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main driver that favors annealing (enthalpic)
base stacking
favors annealing (enthalpic)
H-bonds of base pairing
favors annealing (entropic)
water freed from clathrates around hydrophobic portions of bases
favors melting (enthalpic)
increased bonds between water and bases
favors melting (enthalpic) (2)
relief of cross strand double negative interactions
favors melting (entropic)
increased freedom of individual strands