factors for essential hypertension
genetics
lifestyle risk factors for essential hypertension.
weight, exercise
Criteria for HTN diagnonsis
2 separate readings of High bp
Secondary Hypertension
5-10% of HTN cases
develop as a result of another condition, like kidney disease. correction of underlying cause usually treats the bp.
Target organ damage of hypertension
heart: lv hypertrophy, angina (chest pain), MI, heart failure
TIA or stokes in brain.
chronic kidney disease
peripheral vascular disease
retinopathy
>180 &/or >120
risk of hypoperfusion, and ischemic injury
hypertensive crisis bp range
mental status changes, ICH, heart failure (HF), acute kidney injury (AKI), angina, acute myocardial infarction (AMI), CVA stroke.
hypertensive emergency signs and sytoms
BP quickly drops, decreasing CBF, HR increase → dizziness and & syncope (faints)
Orthostatic Hypotension
Orthostatic Hypotension cause
reduced blood volume
medications
aging
immobility, extended bed rest
ANS dysfunction
dilated, enlarged superficial veins
Varicose Veins
occurs due to impaired or blocked floe in deep veins, which creates increased pressure in superficial veins. common after 50, in obese person and women.
Varicose veins
Treatments for Varicose veins
support stockings, sclerosing agents, surgical repair
chronic venous insufficiency
caused by reflux/backflow through damaged veins.
chronic venous insufficiency
varicose veins, browning of the skin, eventual impaired nutrient delivery to tissues (necrosis, dermatitis, stasis ulcers - medial malleolus).
deep vein thromboses (DVTS) signs and symptoms
pain, swelling, deep muscle tenderness
DVTS risk factors.
blood stasis, vessel wall injury, increased coagulability.
Systolic BP = <20
Diastolic BP = <80
Normal BP
Systolic BP = 120-129
Diastolic BP = <80
Elevated BP
Systolic BP = 130-139
Diastolic BP = 80-89
Stage 1 Hypertension
Systolic BP = > 140
Diastolic BP = =>90
Stage 2 Hypertension
Heart disease due to impaired coronary blood flow
Coronary Artery Heart Disease
stable plague has what kind of growth
slow
unstable plague has what kind of growth
fast
leading cause of death in the US
coronary heart disease
The myocardial oxygen balance is supplied by…..
coronary blood flow, O2 carrying capacity (of blood), and vascular resistance (effects bp)
myocardial oxygen