Human Bio: Chapter 6

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Name the parts of the skeletal system

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Name the parts of the skeletal system

bones, joints, cartilages, ligaments, tendons

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What are the 2 divisions of the skeletal system?

axial and appendicular

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What are the 5 functions of the skeletal system?

  1. Support

  2. Mineral and Triglyceride Storage

  3. Blood Cell Production

  4. Production

  5. Movement

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Matrix always contains _____, _____, ____, _____, ____.

Collagen, ground substance, organic molecules, water, and minerals

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T/F: proteoglycans make up a large amount of ground substance

True

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Proteoglycans attract _______.

Water

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Proteoglycans help tissue _____________.

Withstand compression

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Tendons are

Muscle to bone

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Ligaments are

Bone to bone

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Cartilage is

Pad/cushion areas around bone

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Cells embedded with cartilage are called _____.

Chondrocytes

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What is an osteoblast?

Formation of bone matrix; repair/remodel of bone tissue; produce collagen and proteoglycans (ossification)

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What is an osteocyte?

Mature cells that maintain bone matrix

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What is an osteoclast?

Cells that break down matrix; bone cells release minerals through osteolysis

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Most minerals are in a form of _________.

Calcium phosphate

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T/F: mineral component gives weight-bearing strength and is responsible for 3/4 of the weight of the 206 bones in an adult.

False- it's responsible for 2/3 of the weight

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Osteocytes are located in spaces called ______, in the _________.

Lacunae; lamellar matrix

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Canaliculi is

Small channels that run through the matrix to transport nutrients and remove waste

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Compact bone is made of a repeating functional unit called_____.

Osteon

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Osteon is made up of concentric circles of ________.

Lamella w/ embedded lacunae; and surrounds the central canal

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What are perforating canals?

They allow for blood vessels in the central canals to linked to other vessels

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Spongy bone is located @ the ______ of ______ & at the center of other bones.

Epiphysis; long bones

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Spongy bone contains _____ interconnecting rods and spaces that contain ______.

Trabiculae; bone marrow

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T/F: spongy bone has no osteons

True

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Spongy bone is found in locations w/ ______ arriving from many different directions.

Stresses

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______ bone is much lighter than ______ bone and reduces weight of skeleton and makes it easier for muscles to move.

Spongy; compact

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What are the 4 general shapes of bones?

Long, short, irregular, flat

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What is an example of a long bone?

humerus, femur

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What is an example of a short bone?

carpals and tarsals

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What is an example of a flat bone?

Sternum, cranial bones

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What is an example of an irregular bone?

Vertebrae, hip bones, facial bones

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Which bone shape has compact bone on the inside w/ hollow central marrow cavity?

Long bone

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The epiphysis are wider portions at each end, made up of _____.

Spongy bone

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What is an epiphyseal plate?

Site of growth between diaphysis & epiphysis; solidifies into epiphyseal line when full adult height is reached

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What is a medullary cavity?

Center of diaphysis; holds red/yellow marrow

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What is periosteum?

Membrane around bone's outer surface; contains blood vessels/nerves; tendons/ligaments attach here

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What is endosperm?

Membrane that lines the medullary cavity; contains osteoblasts & osteoclasts; involved in growth & repair

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Ossification is _______.

Formation of bone by osteoblasts

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Intramembranous ossification is_______.

Bone formation occurs within connective tissue membranes

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Endochondral ossification is________.

Bone formation that occurs inside hyaline cartilage

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Both intramembranous and endochondral bone formation result in ______ and _____ bone.

Compact, spongy

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Intramembranous ossification occurs primarily in the ______ when osteoblasts begin to produce bone within connective tissue, known as mesenchyme.

Skull

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In intramembranous ossification, osteoblasts line up ________, & begin depositing bone matrix to form trabiculae, which radiate out from centers of the ossification centers.

On the surface

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____ or more _________ exist in each flat skull bone and mature skull bones result from fusion of these centers as they enlarge.

2, ossification centers

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Intramembranous ossification generally occurs during the ________ of fetal development, & forms the bones of the skull, mandible, and the clavicle.

First 2 months

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Endochondral ossification is initially formed is a ________, which is bone formation in the diaphysis of a long bone.

Primary ossification center

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__________ is bone formation in the epiphysis.

Secondary ossification center

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What are the steps in endochondral ossification?

  1. Chondroblasts build a cartilage model, then become chondrocytes

  2. Cartilage model hardens (calcifies)

  3. Osteoblasts invade calcified cartilage and a primary ossification center forms the diaphysis

  4. Secondary ossification centers form the epiphysis

  5. Original cartilage model is almost completely ossified; remaining cartilage is known as articular cartilage

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During bone growth, when cartilage is broken down, the enclosed cartilage is digested away which opens up a _______.

Medullary cavity

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Bone replaces _____ through the action of _____.

Cartilage, osteoblasts

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Dying chondrocytes are replaced by ______.

Osteoblasts

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Bones grow in width by the periosteum & the existing matrix _______.

Appositional growth

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What are the requirements for bone growth?

Mineral supply, vitamin D3, hormones, & vitamins A, B, C, D, K

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T/F: timing of epiphyseal closure varies from bone-bone and from person-person

True

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Bones are remodeled in response to what 2 factors?

  1. Free calcium levels in the blood

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  1. Pull of gravity & muscles on the skeleton

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Bone remodeling involves:

-removal of existing bones by osteoclasts

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-deposition of new bones by osteoblasts

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In young adults ____ of the skeletal mass is replaced each year.

1/5

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T/F: spongy bone is replaced more often than compact

True

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In adults, osteocytes in lacunae continuously _____ & _____ surrounding calcium salts.

Remove, replace

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Remodeling bone (esp. spongy bone) is based on:

Appropriate stress & exercise

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T/F: muscle is a major storage site for calcium

False- bone is major storage site

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Calcium homeostasis is maintained by _____ & ______.

Parathyroid hormone, calcitonin

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Parathyroid hormone (increase or decrease) formation/activation of osteoclasts.

Increase

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A closed fracture is

Simple; completely internal and only seen on x-rays

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An open fracture is

Compound; project through the skin and are at most risk for infection

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What are the steps in bone repair?

  1. Broken bone causes bleeding and a fracture hematoma forms

  2. Cells of periosteum/endosteum divide to form a callus(internal/external)

  3. Cartilage model forms first, then osteoblasts enter the callus and form spongy bone; continues for 4-6 weeks after injury

  4. Cancellous bone is slowly remodeled to form compact & cancellous bone

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When placed under stress, tissue becomes stronger through ________ & production of collagen fibers.

Increased decomposition of mineral salts

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Without mechanical stress, bone does not remodel normally because ________.

Resorption out-spaces bone formation

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When there's an absence of mechanical stress, bone weakens through decreased # of ______ and demineralization (loss of bone minerals).

Collagen fibers

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What is osteopenia?

Inadequate ossification that naturally occurs in aging as early as 30-40 years old

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Osteoblasts _____.

Slow

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Osteoclasts _____.

Remain constant

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What is osteoporosis?

Loss of bone mass that impairs normal function and can lead to more fractures

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T/F: osteoporosis is more severe that osteopenia

True

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Osteoporosis is more common in what gender?

Females

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For women, osteoporosis usually accelerates after _____ due to decline in circulating estrogen.

Menopause

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Foramen is

A large hole/opening

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Fossa is

depression

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Process is

Projection

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Condyle is

Smooth, round ended

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Meatus is

Canal-like passageway

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Tubercle is

Lump of bone

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