Lecture 3b: Acid dissociation constant (pKa)

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9 Terms

1
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What does pKa measure?

The acid strength of a substance (how easily it donates a proton)

2
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What does a low pKa indicate?

A strong acid — more likely to donate a proton.

3
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What does a high pKa indicate?

A weak acid — less likely to donate a proton.

4
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What is the relationship between base strength and the pKa of its conjugate acid?

  • Strong base → weak conjugate acidhigh pKa

  • Weak base → strong conjugate acidlow pKa

5
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Why does a strong base have a high pKa?

Because its conjugate acid is very weak and does not easily donate a proton.

6
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Why does a weak base have a low pKa?

Its conjugate acid is stronger and donates a proton more readily.

7
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What is an amphoteric compound?

A substance that can act as both an acid and a base depending on the environment.

8
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What structural feature makes a molecule amphoteric?

The presence of both acidic and basic functional groups

9
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How do amphoteric compounds behave with strong acids and strong bases?

  • With strong acids → act as a base

  • With strong bases → act as an acid