Unit 5 Energy electron transport chain

Inner mitochondrial membrane

The Electron Transport Chain (ETC) Is

Located In The _____ _____ _____

FADH2 & NADH

____ _____ supply energy rich electrons to the electron transport chain

• food molecules provide energy to make ____ ____

Electron transport chain

The _____ _____ _____ generates the hydrogen ion concentration gradient across the inner mitochondrial membrane

• Electron (e-) Flow Energizes 3 ETC Protein Complexes To Transport H+ Ions Across The Inner Mitochondrial Membrane Into The Intermembrane Space

• The H+ Ion Concentration Gradient That Forms Is An Energy Source

ATP synthase

The Hydrogen Ion (H+) Concentration Gradient Across The Inner Mitochondrial Membrane Energizes ____ _____

• Each ATP Synthase Enzyme Makes ~400 ATP Molecules/Second

  • The Inner Mitochondrial Membrane Contains Many ATP Synthase Enzymes

2

ATP synthase has ____ parts

• H+ Ions Diffuse Through

  The F0 Part In The Inner

  Mitochondrial Membrane

   The Active Site In The F1

  Part Adds PO4 (Pi) To ADP

  To Make ATP

  • The Diffusion Of H+ Ions

  Through The F0 Part

  Activates The F1 Part

~100-400

____ ATP molecules are made per second

Cytosol

ATP molecules made in mitochondria must be exported to the Cytosol to supply cells with energy

Adenine Nucleotide Translocator (NAT)

Transports ATP across the inner mitochondrial membrane

• ____ is the most abundant protein I. The inner membrane

Total ATP Production During Cellular Respiration

• Glycolysis Results In 7-8 ATP Per Glucose Molecule

 Pyruvate Oxidation Results In 5-6 ATP

Per Glucose Molecule

 Krebs Cycle Results In 20-24 ATP Per

Glucose Molecule

Oxygen

Aerobic Species Require _____ To Perform Cellular Respiration

 O2 Removes Electrons (e-) From The ETC To Enable The -

• Electrons To Continue Flowing Through The ETC

• H+ Ion Concentration Gradient To Continue Forming

• Continued Activation Of ATP Synthase To Make ATP

Cyanide

_____ is a lethal metabolic poison

- Cyanide Inhibits Cytochrome C Oxidase To Eliminate -

• Electron Flow Through The ETC

• H+ Ion Concentration Gradient Formation

• ATP Synthesis By ATP Synthase

Dinitrophenol (DNP)

______ reduces ATP synthase

• DNP Transports H+ Ions Across The Inner Mitochondrial Membrane

• Fewer H+ Ions Are Available To Activate ATP Synthase

DNP

___ Is A Potential Treatment For Metabolic

Syndrome, Neurodegenerative Disorders, And Obesity