🔹 BIOLOGICAL AETIOLOGIES

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Last updated 2:48 AM on 3/24/26
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8 Terms

1
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What is genetic vulnerability in depression?

Inherited genes that increase the risk of developing depression

2
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How do twin studies support genetics in depression?

Higher concordance in MZ twins (100%) than DZ twins (50%) suggests genetic influence

3
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What is gene × environment interaction?

Depression occurs when genetic risk combines with stressful life events

4
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What does the serotonin hypothesis state?

Low serotonin levels are linked to depression

5
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What are SSRIs?

Antidepressants that increase serotonin levels

6
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What is bidirectional ambiguity?

It is unclear whether low serotonin causes depression or results from it

7
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Kendler et al. (2006)

Twin study showing higher concordance in MZ twins → genetic influence

8
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Caspi et al. (2003)

Gene (5-HTT) + stress increases risk of depression

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