Pharm Exam 1 Concept: PNS, Cholinergic, Anticholinergic

Functions of the PNS

Slowing of the HR

Increased gastric secretions

Emptying of the bladder

Emptying of the bowel

Focus eye for near vision

Constrict pupil

Contract bronchial smooth muscle

Reducing cardiac work load

Rest and Digest

Cholinergic / Cholinergic Agonist =

Parasympathomimetic

Functions of the PNS

Slowing of the HR

Increased gastric secretions

Emptying of the bladder

Emptying of the bowel

Focus eye for near vision

Constrict pupil

Contract bronchial smooth muscle

Reducing cardiac work load

Rest and Digest

Cholinergic / Cholinergic Agonist =

Parasympathomimetic

Anticholinergic / Cholinergic Antagonist

Parasympatholytic

PNS Neurotransmitter =

Acetylcholine

PNS Receptors

nicotinic and muscarinic

Muscarinic functions

Smooth contraction (airway, iris, bladder)

Cardiac Contractions decreased

Salivary gland activity

Nicotinic Functions

Found at neuromuscular junctions

Primary receptor for nerve-muscle communication for muscle contraction

Regulate the inflammatory process in the immune system

Cholinergic Agonist

Increase detrusor muscle tone

Used for post op urinary retention

Urecholine (bethanechol)

Indirect-acting Cholinergic Agonist

Used for Myasthenia Gravis

Pyridostigmine (Mestinon)

Nursing Considerations for Pyridostigmine

Respiratory status, personal hx, administer throughout the day, psychogenic effects

Cholinergic Antagonist

Blocks cholinergic receptors

Used for symptomatic brady, cholinergic antidote

Atropine

ANS functions

Regulates the heart, regulates secretory glands, regulates smooth muscle, SNS an PNS, and sweat glands innervate from SNS