Hemostasis and Coagulation Tests

questions over the lecture

Hemostasis

complex physiologic process regulating clot formation and degradation

Platelets

_______ play a major role in plaque rupture and arterial thrombosis

deep veins

clot formation location for venous thromboembolism

Coagulation cascade

_____ play a major role in clotting factors for venous thromboembolism

100 billion new platelets daily

amount of new platelets daily

7-10 days

life span of a platelet

bone marrow

location of platelet formation

spleen, liver, and bone marrow

organs that remove platelets

Thrombocytopenia

low platelet count

thrombocythemia/ thrombocytosis

high platelet count

bleeding with trauma

level of platelets less than 50,000

spontaneous bleeding

level of platelets less than 20,000

mean platelet volume

measurement of the relationship between platelet size and count

mean platelet volume function

used to distinguish between hypoproductive and hyperdestructive causes

Aspirin

inhibits pathway of platelet activation —→ TXA2

Clopidogrel, prasugrel, ticagrelor, and cangrelor function

P2Y12 antagonists

Abciximab, Eptifibatide, and tirofiban

GPIIb/IIa antagonist

Vorapaxar

PAR1 antagonists

PT/INR

test used to monitor warfarin ad hepatic function

aPTT

test used to monitor heparin and DTI

AntiXa

test used to look at low molecular weight heparins

venous thromboembolism

deep venous thrombosis and pulmonary embolism are examples of what?

TT test

test that measures fibrinogen—> fibrin

prolongation of aPTT

caused by:

heparin, DTIs, clotting factor deficiencies, liver dysfunction, vitamin K deficiency, warfarin, DIC, and myeloproliferative disease

activated clotting time

test that measures high doses of heparin

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