herpes viruses - virology exam

all herpes viruses

ds dna viruses, non-segmented, enveloped, chronic infection, human only

types of herpes viuses

alpha, beta, gamma

types of alpha viruses

hsv-1, hsv-2, vzv/chicken pox

types of beta viruses

cmv

types of gamma viruses

ebv, hhv-8

target cells of hsv-1

mucoepithelial cells (mainly facial, can be genital)

latency cell of hsv-1

neuron

transmission of hsv-1

contact with shedding mucoepithelial cells, does not require sores

does hsv-1 have viremia, a vaccine, or drugs that work

no, no, yes (prevents replication, does not clear infection)

target cell of hsv-2.

mucoepithelial cells (mainly facial, can be genital).

latency cell of hsv-2.

neuron.

transmission of hsv-2

contact with shedding mucoepithelial cells during sex, birth. does not require sores

does hsv-2 have viremia, a vaccine, or drugs that work.

no, no, yes (prevents replication, does not clear infection)

initial/secondary target cells of vzv

respiratory epithelilal cells/respiratory tract, skin

latency cell of vzv/reactivation

neuron/shingles

primary/secondary transmission of vzv

respiratory/contact with shedding from skin

does vzv have viremia, a vaccine, or drugs that work

yes, yes (live attenuated or recombinant), yes (prevents replication, does not clear infection)

age effect of vzv

worst infections in adults because they have stronger immune response

target cells of cmv

cells of immune system (monocytes, granulocytes, lymphocytes) and epithelial cells

latency cells of cmv

monocytes, myeloid stem cells, other

transmission of cmv

contact with blood bodily fluids, transplacental, breast feeding, organ transplant

does cmv have viremia, a vaccine, or drugs that work against it/

no, no, yes (prevents replication, does not clear infection)/

prevention of cmv

screening

target cells of ebv

b cells and epithelial cells

latency cells of ebv

b cells

primary/secondary transmission of ebv

saliva(kissing)/asymptomatic shedding

does ebv have viremia, a vaccine, or drugs that work against it

no, no, no

prevention of ebv

avoid contaminated saliva

what can ebv cause

major cause of mono, can transform cells into cancerous cells

target cells of hhv-8

lymphocytes

latency cells of hhv-8

b cells

primary/secondary transmission of hhv-8

saliva(kissing), genital fluids/asymptomatic shedding

does ebv have viremia, a vaccine, or drugs that work against it’

no, no, no’

prevention of hhv-8

avoid contaminated saliva, safe sex

what can hhv-8 cause

typically asymptomatic, kaposi sarcoma in immunocompromised