The citric acid cycle

PDH kinase

turns off PDH

PDH phosphatase

turns on PDH

Inhibitor of PDH kinase

works on PDH kinase

ADP and pyruvate

goal: leave PDH on to run the TCA

activators of PDH kinase

acetyl-coA and NADH
works on PDH kinase

goal: want to turn off the PDH in order to prevent the build up of themselves and stop use of glucose

activator of PDH phosphate

Ca2+, want to leave on the PDH to run TCA in order to make ATP

FA synthesis

connected to TCA via citrate

Gluconeogenesis

connected to TCA via malate

a ketogluterate

Can make amino acids and neurotransmitters

Can be made by glutamate and GABA

Oxaloacetate

can exit the TCA to make amino acids

alanine

alternate source of pyruvate

an amino acid

palmitate

alternate source of pyruvate

a fatty acid

acetoacetate

alternate source of pyruvate

a ketone body

GTP

regulates TCA by controlling the amount of succinyl coA turning into succinate