Chapter 7: Linkage, Recombination, and Eukaryotic Gene Mapping

Independent assortment

What is the term for alleles of two different genes that are sorted independently of one another

Linkage

What is the term to describe genes on the same chromosome

Inherited together

Close genes on the same chromosome will be - -.

Unlikned

Describe the linkage of two genes that go through independent assortment

Fully linked

Describe the linkage of two genes that have no crossing over/ recombination between alleles

Incomplete link

Describe the linkage of two genes that have some crossing over/recombination between alleles

Half

How much of the progeny is recombinant in unlinked genes?

None

How many new genotypes are made in fully linked genes

Paternal configuration

In fully linked genes, gametes retain the - -

Only non recombinant progeny

What kind of progeny are produced in complete linkage?

Recombination

What term describes the separation of linked genes

Recombinant

Recombination frequency is (# of - progeny)/(total # of progeny)

50

What is the maximum amount of recombination frequency

Coupling cis

Name the allele configuration where the wild type alleles are found on one chromosome, and the mutant alleles are found on the other chromosome

Repulsion trans

Name the allele configuration where each chromosome has both a wildtype allele and a mutant allele

The most frequent gametes

How can you tell the parental configurations in a progeny

No crossing over

When a tetrad separates after meiosis ii and each gamete receives a non-recombinant chromosome with the original combination of alleles, that means - - - occurred

Crossing over

When a tetrad separates after meiosis ii and half the resulting games have nonrecombinant chromosomes and the other half has recombinant chromosomes means - - has occurred between non-sister chromatids

Unlinked

When there is equal frequency of the alleles produced in a cross that means the alleles are -

Linked

When there is a difference in distribution of the frequency of the alleles produced in a cross that means the alleles are -

Genetic map

What is the term to describe the application of chromosome maps calculated by using the genetic phenomenon of recombination

Physical map

What is the term to describe the application of chromosome maps calculated by using physical distances along the chromosome; often expressed as numbers of base pairs

Recombination frequency

Genetic maps are based on - -

The actual genetic sequence

Physical maps are based on - - - -

Which chromosome

There is limitations to the genetic map, in which the distance is not always accurate and it does not provide info about - - genes are located on

Multiple crossovers

Name a factor which causes the genetic map application to be inaccurate about the distance between genes

Double crossover

What type of crossover makes gametes that “look” non-recombinant

Short distances

Genetic maps are more accurate when theyre based on - -

Physical mapping

Somatic-cell hybridization, deletion mapping, and molecular analysis are methods used to determine gene positions on chromosomes in - -

Somatic cell hybridization

What type of physical mapping method use somatic cells from different cell lines to fuse by treating them with polyethylene glycol

Heterokaryons

Somatic cell hybridization can result in cells with two nuclei called -

Lose chromosomes randomly

In somatic cell hybridization, the cell divides and - - -

Homozygous recessive

A special cross in deletion mapping methods have a cross between a - - mutation x heterozygous with a known deletion

Molecular analysis

Using fluorescent dyes with gene specific probes on genes of interest is part of which physical mapping method