Chemotherapy, Immunosuppressants, and ESAs

Doxorubicin

N/A

Chemotherapy

Cyclophosphamide

N/A

Chemotherapy

Carboplatin

N/A

Chemotherapy

Docetaxel

Taxotere

Chemotherapy

Paclitaxel

Taxol

Chemotherapy

Tacrolimus

Prograf

Immunosuppressant

Cyclosporine

Neoral

Immunosuppressant

Darbepoetin alfa

Aranesp

Erythropoeisis-stimulating agent

Epoetin alfa

Epogen, Procrit

Erythropoeisis-stimulating agent

Important interactions with chemotherapy drugs?

-Live vaccines create infection risk

-Excessive effect with other immunosuppressants

Side effects of chemotherapy drugs? ________, ________, _______

-Alopecia (hair loss)

-Nausea

-Organ toxicity

-Neutropenia (death of WBCs)

Indication for erythropoeisis-stimulating agents?

Low-RBC anemia

Side effects of erythopoeisis-stimulating agents?

-Thromboembolism

-Tumor growth

Interaction with erythropoeisis-stimulating drugs?

-Other clot risk drugs (estrogen)

Indications for an immunosuppressant?

-Prevent organ transplant rejection

-Autoimmune disorders

Side effects of immunosuppressants?

-Nephrotoxicity

-Infection risk