4 - Dose-Response Curves

a. increases

1. When the dose-response curve shifts to the right, the dose

   a. increases

   b. decreases

b. Quantal dose response curve

2. All or non-dose response curve

   a. Graded dose response-curve

   b. Quantal dose response curve

a. Therapeutic index

3. The ratio of LD50 and ED50

   a, Therapeutic index

   b. Therapeutic window

   c. DOA

   d. Therapeutic classification

b. The dose of Drug B is greater than Drug A to provide similar effect

4. Drug A is more potent than drug B. This means

   a. The dose of Drug A is greater than Drug B to provide similar effect

   b. The dose of Drug B is greater than Drug A to provide similar effect

   c.The dose of Drug B is similar is to the Drug A since they have the same efficacy

   d. AOTA

b. Partial agonist becomes an antagonist

6. Full agonist + Partial agonist

   a. Full agonist becomes an antagonist

   b. Partial agonist becomes an antagonist

   c. Partial agonist becomes a full agonist

   d. Full agonist becomes an inverse agonist

a. the lower the potency

7. The higher the dose

   a. the lower the potency

   b. the lower the efficacy

   c. The greather the safety

   d. the higher the potency

Coma

ingestion of 10mg of Atropine can lead to

Graded Dose-Responsive Curve

• Involves one patient only

• Assesses safety

• Relationship between dose & magnitude or intensity of effect

• Continuous scale

Potency

Dose required to produce 50% effect

Right shift

↓ potency = ___ shift

Left shift

↑ potency = ___ shift

↑potency

↓ dose = ___ potency

Ceiling Dose

• safety of the drug

• minimal dose that produces maximal (100%) response

Ceiling effect

dose beyond which there is no additional effect

Full Agonist + Competitive Antagonist

• “Parallel”

• Potency:  ↓ (right shift)

• Efficacy: same

Full Agonist + Non-competitive Antagonist

• “Anti-Parallel”

• Potency:  ↓ (right shift)

• Efficacy: ↓ (down shift)

Full Agonist + Partial Agonist

• Potency:  ↓, ↑, same

• Efficacy: ↓ (down shift)

Quantal Dose-Response Curve

• Involves many patients

• Relationship between DOSE & frequency of effect

• Aka ALL or NONE

Therapeutic Index

Measure of drug’s relative safety

Therapeutic Window

• Measure of drug’s clinical safety

• Dosage range at which a drug is BOTH safe & effective

Formula for Therapeutic Index

Unsafe

narrow therapeutic index means what?

1000 → 50 → 10 → 0.1

Rank from the safest to unsafe therapeutic index

0.1, 10, 50, 1000

the higher the safety profiles

The higher the Therapeutic Index, the ___ safety profile

Safe and Effective

drugs should be both __ & __