Role of IP3 in signal transduction
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What does PLC-γ do in T-cell signal transduction?
PLC-γ cleaves phosphatidylinositol bisphosphate into inositol triphosphate (IP3) and diacylglycerol (DAG).
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What is the effect of IP3 in T-cell signaling?
IP3 triggers calcium channels to open, allowing calcium ions to flow in.
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What role do calcium ions play in T-cell activation?
Calcium ions activate calcineurin, a phosphatase.
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How does calcineurin affect NFAT?
Calcineurin dephosphorylates NFAT, allowing it to relocate to the nucleus.
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What happens after NFAT relocates to the nucleus?
NFAT activates genes involved in T-cell expansion and differentiation.
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