Ceutics II Quiz 1

Induced electrostatic interaction will release ____ than 40 kJ/mol upon formation and bring the interacting atoms ____ than 0.2 nanometers.

a) less; farther

b) less; closer

c) more; farther

d) more; closer

a) less; farther

Which interaction exhibits the strongest directionality of formed bonds?

a) covalent bond

b) electrostatic interaction

c) hydrogen bond

d) dispersion interaction

a) covalent bond

Hydrogen bond will release ____ than 40 kJ/mol upon formation and bring the interacting atoms ____ than 0.2 nanometers.

a) less; closer

b) less; farther

c) more; farther

d) more; closer

b) less; farther

Which of the following electrostatic interactions has the longest range?

a) ion-dipole

b) ion-ion

c) ion-induced dipole

b) ion-ion

Charge-transfer complexes are formed by aromatic rings, donor and acceptor. The donor ring has ____ ionization potential and the acceptor ring has ____ electron affinity.

a) high; high

b) low; high

c) high; low

d) low; low

b) low; high

Order the media according to increasing ability to shield electrostatic interactions.

Column A:

1

2

3

Column B:

vacuum

nonpolar phase (e.g. the core of the membrane)

water

1 ---- vacuum

2 ---- nonpolar phase (e.g. the core of the membrane)

3 ---- water

The only interaction that can be both attractive and repulsive is ____ .

a) hydrophobic interaction

b) dispersion interaction

c) electrostatic interaction

d) hydrogen bond

c) electrostatic interaction

The dipole moment is the ____ of the charge in the centers of positive and negative charges and the distance between the centers.

a) product

b) sum

c) difference

d) ratio

a) product

Select all weak interactions.

a) electrostatic ion-dipole interaction

b) dispersion interaction

c) hydrophobic interaction

d) covalent bond

e) coordination bond

f) short-range repulsion

g) electrostatic interaction between partial charges

a) electrostatic ion-dipole interaction

b) dispersion interaction

c) hydrophobic interaction

f) short-range repulsion

g) electrostatic interaction between partial charges

Select all heteroatoms.

a) P

b) S

c) C

d) N

e) H

f) O

a) P

b) S

d) N

f) O

The strength of which interaction is inversely proportional to the distance between interacting atoms?

a) hydrogen bond

b) hydrophobic interaction

c) electrostatic ion-ion interaction

d) electrostatic ion-dipole interaction

e) dispersion interaction

c) electrostatic ion-ion interaction

The strongest interatomic interaction in the given set is ____ .

a) hydrogen bond

b) coordination bond

c) dispersion interaction

d) charge-transfer interaction

b) coordination bond

Select the interaction that only has a significant magnitude if the interacting objects are of large size.

a) nuclear

b) gravitational

c) electromagnetic

b) gravitational

Coordination bond will release ____ than 40 kJ/mol upon formation and bring the interacting atoms ____ than 0.2 nanometers.

a) less; farther

b) more; farther

c) less; closer

d) more; closer

d) more; closer

Covalent bond will release ____ than 40 kJ/mol upon formation and bring the interacting atoms ____ than 0.2 nanometers.

a) less; farther

b) more; closer

c) less; closer

d) more; farther

b) more; closer

Carbons and associated hydrogens in drug molecules usually participate in ____ .

a) hydrophobic interactions

b) covalent bonds

c) electrostatic interactions

d) hydrogen bond formation

a) hydrophobic interactions

Charge-transfer interaction will release ____ than 40 kJ/mol upon formation and bring the interacting atoms ____ than 0.2 nanometers.

a) more; closer

b) less; farther

c) more; farther

d) less; closer

b) less; farther

Which of the following interactions cannot occur in a nonpolar medium?

a) short-range repulsion

b) hydrophobic interaction

c) dispersion interaction

d) covalent bond

b) hydrophobic interaction

One nanometer is ____ angstroms.

a) 100

b) 0.01

c) 10

d) 0.1

c) 10

Halogen bond is mainly formed by ____ interaction.

a) electrostatic

b) dispersion

c) charge-transfer

d) induced electrostatic

a) electrostatic

Select all atoms that can form halogen bonds if attached to an electron-withdrawing skeleton.

a) chlorine

b) iodine

c) bromine

d) fluorine

a) chlorine

b) iodine

c) bromine

Aromatic stacking is caused mainly by ____ interaction.

a) dispersion

b) induced electrostatic

c) electrostatic

d) H-bonding

a) dispersion

The energy of the ion-dipole interaction is inversely proportional to the ____ between the ion and the center of the dipole.

a) square of distance

b) cubed distance

c) distance

d) the square root of distance

a) square of distance

Aromatic stacking can form ____ aggregates.

a) face-to-face

b) cylindrical

c) T-shaped

d) parallel staggered

a) face-to-face

c) T-shaped

d) parallel staggered

Match the characteristics of the Coulomb law describing the energy of electrostatic interaction. The energy (Column B) (Column A).

Column A:

charges

permittivity

distance

type of atom

Column B:

is proportional to

does not depend on

is inversely proportional to

depends in a nonlinear way

charges ---- is proportional to

permittivity ---- is inversely proportional to

distance ---- is inversely proportional to

type of atom ---- does not depend on

Selects all parts of drug molecules that participate in dispersion (van der Waals) interactions.

a) hydrogens bound to heteroatoms

b) carbons

c) hydrogens bound to carbons

d) heteroatoms

a) hydrogens bound to heteroatoms

b) carbons

c) hydrogens bound to carbons

d) heteroatoms

Electronegative atoms in a molecule will bear a partial ____ charge because they ____ electrons in the bonds they form.

a) positive; repel

b) positive; attract

c) negative; attract

d) positive; repel

c) negative; attract

The ion-dipole interaction will release ____ than 40 kJ/mol upon formation and bring the interacting atoms ____ than 0.2 nanometers.

a) less; closer

b) more; closer

c) less; farther

d) more; farther

c) less; farther

Strong interaction liberates ____ upon formation.

a) more than 0.2 kJ/mol

b) less than 40 kJ/mol

c) less than 0.2 kJ/mol

d) more than 40 kJ/mol

d) more than 40 kJ/mol

Selects all parts of drug molecules that participate in hydrophobic interactions.

a) carbons

b) heteroatoms

c) hydrogens bound to carbons

d) hydrogens bound to heteroatoms

a) carbons

c) hydrogens bound to carbons

Interactions among drug molecules and physiologic molecules are ____ interactions.

a) other

b) electromagnetic

c) nuclear

d) gravitational

b) electromagnetic

The strength of which interaction is proportional to the magnitude of the charges of interacting atoms?

a) hydrophobic interaction

b) hydrogen bond

c) dispersion interaction

d) electrostatic interaction

d) electrostatic interaction

Match interactions and their classifications.

Column A:

covalent bond

H-bond

charge transfer

dispersion interaction

hydrophobic interaction

electrostatic interaction

short-range repulsion

Column B:

attractive

repulsive

can be attractive or repulsive

covalent bond ---- attractive

H-bond ---- attractive

charge transfer ---- attractive

dispersion interaction ---- attractive

hydrophobic interaction ---- attractive

electrostatic interaction ---- can be attractive or repulsive

short-range repulsion ---- repulsive

Water shield electrostatic interactions about ____ times more than nonpolar media.

a) five

b) hundred

c) forty

d) ten

c) forty

Which interaction can be both attractive and repulsive?

a) dispersion interaction

b) hydrophobic interaction

c) electrostatic interaction

d) hydrogen bond

c) electrostatic interaction

Dispersion interaction will release ____ than 40 kJ/mol upon formation and bring the interacting atoms ____ than 0.2 angstroms.

a) less; closer

b) more; farther

c) more; closer

d) less; farther

d) less; farther

____ interaction is the strongest for the particles of the same size.

a) Nuclear

b) Gravitational

c) Electromagnetic

a) Nuclear

A complex formed by weak interactions has structure that is ____ the sum of structures of interaction partners and its formation is ____ .

a) different from; fast

b) identical with; slow

c) different from; slow

d) identical with; fast

d) identical with; fast

Which of the following interactions can only happen in an aqueous medium?

a) dispersion interaction

b) hydrophobic interaction

c) short-range repulsion

d) covalent bond

b) hydrophobic interaction

____ interaction will bring the interacting particles at the shortest distance.

a) Electromagnetic

b) Nuclear

c) Gravitational

b) Nuclear

Selects all parts of drug molecules that act as hydrogen bond acceptors.

a) hydrogens bound to carbons

b) hydrogens bound to heteroatoms

c) heteroatoms

d) carbons

c) heteroatoms

The dipole moment of the symmetric molecule of carbon dioxide is ____ esu x cm.

a) 1

b) 2

c) 3

d) 0

d) 0

Which interaction can connect two aromatic rings, one being electron-rich and the other being electron-deficient?

a) charge-transfer interaction

b) electrostatic interaction

c) hydrophobic interaction

d) covalent bond

a) charge-transfer interaction

The electrostatic interaction of the same ion pair is about ____ in water than in lipoid phase. The charges are of opposite signs, the distances are identical in both media.

a) 40 times weaker

b) 2 times stronger

c) 10 times stronger

d) 2 times weaker

a) 40 times weaker

Select the interaction that acts at the longest distance between interacting atoms.

a) electrostatic interaction

b) charge-transfer interaction

c) hydrogen bond

d) covalent bond

a) electrostatic interaction

Charge-transfer complexes can be formed by ____ .

a) oxygens

b) aromatic rings

c) carbons

d) nitrogens

b) aromatic rings

Which of the following interactions can form between any atom pair?

a) ionic bond

b) hydrophobic interaction

c) coordination bond

d) electrostatic interaction

e) covalent bond

f) short-range repulsion

g) dispersion interaction

f) short-range repulsion

g) dispersion interaction

Covalent bonds are ____ nm long.

a) 0.3 - 0.4

b) 0.2 - 0.3

c) 0.0 - 0.1

d) 0.1 - 0.2

d) 0.1 - 0.2

Selects all parts of drug molecules that act as hydrogen bond donors.

a) carbons

b) hydrogens bound to carbons

c) heteroatoms

d) hydrogens bound to heteroatoms

d) hydrogens bound to heteroatoms

Dispersion interaction will bring the interacting particles ____ .

a) closer than 0.1 nm

b) closer than 0.15 nm

c) farther than 0.2 nm

d) closer than 0.2 nm

c) farther than 0.2 nm

Select all interactions that will always form within seconds in a homogeneous solution.

a) hydrogen bond

b) covalent bond

c) charge-transfer interaction

d) electrostatic interaction

e) coordination bond

f) hydrophobic interaction

g) dispersion interaction

a) hydrogen bond

c) charge-transfer interaction

d) electrostatic interaction

f) hydrophobic interaction

g) dispersion interaction

The ability of the medium to shield the electrostatic interactions is characterized by ____ .

a) the dielectric constant

b) the Avogadro's constant

c) the universal gas constant

d) temperature

a) the dielectric constant

Select all strong interactions.

a) hydrophobic interaction

b) electrostatic interaction

c) ionic bond

d) coordination bond

e) hydrogen bond

f) covalent bond

g) induced electrostatic interaction

c) ionic bond

d) coordination bond

f) covalent bond

Electrostatic interaction between atoms with partial charges will release ____ than 40 kJ/mol upon formation and bring the interacting atoms ____ than 0.2 nanometers.

a) less; closer

b) less; farther

c) more; closer

d) more; farther

b) less; farther

Selects all parts of drug molecules that participate in short-range repulsion interactions.

a) heteroatoms

b) carbons

c) hydrogens bound to carbons

d) hydrogens bound to heteroatoms

a) heteroatoms

b) carbons

c) hydrogens bound to carbons

d) hydrogens bound to heteroatoms

Select the atoms that can act as donors in hydrogen bonds.

a) carbons

b) hydrogens bound to carbons

c) hydrogens bound to heteroatoms

d) heteroatoms

c) hydrogens bound to heteroatoms

The dipole moment of the symmetric molecule of carbon tetrachloride is ____ esu x cm.

a) 2

b) 3

c) 0

d) 1

c) 0

The hydrogen bond will convert to an electrostatic interaction, if the angle between the three participating atoms (two electronegative atoms and hydrogen) falls below ____ degrees.

a) 160

b) 170

c) 180

d) 150

d) 150

The Coulomb's law says that the energy of interaction is proportional to the ____ and inversely proportional to the ____ .

a) charges; distance

b) distance; permittivity

c) permittivity; charges

d) distance; charges

a) charges; distance

Ionic bond will release ____ than 40 kJ/mol upon formation and bring the interacting atoms ____ than 0.2 nanometers.

a) more; closer

b) less; closer

c) more; farther

d) less; farther

a) more; closer

Which interaction is described by the Coulomb Law?

a) electrostatic interaction

b) hydrophobic interaction

c) hydrogen bond

d) dispersion interaction

a) electrostatic interaction

Aromatic stacking is caused by ____ interaction.

a) dispersion

b) electrostatic

c) induced electrostatic

d) H-bonding

a) dispersion

b) electrostatic