antifungal agents

prototype polyene antibiotic

prototype polyene antibiotic

ampho b

ampho b binds to the ___ component of the cell membrane

ergosterol

ampho is highly ___

toxic

ampho is toxic because it binds to ___ in humans

cholesterol

two adverse effects seen in all for ampho b

infusion reaction and renal damage

infusion reactions for ampho b begin ___ hours after start

1-3

pretreat ampho b infusion rxns with what two drugs

benadryl and tylenol

avoid what drug with ampho b

aspirin

iv ampho b has a high incidence of ___

phlebitis

nephrotoxicity for ampho b is related to ___

dose

ampho b does not cross into ____

csf

azoles can be taken ____

PO

azoles inhibit which enzyme

P450

azoles can lower _____ to suppress cardiac

ventricular EF

azoles interact with any drugs that raise ___

pH

alternative to ampho b that is oral and less toxic

ketoconazole

ampho b also causes ___ suppression

bone marrow

two things to monitor for anemia

CBC and s/s

infusion time for ampho b

2-4 hours

flucytosine treats which two strains

candida or cryptococcus

griseofulvin is deposited into ____

keratin

griseofulvin should be taken with ___ to increase absorption

fatty foods

griseofulvin does not work against ___

candidiasis