Orgo 2 Test 3 Reactions

Topics for midterm-3 (Ch-18 and Ch-19)

Topics for midterm-3 (Ch-18 and Ch-19)

1) Acidity of alpha-hydrogens of carbonyl compounds and esters

2) Keto-enol tautomerism under acidic and basic conditions

3) Enolate formation from carbonyl compounds and esters, kinetic vs. thermodynamic enolates

4) Alkylation of enolates

5) Limitation of enolate alkylation

6) Alkylation at alpha position of carbonyl compounds via enamine formation

7) Synthesis of alpha-substituted acetic acid using DEM

8) Synthesis of alpha-substituted acetone using EAA

9) Halogenation of carbonyl compounds under acidic and alkaline conditions

10) Aldol condensation (intra and intermolecular versions)

11) Claisen condensation (intra and intermolecular versions)

12) Michael addition

13) Robinson annulation

Practice arrow pushing mechanism for the following reactions

Practice arrow pushing mechanism for the following reactions

1) Reaction of enolates with alkyl halides

2) Aldol condensation (intra and intermolecular versions)

3) Claisen condensation (intra and intermolecular versions)

4) Michael addition

5) Haloform reaction