Septic Shock and MODS Overview

These flashcards cover key terms and definitions related to septic shock and multiple organ dysfunction syndrome (MODS), emphasizing critical concepts needed for understanding the condition and treatment protocols.

Septic Shock

A condition where sepsis causes hypotension (systolic blood pressure < 90 mm Hg) despite adequate fluid resuscitation, along with organ dysfunction or perfusion abnormalities.

MODS

Multiple Organ Dysfunction Syndrome, a progressive dysfunction of 2 or more organ systems, which can be induced by various acute insults.

Clinical Manifestations

In septic shock, early symptoms include warm, flushed skin, while late symptoms show pale, cold, clammy skin and other signs of organ dysfunction.

Initial Resuscitation for Septic Shock

Administer 30 mL/kg of IV crystalloid fluid within the first 3 hours for sepsis-induced hypoperfusion.

Vasoactive Medications

Medications that support blood pressure and cardiac output in hypoperfused septic patients, with norepinephrine as the first-choice vasopressor.

Blood Culture

A laboratory test to isolate the infection source, which should be obtained within 45 minutes after suspecting sepsis.

One Hour Bundle

A set of five actions to be completed within one hour after sepsis recognition including measuring lactate levels, obtaining blood cultures, administering antibiotics, and fluid administration.

Corticosteroids in Sepsis

Anti-inflammatory medications initiated for patients with vasopressor-dependent septic shock and those with adrenal insufficiency.

Renal Support

Continuous RRT or intermittent RRT should be used for patients with sepsis and acute kidney injury.

Glycemic Control in Sepsis

Protocol to manage blood glucose levels in ICU patients with sepsis to maintain less than 180 mg/dL to reduce mortality risk.