E. coli: Disease

5 infections of enterobacterales

1. SST

2. UTI

3. Bloodstream infections

4. Intraabdominal infections

5. Lower respiratory infection

Escherichia, Shigella similarity (2)

1. Similar at genetic level

2. There are E. coli that don’t ferment lactose

   1. Confused as shigella

Disease specific to E. coli (1)

1. Neonatal meningitis

Strains that cause GI illness

Enterotoxigenic E. coli (ETEC)

Enterohemorrhagic E. coli (EHEC)

Enteroinvasive E. coli (EIEC)

EHEC toxin (3)

1. Toxin damages endothelial cells that line the intestine

2. Toxin similar to shigella disentarae

   1. “Shigella-like toxin”

3. Also known as STEC “Shigella toxin E. coli”

Symptoms of EHEC (5)

1. Abdominal cramps

2. Watery diarrhea with blood

3. Afebrile (No fever)

4. No WBC in stool

5. Can progress to HUS (Hemolytic uremic syndrome)

Distribution of EHE in US (4)

1. 5000 reported to CDC (National notifiable disease)

2. Kids can progress to HUS

   1. 250 reported

   2. 25 deaths

HUS Symptoms (3)

1. Acute renal failure

2. Thrombocytopenia

3. Microangiopathic hemolytic anemia

Major outbreak (5)

• E. coli H7:O157

  • H = Flagella

  • O = somatic antigen

• Jack in the Box had 600 culture-confirmed cases

• lead to 180 hospitalizations

• 40 progressed to HUS

• 4 died