Diffusion of Na+ ions and actions of Na+ K+ pump

How does Na+ influence resting membrane potential (RMP)?

Na+ leaks into the cell down its concentration gradient, making the inside slightly more positive.

What is the role of the Na+-K+ pump in maintaining RMP?

It continuously compensates for the leakage of both K+ and Na+, helping maintain a negative charge inside the cell.

What are the three major factors that contribute to the resting membrane potential (-70 mV)?

1. K+ diffusion out of the cell.
2. Na+ diffusion into the cell.
3. The actions of the Na+-K+ pump.

Despite some diffusion, where is Na+ more concentrated?

Outside the cell.

Despite some diffusion, where is K+ more concentrated?

Inside the cell.