ch 6

RNA Virus Genomes

Single molecules segmented can be positive negative and be sense double stranded circular and it needs to have a positive strand mRNA for protein, synthesis, and copy of RNA genome in order to make it

RDRP

No coolant I’m sorry Gino of all viruses except retrovirus in code RDRP negative strand must bring our DRP protein with it to the cell to make positive mRNA and genome

I identification of RNA polymerous

Discovered in negative strand virus articles sequencing showed conservative motives. See if this is of Recombinant RNA race and crystal structures

RNA poly - in viruS particle

Coded with protein, brains, RNA, polymerase, protein, and virus particles in nucleic gas with other accessory proteins, stable, ribbon, nucleic, protein, comprises resistant RNA

+ strand, RNA genomes, RNA, libra, and virus particles

Naked, nothing else is needed. Aryn is ready to be translated, exceptions and retrovirus and coronavirus.

dsRNA rna poly in virus particle

Have to contain RNA in the particle

Structure of viral, ribonucleic proteins

Model of influenza a virus ribbon nuclear protein polymer complex is bound to short NP – RNA template

Rules about viral RNAs

RNA Geo must be copied and end with no loss of nucleotides sequence must provide viral mRNA that can be efficiently translated by cellular ribosome

Universal rules for RNA directed rna synthesis

Initiate and terminate specific sites on template or DRP may initiate synthesis stain will require a primer other viral and cellular proteins may be required Erney synthesize and template directed stepwise incorporation of NTP’s 5 to 3 some non-template synthesis extra basis are added, and it’s rare

Initiation of RNA synthesis

De novo and primer dependent initiation

De Nova

does not require a primer and it elongate slips back

In initiation of RNA synthesis primary dependent

Protein primer and then you have a cap primer structure at the five end of a mRNA

What are the metals involved in polymerous catalyst?

2 Magnesium

Protein domain alignment of four categories of nucleic acid poly raises

RNA/ RNA, RNA/DNA, DNA/DNA, DNA/RNA