Hematopathology & Autoimmune Diseases

philadelphia chromosome is associated with

leukemia

diffuse, boggy(squishy), gingival swelling are all clinical features of

leukemia

multiple osteomas =

gardner syndrome

lymphoid hyperplasia is

reactive

punched out radiolucencies, teeth floating in air

langerhans’ cell histiocytosis

birbeck granules associated with

langerhan’s cell histiocytosis

reed sternberg cells associated with

hodgkin lymphoma

stage 1 of hodgkins lymphoma involves

a single lymph node or organ site

stage 2 of hodgkins lymphoma involves

2 or more lymph node involvement on same side of diaphragm 

stage 3 of hodgkins lymphoma involves

lymph node regions with dual diaphragm involvement

non-hodgkin lymphoma

malignancy of lymphocytes

non-hodgkin lymphoma arises from

B cells

associated with epstein barr virus (EBV)

burkitt lymphoma

pt who have multiple myeloma secrete high amount of protein products in the urine called 

bence-jones proteins

pt who have multiple myeloma are usually on 

bisphosphonates

multiple myeloma radiographic appearance

punched out

plasmacytoma may transform into

multiple myeloma

desquamative gingivitis is a clinic descriptor only 

true

if your pt has desquamative gingivitis what next

biopsy and place in formalin/michel’s solution

michel’s solution is used for

direct immunofluorescence

formalin

preserves dead tissue

michel’s solution

keeps tissue alive

direct immunofluorescence tests for

autoantibodies

lichen planus clinical appearance

lacey

Four P’s of lichen planus

purple, pruritus, polygonal, papules

skin lesions of lichen planus where

flexor surface of arms

symblepharons

ocular lesions

positive nikolsky sign

if vesicle forms after applied pressure on gingiva

positive nikolsky sign and semblepharons indicate

mucous membrane pemphigoid

histology shows epithelial clefting in 

mucous membrane pemphigoid

butterfly malar rash associated with 

lupus

acute GVHD occurs within

100 days of transplant

chronic GVHD occurs more than

100 days after transplant

what type of GVHD is more common

chronic