How many hypersensitivity reactions are there?
4
What types of hypersensitivity reactions involve antibodies?
1, 2, 3
What type of hypersensitivity reaction involves T cytotoxic cells?
4
What is hypersensitivity?
immunological reaction that may result in a damaging excessive overreaction following secondary exposure to antigen
What antibody is associated with type I reactions?
IgE
What antibodies are associated with type II reactions?
IgG and IgM
What antibodies are associated with type III reactions?
IgG and IgM
What antibodies are associated with type IV reactions?
none
What antigen is associated with type I reactions?
exogenous antigens
Define exogenous
originating from outside an organism
What antigen is associated with type II reactions?
cell surface
What antigen is associated with type III reactions?
soluble
What antigen is associated with type IV reactions?
cellular
What is the response time for type I reactions?
15-30 minutes
What is the response time for type II reactions?
minutes to hours
What is the response time for type III reactions?
3-8 hours
What is the response time for type IV reactions?
48-72 hours or longer
What is the appearance of type I reactions?
weal and flare
What is the appearance of type II reactions?
lysis and necrosis
What is the appearance of type III reactions?
erythema (reddening) and edema
What is the appearance of type IV reactions?
erythema and induration (thickening and hardening of soft tissue)
What is the histology of type I reactions?
basophils and eosinophils
What is the histology of type II reactions?
AB and complement
What is the histology of type III reactions?
PMN and complement
What is the histology of type IV reactions?
monocytes and lymphocytes
What reactions are transferred with antibody?
Type I, II, III
How are type IV reactions transferred?
T-cells
What are examples of type I reactions?
hay fever and asthma
What are examples of type II reactions?
pemphigus (blistering of skin/cavities) and good pasture (produce antibodies that attack the lungs and kidneys)
What are examples of type III reactions?
farmer’s lung and SLE (lupus)
What are examples of type IV reactions?
TB test, poison ivy, granuloma