Lec 14 GI Accessory Glands & Organs: Biol 302 Histology Midterm #2

What are the Accessory Glands?

Liver, Gall bladder, Pancreas

Functions of Liver?

Production of bile, hor, serum proteins

Detoxification of blood

Storage of nut and Vit A

Phagocytosis of debris and dead cells

Blood supply (aff = portal vein and hepatic artery…eff = hepatic vein)

Breakdown the Liver structure?

Mesothelium; simple squam epit w/ DICT below

Glisson’s capsule surr whole liver (collagenous T)

Lobule = Hepatocytes + Sinusoids + Central Vein + Portal Triad (Portal venule, Hepatic arterioles, Bile ductules…Lymphatic vessels)

Identify the Organ and Structures?

Liver; Mesothelium, Hepato, Sinu

Identify the Organ and Structures?

Liver; Lobule w/ Central vein, surr by Hepato and Sinu, Portal triads in corners

Identify the Organ and Structures?

Liver; Lobule w/ Central vein, surr by Hepato and Sinu, Portal triads in corners

Identify the Organ and Structures?

Liver; Lobule w/ Central vein, surr by Hepato and Sinu, Portal triads in corners

Identify the Organ and Structures?

Liver; Lobule w/ Central vein, surr by Hepato and Sinu, Portal triads in corners

Identify the Organ and Structures?

Liver; Central vein, surr by Hepato and Sinu

What is in the Portal Triad?

Portal venule (simple squam), Hepatic arterioles (simple cuboidal), Bile ductules…Lymphatic vessels

Identify the Organ and Structures?

Liver; Lobule w/ Central vein, surr by Hepato and Sinu, Portal triads in corners

D = Pv on top, Bd on left, Ha on right, C = Bd

Identify the Organ and Structures?

Liver;

1 = Bile duct

2 = Hepatocytes

3 = Sinusoids

4 = Portal Vein

5 = Hepatic arteriole

Identify the Organ and Structures?

Liver;

1 = Ha

2 = Ha

3 = Bd

4 = Bd

5 = Bd

6 = Pv

7 = Pv

Function of Hepatocytes?

abs and processing of nutrients

prod and sec of plasma prot and bile

How is bile made?

Hepato → bile cancaliculae → bile ductules → common hepatic D → Gallbladder → common bile D → Duodenum

Identify the Organ and Structures?

Liver; Hepatocytes (polyploidy)

Identify the Organ and Structures?

Liver; Lines are bile canaliculae, lighter areas = Sinusoids, darker areas with nuc = Hepato

Identify the Organ and Structures?

Liver; reticulin f and how it holds Hepatocytes tgth

Identify the Organ and Structures?

Liver; bile canaliculae

Identify the Organ and Structures?

Liver; bile ductules w/ simple cuboidal epit

Identify the Organ and Structures?

Liver; bile ductules w/ simple cuboidal epit

Function of Sinusoids?

modified capi that are discontinuous and look fenestrated

they deliver nutrients and pick up proteins

Identify the Organ and Structures?

Liver;

1 = Space of Disse

2 = Sinusoid

3 = Endothelium (simple squam)

4 = Hepatocyte

Identify the Organ and Structures?

Liver; sinusoids (simple squam)

Function of Space of Disse?

intimate contact w/ hepatocyte MV and sinusoid, support is reticular f/Stroma

Identify the Organ and Structures?

Liver; MV of hepato next to dark on the L, D = space of Disse, L of cow print is endothelium of suni

Function of Kupffer cell?

macrophage that removes debris and erythrocytes, needs trypan blue

Identify the Organ and Structures?

Liver; dark cells are Kupffer cell, Sinu

Identify the Organ and Structures?

Liver; lighter areas = Sinusoids, darker areas with nuc = Hepato, darker spots = Kupffer cells

Function of Gallbladder?

storage and concentration of bile, comes from liver via Hepatic D, then leaves via common Bile D to SI

Abs w/ MV on simple columnar epit

Identify the Organ and Structures?

Gallbladder; can see finger like Villi w/ holes, also see simple columnar epit below MV

Function of Pancreas?

mixed (mostly exo) Glands that sec zymogens and bicarbonate. Have islets of langerhans

Breakdown the Pancreas glands

the G is a compound acinar G; acinus = secretory, duct = transport and modification

acini portion → small cavity surr by secre cells of trypsinogen and Golgi

duct portion → intercalated D, intraobular D, pancreatic D

Endocrine in Pancreas?

Islets of Langerhans (lighter areas)

• Beta Cells - insulin

• Alpha Cells - glucagon

• Delta Cells - somatostatin

• PP Cells - pancreatic polypeptide

Identify the Organ and Structures?

Pancreas; (splotchy) islets of langerhans (lighter), acinar G (darker outside)

Identify the Organ and Structures?

Pancreas; acinar G looks like flower

Identify the Organ and Structures?

Liver; Mesothelium, Hepato, Sinu

Identify the Organ and Structures?

Liver; Hepatocytes, some being binucleate which is common

Identify the Organ and Structures?

Liver; Hepatocytes, some being binucleate which is common

Identify the Organ and Structures?

Liver; reticulin f and how it holds Hepatocytes tgth

Identify the Organ and Structures?

Liver; Lobule w/ Central vein, surr by Hepato and Sinu, Portal triads in corners

Identify the Organ and Structures?

Gallbladder; can see finger like Villi but holes not rlly seen?

Identify the Organ and Structures?

Pancreas; (splotchy) islets of langerhans (lighter), acinar G (darker outside)

Identify the Organ and Structures?

Pancreas; acinar/exocrine G (flower)

Identify the Organ and Structures?

Harder for me…Pancreas; (splotchy) islets of langerhans (lighter), acinar G (darker outside)

Identify the Organ and Structures?

Pancreas; (splotchy) islets of langerhans (lighter), acinar G (darker outside)