EHEC, EPEC AND UPEC

Clinical futures EHEC

- Watery diarrhoea
- Haemorrhagic
colitis
- Haemolytic
uremic syndrome

Clinical futures EPEC

- Water diarrhoea
- Vomiting

Clinical futures UPEC

- Cystitis
- Pyelonephritis

Virulence factors EHEC

- Shiga toxins
- Attaching and effacing = exotoxin

Virulence factors EPEC

- Bundle-forming pili
- Attaching and effacing = adherence factor

Virulence factors UPEC

- Adhesins (P pili, AAF/I, AAF/III, Dr)
- Haemolysing
- Pathogenicity islands = adherence factor

Trimethoprim, Sulfamethoxazole,
fluoroquinolones

Treatment UPEC

Epidemiologic features EHEC

Food-born, water-born outbreaks in developed countries

Epidemiologic features EPEC

Infants in developing countries

Epidemiologic features UPEC

Sexually active woman