Immunology Exam 3- Hypersensitivity Comparison Chart

How many hypersensitivity reactions are there?

4

What types of hypersensitivity reactions involve antibodies?

1, 2, 3

What type of hypersensitivity reaction involves T cytotoxic cells?

4

What is hypersensitivity?

immunological reaction that may result in a damaging excessive overreaction following secondary exposure to antigen

What antibody is associated with type I reactions?

IgE

What antibodies are associated with type II reactions?

IgG and IgM

What antibodies are associated with type III reactions?

IgG and IgM

What antibodies are associated with type IV reactions?

none

What antigen is associated with type I reactions?

exogenous antigens

Define exogenous

originating from outside an organism

What antigen is associated with type II reactions?

cell surface

What antigen is associated with type III reactions?

soluble

What antigen is associated with type IV reactions?

cellular

What is the response time for type I reactions?

15-30 minutes

What is the response time for type II reactions?

minutes to hours

What is the response time for type III reactions?

3-8 hours

What is the response time for type IV reactions?

48-72 hours or longer

What is the appearance of type I reactions?

weal and flare

What is the appearance of type II reactions?

lysis and necrosis

What is the appearance of type III reactions?

erythema (reddening) and edema

What is the appearance of type IV reactions?

erythema and induration (thickening and hardening of soft tissue)

What is the histology of type I reactions?

basophils and eosinophils

What is the histology of type II reactions?

AB and complement

What is the histology of type III reactions?

PMN and complement

What is the histology of type IV reactions?

monocytes and lymphocytes

What reactions are transferred with antibody?

Type I, II, III

How are type IV reactions transferred?

T-cells

What are examples of type I reactions?

hay fever and asthma

What are examples of type II reactions?

pemphigus (blistering of skin/cavities) and good pasture (produce antibodies that attack the lungs and kidneys)

What are examples of type III reactions?

farmer’s lung and SLE (lupus)

What are examples of type IV reactions?

TB test, poison ivy, granuloma