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What is genetic vulnerability in depression?
Inherited genes that increase the risk of developing depression
How do twin studies support genetics in depression?
Higher concordance in MZ twins (100%) than DZ twins (50%) suggests genetic influence
What is gene × environment interaction?
Depression occurs when genetic risk combines with stressful life events
What does the serotonin hypothesis state?
Low serotonin levels are linked to depression
What are SSRIs?
Antidepressants that increase serotonin levels
What is bidirectional ambiguity?
It is unclear whether low serotonin causes depression or results from it
Kendler et al. (2006)
Twin study showing higher concordance in MZ twins → genetic influence
Caspi et al. (2003)
Gene (5-HTT) + stress increases risk of depression