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CELL SIZE OF MYELOBLAST

15-20 UM

CELL SIZE OF PROMYELOCYTE

15-21 UM

CELL SIZE OF MYELOCYTE

12-18 UM

CELL SIZE OF METAMYELOCYTE

10-15 UM

CYTOPLASM OF MYELOBLAST

BASOPHILIC, PRESENCE OF PRIMARY GRANULES

CYTOPLASM OF PROMYELOCYTE

BASOPHILIC

CYTOPLASM OF MYELOCYTE

BLUE-PINK

CYTOPLASM OF METAMYELOCYTE

PINK

SHAPE OF NUCLEUS OF MYELOBLAST

ROUND TO SLIGHTLY OVAL, CENTRALLY LOCATED

SHAPE OF NUCLEUS OF PROMYELOCYTE

ROUND TO OVAL, ECCENTRIC, PRESENCE OF “HOF”

SHAPE OF NUCLEUS OF MYELOCYTES

ROUND TO OVAL WITH FLATTENED SIDE

SHAPE OF NUCLEUS OF METAMYELOCYTES

INDENTED (

METAMYELOCYTES IS ALSO KNOWN AS?

JUVENILE CELLS

N:C RATIO OF MYELOBLAST

4:1

N:C RATIO OF PROMYELOCYTE

3:1 TO 2:1

N:C RATIO OF MYELOCYTE

1:1

NUCLEAR CHROMATIN OF MYELOBLAST

FINE

NUCLEAR CHROMATIN OF PROMYELOCYTE

SLIGHTLY COARSER

NUCLEAR CHROMATIN OF MYELOCYTE

COARSE

NUCLEAR CHROMATIN OF METAMYELOCYTE

COARSE AND CLUMPED

NUCLEOLI OF MYELOBLAST

2-5

NUCLEOLI OF PROMYELOCYTE

2-3

CELL SIZE OF NEUTROPHIL BAND/STAB/STAFF

9-15 UM

CELL SIZE OF NEUTROPHIL (SEGMENTED)

9-15 UM

CELL SIZE OF EOSINOPHILS

9-15 UM

CELL SIZE OF BASOPHILS

10-16 UM

CYTOPLASM OF NEUTROPHIL BAND/STAB/STAFF

LILAC-PINK GRANULES

CYTOPLASM OF NEUTROPHIL (SEGMENTED)

LILAC-PINK TO PURPLE GRANULES

CYTOPLASM OF EOSINOPHILS

COARSE REDDISH-ORANGE GRANULES

CYTOPLASM OF BASOPHILS

COARSE BLUISH-BLACK GRANULES

SHAPE OF NUCLEUS OF NEUTROPHIL BAND/STAB/STAFF

C, S, Z SHAPE, INDENTED (>1/2 OF NUCLEAR WIDTH)

SHAPE OF NUCLEUS OF NEUTROPHIL (SEGMENTED)

MULTILOBED (2-5), CONNECTED BY THIN FILAMENTS

SHAPE OF NUCLEUS OF EOSINOPHILS

BILOBED

SHAPE OF NUCLEUS OF BASOPHILS

MULTILOBED (3-4)

CELL SIZE OF MONOBLAST

12-20 UM

CELL SIZE OF PROMONOCYTES

14-18 UM

CELL SIZE OF MONOCYTES

14-20 UM

CYTOPLASM OF MONOBLAST

BASOPHILIC

CYTOPLASM OF PROMONOCYTES

BLUE-GRAY

CYTOPLASM OF MONOCYTES

BLUE-GRAY WITH GROUND GLASS APPEARANCE

SHAPE OF NUCLEUS OF MONOBLAST

ROUND TO SLIGHTLY INDENDTED WITH 1-2 NUCLEOLI

SHAPE OF NUCLEUS OF PROMONOBLAST

IRREGULARLY SHAPED WITH 0-1 NUCLEOLI

SHAPE OF NUCLEUS OF MONOCYTES

KIDNEY BEAN SHAPED WITH BRAIN LIKE CONVULSIONS

CELL SIZE OF LYMPHOBLAST

10-18 UM

CELL SIZE OF PROLYMPHOCYTE

10-18 UM

CYTOPLASM OF LYMPHOBLAST

MODERATE TO DARK BLUE

CYTOPLASM OF PROLYMPHOCYTE

MODERATE TO DARK BLUE WITH FEW AZUROPHILIC GRANULES

SHAPE OF NUCLEUS OF LYMPHOBLAST

ROUND TO OVAL, ECCENTRIC

SHAPE OF NUCLEUS OF PROLYMPHOCYTE

ROUND, OVAL, OR SLIGHTLY INDENTED

CELL SIZE OF LYMPHOCYTE

S: 7-10 UM M: 10-12 UM L: 11-25 UM

CYTOPLASM OF LYMPHOCYTES

SKY BLUE/ROBIN EGG BLUE

SHAPE OF NUCLEUS OF LYMPHOCYTES

ROUND AND COMPACT WITH CRUSHED VELVET APPEARANCE

MYELOBLAST HAS _____ NUCLEATED CELLS IN THE BONE MARROW

1-2%

PROMYELOCYTE HAS ______ OF NUCLEATED CELLS IN THE BONE MARROW

1-6%

IT IS THE STAGE OF SYNTHESIS OF **PRIMARY GRANULES/NON-SPECIFIC GRANULES/AZUROPHILIC GRANULES**

PROMYELOCYTE

MYELOCYTE IS THE LAST STAGE CAPABLE OF?

MITOSIS

IT IS THE STAGE OF SYNTHESIS OF SECONDARY/SPECIFIC GRANULES

MYELOCYTE

EARLY MYELOCYTE IS KNOWN AS?

DAWN OF NEUTROPHILIA

IT IS THE STAGE WHICH IS MOST ABUNDANT IN NORMAL BONE MARROW

METAMYELOCYTE

METAMYELOCYTE IS THE STAGE OF _______ DEVELOPMENT?

TERTIARY GRANULES

NEUTROPHIL BANDS/STAB/STAFF HAS ______ OF NUCLEATED CELLS IN THE BONE MARROW

9-32%

NEUTROPHIL BANDS/STAB/STAFF HAS ______ OF NUCLEATED CELLS IN THE CIRCULATION

0-5%

THIS IS THE YOUNGEST GRANULOCYTIC PRECURSOR TO NORMALLY APPEAR IN THE PERIPHERAL BLOOD

Neutrophil Bands/stab/staff

NEUTROPHIL BANDS IS THE SYNTHESIS OF _______

SECRETORY GRANULES

POLYMORPHONUCLEAR NEUTROPHILS (PMN) HAS _______ OF NUCLEATED MARROW CELLS

7-30%

EOSINOPHILS HAS _______ OF NUCLEATED MARROW CELLS

1-3%

IT IS CRITICAL FOR EOSINOPHIL GROWTH AND SURVIVAL

INTERLEUKIN-5

BASOPHILS HAS _____ OF CIRCULATING WBC

0-2%

BASOPHILS HAS _____ OF NUCLEATED MARROW CELLS

DEVELOPMENT AND MATURATION OF MONOCYTES

MONOPOIESIS

WHAT IS THE MACROPHAGE CALLED WHEN IT IS LOCATED IN THE **LIVER**?

KUPFFER CELLS

WHAT IS THE MACROPHAGE CALLED WHEN IT IS LOCATED IN THE **LUNGS**

ALVEOLAR MACROPHAGE/DUST CELLS

WHAT IS THE MACROPHAGE CALLED WHEN IT IS LOCATED IN THE **KIDNEYS**

MESANGIAL CELLS

WHAT IS THE MACROPHAGE CALLED WHEN IT IS LOCATED IN THE **BRAIN**

MICROGLIAL CELLS

WHAT IS THE MACROPHAGE CALLED WHEN IT IS LOCATED IN THE **SKIN**

LANGERHANS CELLS

WHAT IS THE MACROPHAGE CALLED WHEN IT IS LOCATED IN THE **SPLEEN**

SPLENIC MACROPHAGE/LITTORAL CELLS

WHAT IS THE MACROPHAGE CALLED WHEN IT IS LOCATED IN THE **BONE**

OSTEOCLASTS

WHAT IS THE MACROPHAGE CALLED WHEN IT IS LOCATED IN THE **PLACENTA**

HOFFBAUER CELLS

MOST ABUNDANT CELL IN THE BODY

MACROPHAGE

LARGEST CELL IN THE CIRCULATION

MONOCYTES

THE ONLY STAGE IN MONOPOIESIS FOUND IN THE CIRCULATION

MONOCYTES

MAJOR CYTOKINE RESPONSIBLE FOR GROWTH AND DIFFERENTIATION OF MONOCYTES

M-CSF

REFERS TO THE PRODUCTION, DEVELOPMENT, MATURATION OF LYMPHOCYTES

LYMPHOPOIESIS

WHAT IS THE 1ST MORPHOLOGICALLY RECOGNIZABLE CELLS OF THE LYMPHOPOIESIS

LYMPHOBLAST

THEY ARE SEEN IN BONE MARROW, THYMUS, AND SECONDARY LYMPHOID TISSUES

PROLYMPHOCYTE

THIS DENOTES THAT LYMPHOCYTES IS NOT NORMAL BUT DOES FURTHER CLASSIFY A LYMPHOCYTES

VARIANT LYMPHOCYTE

B CELLS ARE ALSO KNOWN AS?

SHORT-LIVE LYMPH

WHERE ARE B CELLS FOUND?

BONE MARROW

B CELLS NEEDS TO MATURE TO ______ TO BE ABLE TO PRODUCE ________

PLASMA CELLS; ANTIBODIES

T CELLS ARE ALSO KNOWN AS?

LONG-LIVE LYMPH

WHERE ARE T CELLS FOUND?

THYMUS

THIS IS A DIRECT KILLING FROM CELL TO CELL

T CELLS

NK CELLS ARE ALSO KNOWN AS?

LARGE GRANULAR LYMPHOCYTES

THESE ARE PART OF AN INNATE IMMUNITY THAT ARE CAPABLE OF KILLING CERTAIN TUMOR CELLS AND VIRUS-INFECTED CELLS WITHOUT PRIOR SENSITIZATION

NK CELLS

THIS IS THE FINAL MATURATION STAGE OF B CELLS

PLASMA CELLS

FORMED DURING METAMYELOCYTE TO BAND STAGES

TERTIARY GRANULES

FORMED DURING BAND TO SEGMENTED STAGES

NEUTROPHIL SECRETORY GRANULES

FORMED DURING MYELOCYTE STAGES

SECONDARY GRANULES

SIZE OF PLASMA CELLA

10-28 UM

SHAPE OF NUCLEUS OF PLASMA CELLS

SMALL/OVAL SHAPED, ECCENTRIC