Module 11

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Exam 3

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110 Terms

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HCN channels
cardiac pacemaker channels that open in response to hyperpolarization; AKA funny channels
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afterload/ESV
amount of blood remaining in the ventricle following contraction
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systemic circulation
blood flow to and from virtually all tissues of body
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vein
any vessel returning blood to the heart
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pacemaker potenial
spontaneous depolarization of the pacemaker region of the heart; SA node
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cardiac cycle
repeating pattern of systole and diastole of the atria and ventricles
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erythrocyte
red blood cell
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agglutinate
clumping of cells as a result of chemical interactions between surface antigens and antibodies
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isovolumetric ventricular relaxation
AV and semilunar valves are closed; early phase of ventricular diastole
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cardiac output
volume of blood pumped by either the right or left ventricle each minute
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sounds of karotkoff
turbulent flow of blood through the constricted artery creating sounds
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stroke volume
amount of blood ejected from each ventricle at each heartbeat
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preload/EDV
amount of blood in the ventricle just prior to contraction; in the ventricles of the heart the tension on the ventricular walls produced by filling w/blood
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interstitial fluid
fluid outside the cells within organ; this plus plasma equals extracellular fluid
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hemostasis
cessation of bleeding
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osmoreceptor
sensory neuron that responds to changes in osmotic pressure of surrounding fluid
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pulse pressure
difference between diastolic and systolic pressures
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barorectpor
receptors for arterial blood pressure located in the aortic arch and the carotid sinuses
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plasma
fluid portion of the blood
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artery
thick walled elastic vessels that carry blood away from the heart
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systole
phase of ventricular contraction in the cardiac cycle
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fibrin
insoluble protein formed from fibrinogen by the enzymatic action of thrombin during blood clot formation
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capillary
smallest blood vessels; most exchange of nutrients and waste occurs with interstitial fluid
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Frank-Starling law of the heart
describes the relationship between EDV and stroke volume. a great amount of blood prior to contraction results in a greater stretch of the myocardium
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pulmonary circulation
part of vascular system that includes pulmonary arteries and pulmonary veins. transports blood from right ventricle of the heart through the lungs and back to the left atrium of the heart
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hemoglobin
protein in red blood cell that transports oxygen
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atrioventricular valves
one way valves located between atria and ventricles
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platelet plug
layers of platelets at the site of an injury
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diastole
phase of ventricular relaxation which the heart fills with blood
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sinoatrial node
pacemaker of the heart, bundle of cardiac tissue
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circulatory/cardiovascular system function
* transport oxygen/CO2, products of digestion, waste
* regulate hormones and temperature
* clotting, immune
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circulatory system cells
* myocardial cells
* node (pacemaker) cells
* erythrocytes
* endothelial cells
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atria empty into
ventricles
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tricuspid valve
permits blood flow from atrium to ventricles but not backward
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left AV/mitral
bicuspid
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right AV
tricuspid
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pulmonary valve
right ventricle to pulmonary trunk
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aortic valve
left ventricle to aort
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conducting system
special cells are in electrical contact with cardiac muscle cells via gap junctions
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conducting system function
initiates heartbeat and helps spread action potential
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step 1 of electrical excitation of the heart
* signal starts in SA node located in right atrium
* both atria contract practically together
* discharge rate of SA node determines heart rate
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step 2 of electrical excitation of the heart
AP jumps from cell to cell via gap junctions
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step 3 of electrical excitation of the heart
AP passage through AV node is slow
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step 4 of electrical excitation of the heart
after AV node is excited, AP moves down septum to the Bundle of His
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AV node and Bundle of His
separates atrial and ventricular contraction
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step 5 of electrical excitation of the heart
bundle of His divides left and right
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step 6 of electrical excitation of the heart
Purkinji fibers spread potential quickly through out ventricles causing them to depolarize practically together
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excitation of SA node
slow predictable depolarization called pacemaker potential

* maintained by ion channels
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step 1 of excitation of SA node
K+ channels gradually closing from previous AP
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step 2 of excitation of SA node
HCN channels open in response to hyperpolarization and Na+ enters causing spontaneous depolarization to start
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step 3 of excitation of SA node
___ provide final depolarizing boost (Ca2+?)
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step 4 of excitation of SA node
Ca2+ influx through _____, long AP
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step 5 of excitation of SA node
K+ opens, causing repolarization
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step 6 of excitation of SA node
cycle repeats, no stimulus needed, return to negative potentials activates the cycled to begin all over
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step 1 of cardiac AP (myocardial cells)
voltage gated Na+ open, causing depolarization
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step 2 of cardiac AP (myocardial cells)
opening of transient K+ channels
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step 3 of cardiac AP (myocardial cells)
L type Ca2+ channels open slow and balance charge leaving through K+ (plateau phase)
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step 4 of cardiac AP (myocardial cells)
L type Ca2+ close and K+ open, causing repolarization
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long refractory period of the heart prevents
summation and tetanus
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long refractory period of the heart allows
heart to refill with blood

* almost as long as contraction itself
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electrocardiogram
electrical signals resulting from cardiac APs can be measured from fluid around the heart by placing electrodes on body to pick up movement of ions
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P wave
atrial depolarization
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QRS complex
ventricular depolarization
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T wave
ventricular repolarization
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atrial repolarization typically…
doesn’t register with electrocardiogram and happens at the same time as QRS complex
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waves on ECG may vary depending on…
placement of electrodes
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bradycardia
cardiac rate slower than 60 bpm
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tachycardia
cardiac rate faster than 100 bpm
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sinus
normal rhythm
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cardiac cycle includes
all events involved with flow of blood through the heart in 1 beat
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isovolumetric ventricular contraction
beginning of systole, all valves closed
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isovolumetric ventricular relaxation
early diastole, all valves closed
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increasing pressure in ventricles leads to
aortic and pulmonary valves opening and blood ejection
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when AV valves open…
blood flows into ventricles from atria
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normal heart sounds
“lub, dub”
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first sounds (lub)
closing of AV valves, onset of systole
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second sound (dub)
closing of pulmonary and aortic valves, onset of diastole
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SV (stroke volume)
volume of blood ejected from each ventricle during systole or with each beat of the heart
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SV equation
end diastole volume - end systole volume
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most important factor causing stretch
amount of blood in ventricles
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greater stretch means
more forceful contraction
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increase in venous return forces
increase in CO by increasing EDV which increased SV
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total peripheral resistance
combined resistance to flow of all systemic blood vessels
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blood plasma function
carries blood cells, proteins, nutrients, metabolic wastes, etc being transported around the body
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plasma volume
osmoreceptors in hypothalamus cause the release of ADH from the posterior pituitary gland if fluid is lost
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erythrocyte function
shape allows for high surface area to volume ratios so O2 can diffuse quickly
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erythrocytes produced in
bone marrow
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erythrocyte struction
no nucleus, no organelles, don’t produce, don’t live long
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dead erythrocytes
destroyed by spleen and liver
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erythrocytes contain lots of
hemoglobin
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antigen
found on surface of cells to help immune system recognize self cells
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antibodies
secreted by lymphocytes in response to foreign cells
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immediate response to bleeding
constrict vessels
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ultimate stopping of bleed depends on
formation of platelet plug and clotting
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platelet plug forms by
adhering to the surface of exposed collagen fibers
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von willebrand factor
protein that holds the binding in place
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clotting/coagulation
going from liquid to a solid gel (due to proteins fibrinogen and fibrin)
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main hemostatic defense mechanism
clotting
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blood clot function
support platelet plug
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arteries act as
pressure reservoir that maintains blood flow through tissues