BBW + Contraindications

Alendronate

Esophageal abnormalities

Hypocalcemia

Inability to sit or stand upright for at least 30 min

Increased risk for adverse esophageal effects

Anastrozole

Pregnancy

Apixaban

BBW - Premature discontinuation increases risk of thrombotic events; increased risk of spinal hematoma with spinal puncture or neuraxial anesthesia

Contraindications - Hypersensitivity, active bleeding

Conjugated Estrogen

Breast cancer, cardiovascular disease, endometrial cancer, dementia risks

Undiagnosed abnormal genital bleeding

History of estrogen- or progesterone-dependent neoplasia Active or history of DVT or PE

Severe liver dysfunction

Known or suspected pregnancy

Cyanocobalamin

Hypersensitivity to cyanocobalamin or cobalt

Darifenacin

Gastric retention

Glaucoma Urinary retention

Dicyclomine

Age <6 months

Breastfeeding

GI obstruction

Glaucoma

Myasthenia gravis

Obstructive uropathy

Reflux esophagitis

Severe ulcerative colitis

Toxic megacolon

Unstable cardiovascular state in acute hemorrhage

Dutasteride

Pregnancy

Use in children

Estradiol Oral

Endometrial and breast cancer risk, dementia risk; should not be used to reduce CV risk; secondary exposure risk (transdermal solution)

History of thromboembolic disorders

Breast cancer

Any estrogen-dependent neoplasm

Known or suspected pregnancy

Estradiol Transdermal Patch

Endometrial and breast cancer risk, dementia risk; should not be used to reduce CV risk; secondary exposure risk (transdermal solution)

History of thromboembolic disorders

Breast cancer

Any estrogen-dependent neoplasm

Pregnancy

Ethinyl Estradiol/Etonogestrel Ring

Smoking risk

History of thromboembolic disorders

Endometrial cancer

Uncontrolled

HTN

Pregnancy

Smoking ≥15 cigarettes per day and >35 years of age

Finasteride

Pregnancy

Use in children

Ibandronate

Esophageal abnormalities, which delay esophageal emptying

Hypocalcemia

Inability to sit or stand upright for at least 60 minutes

Medroxyprogesterone Oral

Cardiovascular, dementia risk, loss of BMD (Depo-Provera); breast cancer

Abnormal genital bleeding

History of estrogen- or progesterone-dependent neoplasia

Active or history of DVT or PE

Severe liver dysfunction

Known or suspected pregnancy

Methylprednisolone Oral

Administration of live vaccines

Fungal infections

Mirabegron

Hypersensitivity

Oxybutynin

Gastric retention

Glaucoma

Urinary retention

Progesterone

Cardiovascular disorders, breast cancer, dementia risk, risk versus benefits

Abnormal vaginal bleeding

History of estrogen- or progesterone-dependent neoplasia

Active or history of DVT or PE

Known or suspected pregnancy (oral only)

Raloxifene

Venous thromboembolism, stroke

Pregnancy or lactation

Current or history of thromboembolic disorders

Risedronate

Esophageal abnormalities that delay esophageal emptying

Hypocalcemia

Inability to sit or stand upright for at least 30 minutes

Sildenafil

Concurrent nitrates

Concurrent HIV protease inhibitors when used for treating pulmonary HTN

Concurrent guanylate cyclase stimulators

Tadalafil

Concurrent nitrates

Concurrent guanylate cyclase stimulators

Tamsulosin

Hypersensitivity

Testosterone

Secondary exposure

Men with breast or prostate cancer

Women who are pregnant, who may become pregnant, or who are breast-feeding

Tolterodine

Gastric retention

Uncontrolled narrow-angle glaucoma

Urinary retention