HIV NNRTI/Protease Inhibitors Key Facts

All NNRTI Side Effects

• hepatoxicity

• rash/SJS/TEN

• major CYP3A4 substrates

Efavirenz

• psychiatric symptoms (depression/suicide)

• CNS effects

• increase in total cholesterol and triglycerides

• food increases bioavailability - take on empty stomach

Rilpivirine (Edurant)

• component of Complera, Odefsey, Cabenuva

• Take oral formulation with meal and water, requires acidic environment for absorption - don’t use with PPIs, separate H2RA/antacids

• depression

• increases SCr with no effect on GFR

• do not use if initial viral load > 100k or CD4 count < 200

• injection site reactions for Cabenuva

All Protease Inhibitors Side Effects

• TAKE WITH BOOSTER

• no renal dose adjustments

• metabolic abnormalities - hyperglycemia/dyslipidemia

• hepatic dysfunction

• hypersensitivity reactions - rash, angioedema

• diarrhea, nausea

• strong CYP inhibitors, CYP3A4 inducers decrease concentration

Atazanavir (Reyataz)

• component of Evotaz

• needs acidic environment - separate H2RAs, avoid PPIs

• take with food

• hyperbilirubinemia - reversible

Darunavir (Prezista)

• component of Symtuza

• take with food

• sulfa allergy