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139 Terms
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The Science of Nutrition
the study of the nutrients and other substances in foods and how the body handles them
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Animal Nutrition
Animal nutrition includes the processes by which food is Ingested, digested, and absorbed into body cells and fluids
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Ingestion
the feeding method used to take food into the digestive cavity
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Digestion
splitting of carbohydrates, proteins, lipids, and nucleic acids in foods into chemical subunits small enough to be absorbed into an animal’s body fluids and cells
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Absorption
movement of organic molecules, electrolytes (inorganic ions), vitamins, and water across the digestive epithelium and into the interstitial fluid of the digestive tract
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Herbivores
such as antelopes, horses, bison, giraffes, kangaroos, manatees, and grasshoppers obtain organic molecules primarily by eating plants (plant-eating)
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Carnivores
such as cats, tasmaniandevils, penguins, sharks, and spiders, primarily eat other animals (meat-eating)
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\n Omnivores
such as crows, cockroaches, and humans, eat both plants and animals and, with appropriate digestive enzymes, may consume any source of organic matter
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calorie
amount of energy required to raise the temperature of 1.0g of pure water by 1°C
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kilocalorie
\[1 kcal = 4.2 kilojoules\] equals 1,000 calories or one Calorie(capital C)
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Nutrients
Chemical substances obtained from food and used in the body to provide energy, structural materials, and regulating agents to support growth, maintenance, and repair of the body’s tissues
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Simple inorganic nutrients ( Do not contain carbon)
Minerals : Each mineral is a chemical element; its atoms are all alike.▪E.g., Calcium, magnesium, zinc, iron, potassium etc.
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Complex organic nutrients
Carbohydrates, lipids, proteins, and vitamins▪In addition to hydrogen and oxygen, they all contain carbon, an element found in all living things▪They are therefore called organic▪Protein and some vitamins also contain nitrogen and may contain other elements as well
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Malnutrition
Malnutrition refers to deficiencies, excesses, or imbalances in a person’s intake of energy and/or nutrients
\ The term malnutrition addresses 3 broad groups of conditions:
**Undernutrition**, which includes wasting (low weight-for-height), stunting (low height-for-age) and underweight (low weight-for-age)
**Micronutrient-related malnutrition**, which includes micronutrient deficiencies (a lack of important vitamins and minerals) or micronutrient excess
**Overweight, obesity and diet-related noncommunicable diseases** (such as heart disease, stroke, diabetes and some cancers)
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Essential Nutrients
Essential amino acids, fatty acids, vitamins, and minerals are known collectively as an animal’s essential nutrients
Organic molecules serve as building blocks for carbohydrates, lipids, proteins, and nucleic acids. Animals synthesize many organic molecules –however, they cannot make certain **essential amino acids** and **essential fatty acids**, which must be obtained in the diet
Example: in the absence of essential amino acids in the diet, an animal would have to break down its own proteins to provide amino acids for new protein synthesis
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Vitamins
are organic molecules required in small quantities that the animal cannot synthesize for itself –many are coenzymes, nonprotein organic subunits that assist in enzymatic catalysis
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\n Essential minerals
required inorganic elements such as calcium, iron, and magnesium
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\n Undernutrition
An animal suffering from undernutrition is starving for one or more nutrients –**taking in fewer calories than needed for daily activities**
Animals with chronic undernutrition lose weight because they have to use energy-providing molecules of their own bodies as fuels.
Mammals use stored fats and glycogen first, then proteins.
Use of proteins as fuel leads to muscle wastage and, in the long term, organ and brain damage, which leads to death
\ form of malnutrition, a condition resulting from an improper diet. Undernutrition is defined as insufficient intake of energy and nutrients to meet an individual’s needs to maintain good health. Socioeconomic and geopolitical factors (availability and supply) can result in undernutrition
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Overnutrition
form of malnutrition (imbalanced nutrition) arising from excessive intake of nutrients, leading to accumulation of body fat that impairs health. Over time, regular intakes in excess of needs may also have adverse effects
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Amino acids that cannot be synthesized by the human body, but that have to be supplied in their diet are called ______________. \*\*\*slide question
essential amino acids
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Fluid feeders
ingest liquids that contain organic molecules in solution \[E.g., Mosquitoes (feed on blood), hummingbirds (feed on nectar)
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Suspension feeders
ingest small organisms that are suspended in water (E.g., Clams, baleen whales)
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Deposit feeders
ingest particles of organic matter from solid material they live in or on (E.g., Earthworms, crabs)
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Bulk feeders
consume sizeable food items whole or in large chunks (most adult mammals, reptiles, birds, amphibians)
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Based on how they obtain food nutrients, mammals belong to the category of ___________. \*\*\*slide question
bulk feeders
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Digestive Processes
Digestive processes break food molecules into molecular subunits(an absorbable form), that can be absorbed into body fluids and cells.
Breakdown occurs by enzymatic hydrolysis, in which chemical bonds are broken by the addition of H+and OH.
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Amylases
hydrolyze starches
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lipases
a pancreatic enzyme, hydrolyzes the fats in micelles into monoglycerides and free fatty acids
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proteases
hydrolyze proteins
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nucleases
hydrolyze nucleic acids
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Intracellular Digestion
Sponges and some cnidarians break down food exclusively by intracellular digestion.
\ Cells take in food particles (organic material and microorganisms) by endocytosis through pores in body wall of animal’s sac-like body. An endocytic vesicle containing food particles fuses with a lysosome containing hydrolytic enzymes (forming endolysosomes). Molecular subunits produced by hydrolysis pass from the vesicle to the cytosol. Undigested material remaining in the vesicle is released to the outside of the cell by exocytosis
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Intracellular Digestion (Choanocytes in sponges)
Inside the body cavity, specialized cells called choanocytesor collar cells line the body wall.
Choanocytes trap food particles, take them in by endocytosis and transport them to amoeboid cells which digest the particles intracellularly.
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The specialized cells called choanocytes are present in the body walls of sponges which trap food ingested through the pores in their body walls. True or False?
True
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Extracellular Digestion
Most invertebrates and all vertebrates digest food primarily by extracellular digestion –outside body cells, in a pouch or tube that is enclosed within the body.
Specialized compartments prevent the animal from digesting its own body tissues.
Epithelial cells secrete enzymes that digest the food. Extracellular digestion greatly expands the range of available food sources, and allows animals to eat large batches of food.
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Digestive Tubes
Most invertebrates and all vertebrates have a tubular digestive tract system with two openings - the digestive contents move in one direction, from the mouth (proximally and anteriorly) to the anus (distally)
\ The inside of the digestive tube (**lumen**) is functionally external to all body tissues, because they open to external environment (outside of the body)
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Five Steps in Digestion
Mechanical processing: Mastication
Secretion of enzymes and other digestive aids
Enzymatic hydrolysis
Absorption
Elimination
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Mechanical processing: Mastication
Chewing, grinding, and tearing food chunks into smaller pieces increases their mobility and the surface area exposed to digestive enzymes
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Secretion of enzymes and other digestive aids
Release of enzymes and other substances that aid the process of digestion, such as acids, emulsifiers, and lubricating mucus, into the tube
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**Enzymatic hydrolysis**
Food molecules are broken down through enzyme-catalyzed reactions into absorbable molecular subunits
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Absorption
The molecular subunits are absorbed from the digestive contents into body fluids and cells
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Elimination
Undigested materials are expelled through the anus
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Digestion In An Annelid
The earthworm is a deposit feeder that feeds on organic soil particles
Muscular activity moves particles through the esophagus into the crop, where they are stored and mixed with mucus.
This mixture enters the gizzard, which contains grains of sand, and is ground into fine particles (mechanical processing of food)
The mixture enters a long intestine, Organic matter is hydrolyzed by enzymes, Muscular contractions move the mixture along, Cells lining the intestine absorb molecular subunits
Undigested residue is expelled through the anus
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The organ which is involved in mechanical processing of food in annelids such as earth worm is _____________. \*\*\*\*slide question
gizzard
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Digestion In An Insect
Herbivorous insects such as the grasshopper tear plant parts into small particles with hard external mouth parts :
Salivary secretions in the pharynx begin digestion
Food moves through the esophagus, crop, and gizzard to the stomach.
In the stomach, the food is hydrolyzed by enzymes in gastric ceca –products are absorbed through walls of the ceca
Undigested contents move to the intestine for further digestion and absorption
At the end of the intestine, water is absorbed, and remnants are expelled through the anus
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Digestion In A Bird
A pigeon picks up seeds and swallows them whole :
Seeds are moistened by mucus-filled saliva in the mouth
Seeds pass through the pharynxand tube-like anterior end of the esophagusto the pouch-like crop, which stores food
The glandular anterior portion of the stomach (**proventriculus**) secretes digestive enzymes and acids
Seeds are ground up in the posterior end (gizzard)
In the intestine, the liver secretes bile, and the pancreas adds digestive enzymes
Products are absorbed, and undigested residues are expelled through the anus
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Digestion In Humans And Other Mammals \*\*\*\*KNOW FIGURE REALLY WELL ON EXAM
The mammalian digestive system is a series of specialized digestive regions under control of the nervous and endocrine systems
The digestive system consists of a muscular tube
The digestive tract, also called the gastrointestinal (GI) tract or alimentary canal
The mouth, pharynx, esophagus, stomach, small and large intestines, rectum, and anus
Various accessory organs: Accessory organs include the salivary glands, teeth, tongue, pancreas, liver, and gallbladder. The glandular organs secrete their products into ducts that empty into the digestive tract.
The digestive system is not identical in all mammals – Specific adaptations have produced variations such as the digestive system of ruminants
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Refer to the figure below and match the correct structures labeled in the figure in the right hand column (represented by numbers from 1 to 10) with their appropriate functions in the left hand column.\[Please note that the numbers in the right most column represent the labels in the figure and taking this into consideration, select the correct choice A, B, C D, etc.\].
1\. Mouth (Oral cavity) - muscular tube , the contraction of which pushes the food to the stomach
2\. Pharynx - muscular contractions move food to esophagus by swallowing reflex
3\. esophagus - muscular moistened tube moves food from pharynx to stomach
4\. stomach - muscular sac; stretches to store food; secretes mucus/gastric juice that contains pepsinogen the precursor to pepsin and HCl
5\. small intestine - duodenum (first seg of small intestine) recieves secretions and produces enzymes that complete digestion of proteins, carbs, nucleic acid. absorbs nutrients.
6\. large intestine - absorbs water/mineral ions; secretes mucus/bicarbonate ions; make feces
7\. Pancreas - Secretes bicarbonate ions and absorbs water and other ions
8\. Gallbladder - stores and concentrates bile secreted by the liver
There are eight essential amino acids for adult humans:
lysine, tryptophan, phenylalanine, threonine, valine, methionine, leucine, and isoleucine –
infants and young children also require histidine
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Two fatty acids, are essential in the human diet \*\*\*KNOW SPELLING
linoleic acid and linolenic acid.
Both are required for synthesis of phospholipids that form parts of biological membranes and certain hormones. Almost all foods contain these fatty acids –however, people on a low-fat diet that is deficient in linoleic acid and linolenic acid are at serious **risk for developing coronary heart disease**
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Vitamins fall into two classes:
Water-soluble (hydrophilic) vitamins and Fat-soluble (hydrophobic) vitamins
The body stores fat-soluble vitamins in adipose tissues
Vitamin D differs from other vitamins because humans can synthesize it in the skin when exposed to ultraviolet light
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Vitamin D Synthesis and Activation \*\*\*\*KNOW DIAGRAM
In response to ultraviolet radiation of the skin, a photochemical cleavage results in the formation of vitamin D from 7-dehydrocholesterol
Vitamin D enters the circulation, whether absorbed from the intestine or synthesized cutaneously, bound to vitamin D–binding protein, an α-globulin synthesized in the liver
Vitamin D is subsequently 25-hydroxylated in the **liver** by a cytochrome P450 oxidase in the mitochondria and microsomes
The second hydroxylation, required for the formation of the mature hormone, occurs in the **kidney.**
The 25-hydroxyvitamin D-1α-hydroxylase converts 25-hydroxy vitamin D to 1,25(OH)2D **(calcitriol)**
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vitamin K
Required for making blood-clotting factors in the liver
Humans cannot make vitamin K, but much of the requirement is supplied by bacterial activity in the large intestine
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In Name the 4 fat-soluble vitamins. \*\*\*slide question
Vitamin A, D, E and K
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Vitamin A (retinol) \*\*\*KNOW REALLY WELL (FAT SOLUBLE)
common sources: Liver; fish oils; milk; eggs. (Beta-carotene, which is converted to vitamin A in the body, is in many plant foods such as sweet potato, spinach, and carrots.)
\ main function: **Component of visual pigments**; bone metabolism; epithelial tissue maintenance
\ selected effects of chronic deficiency: Night blindness; total blindness; skin disorders; decreased immunity
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Vitamin D \*\*\*KNOW REALLY WELL (FAT-SOLUBLE)
common sources: Fish liver oil; egg yolk; fortified milk; produced in skin exposed to sunshine
\ main function: Calcium and phosphorus absorption from gut
\ selected effects of chronic deficiency: Bone deformities (rickets) in children; bone softening in adults
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Vitamin E (tocopherol) \*\*\*\*KNOW REALLY WELL (FAT-SOLUBLE)
common sources: Nuts; seeds; vegetable oils
\ main function: Antioxidant; maintenance of cell Membranes
\ selected effects of chronic deficiency: Neuromuscular problems
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Vitamin K \*\*\*KNOW REALLY WELL (FAT-SOLUBLE)
common sources: Intestinal bacteria; green vegetables
\ main function: **Promotes synthesis of blood-clotting protein by liver**
\ selected effects of chronic deficiency: Abnormal blood clotting, bleeding
\
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vitamin B1 (thiamin) - water soluble \*\*KNOW REALLY WELL
common sources: Yeast; cereal grains; beans; nuts; meat
\ main function: Connective tissue formation; needed for folate utilization; coenzyme forming part of enzyme in oxidative reactions
\ selected effects of chronic deficiency: Beriberi (nervous system disorder that includes impaired sensory perception, limb weakness and pain, weight loss, cardiovascular malfunction)
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vitamin B2 - (riboflavin) - water soluble \*\*\*KNOW REALLY WELL
common sources: Fruits and vegetables; nuts; grains; meats
\ main function: Coenzyme of oxidative phosphorylation
\ selected effects of chronic deficiency: Pellagra (diarrhea, dermatitis, dementia)
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pantothenic acid (water soluble) \*\*\*\*KNOW REALLY WELL
common sources: In many foods (meat, yeast, egg yolk especially)
\ main function: Coenzyme in carbohydrate and fat oxidation; fatty acid and steroid synthesis
\ selected effects of chronic deficiency: Fatigue; tingling in hands; headaches; nausea
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\n The vitamin which is a component of the visual pigment in the photoreceptor cells in the eyes is ____________. \*\*\*\*slide question
Vitamin A or retinol
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The vitamin which is involved in the synthesis of blood clotting proteins in the liver is ____________. \*\*\*\*\*slide question
vitamin K
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Scurvy is a disease caused by the deficiency of _______________. \*\*\*slide question
Vitamin C
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Pick the two fat soluble vitamins from the options below. Choose the best option.
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A. Vitamin B6 and vitamin B12
B. Vitamin B1 and vitamin B2
C. Vitamin E and vitamin K
D. Vitamin B12 and ascorbic acid
E. Biotin and folic acid
F. Pantothenic acid and niacinamide
G. None of the above H. All of the above
C. Vitamin E and Vitamin K
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Macrominerals
required in large amounts (100 mg to more than 1 gram per day)
Calcium, phosphorus, magnesium, sodium, potassium, chloride, and sulfur
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\n Trace minerals
rerequired in small amounts (some less than 1 mg per day)
Iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium
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hypernatremia
too much sodium - elevated blood pressure
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hemochromatosis
excessive iron. Liver, heart, pancreas and blood vessel damage
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Potassium (K) \*\*\*\*KNOW REALLY WELL
common sources: Many vegetables and fruits; whole grains; dairy products
\ main function: Muscle and neural function; water balance; acid–base balance; main positive ion in cell
\ selected effects of chronic deficiency: Muscular weakness; cardiac abnormalities or failure
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Sodium (Na) \*\*\*KNOW REALLY WELL
common sources: Table salt; dairy products; eggs; meat
\ main function: Acid–base balance; water balance; muscle and neural function; main positive ion in extracellular fluid
\ selected effects of chronic deficiency: muscle cramps
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Sulfur (S) - \*\*\*KNOW REALLY WELL
common sources: Proteins from food sources, including legumes, nuts, dairy products, eggs, and meat
\ main function: Component of body proteins
\ selected effects of chronic deficiency: Same as protein deficiencies
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**Iodine (I)** - \*\*\*KNOW REALLY WELL
common sources: seafood; iodizes salt
\ main function: **thyroid hormone formation**
\ selected effects of chronic deficiency: Goiter (enlarged thyroid), with metabolic disorders
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**Iron (Fe)** \*\*\*\*KNOW REALLY WELL
common sources: Green leafy vegetables; legumes; whole grains; nuts; eggs; meats (particularly liver)
\ main function: Component of hemoglobin, myoglobin, and **electron Carriers in mitochondria**
\ selected effects of chronic deficiency: Iron-deficiency anemia;weakness
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Zinc (Zn) - \*\*\*\*KNOW REALLY WELL
common sources: Some vegetables; whole grains; legumes; nuts; fish; meats; many other foods
\ main function: Component of many enzymes and some transcription factors; protein synthesis; DNA synthesis; cell division; immunity; wound healing
\ selected effects of chronic deficiency: Impaired growth; loss of appetite; impaired immune function
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The mineral that is involved in thyroid hormone formation is ____________. \*\*\*slide question
Iodine
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The trace mineral that is a component of the electron carrier proteins in the mitochondria is __________________. \*\*\*slide question
A. Calcium(Ca)
B. Manganese(Mn)
C. Chloride (Cl)
D. Phosphorus (P)
E. Iron (Fe)
E. Iron (Fe)
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Mucosa
The inner lining, mucosa, which contains epithelial and glandular cells, lines the inside of the digestive tract. Contains epithelial and glandular cells.
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epithelial cells
Absorb digested nutrients, seal off the digestive contents from body fluids
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Glandular cells
Secrete enzymes, lubricating mucus that aids digestion, and substances that adjust the pH of the digestive contents
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submucosa
The submucosais a thick layer of elastic connective tissue that contains neuron networks (the enteric nervous system) and blood and lymph vessels
Neuron networks provide local control of digestive activity and carry signals between the gut and the central nervous system
Lymph vessels carry absorbed lipids to other parts of the body
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muscularis is formed by two smooth muscle layers
a circular and longitudinal layer
\ The stomach has an additional oblique layer running diagonally around its walls
These layers play an essential role in mechanical processing and in moving materials along the digestive tract
Contraction of circular muscles and relaxation of the longitudinal muscles lengthens the gut, and vice versa
these muscle produce **peristalsis**
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peristalsis
A wave of contractions that passes along the gut, constricting the gut and pushing the digestive contents onward
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1. Peristalsis consists of waves of muscular contractions that move a bolus 2. During a peristaltic movement, the circular muscles contract behind the bolus while circular muscles ahead of the bolus relax 3. Longitudinal muscles ahead of the bolus then contract, shortening adjacent segments 4. A wave of contraction in the circular muscles then forces the bolus forward
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Serosa
The outermost layer of the digestive tract
Consists of connective tissue that secretes a slippery fluid (serous fluid) that lubricates the areas between the digestive organs and other organs
continuous w the **mesentery**
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mesentery
a tissue that suspends the digestive system from the inner wall of the abdominal cavity
Attaches digestive organs to the abdominal wall
Supports the digestive organs while allowing them to move during contractions for mixing
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sphincters
Powerful rings of smooth muscle called sphincters form valves between major regions of the digestive tract
By contracting and relaxing, sphincters control the passage of digestive contents from one region to the next, and ultimately through the anus
Pharyngoesophageal sphincter
**Gastroesophageal sphincter**
Pyloric sphincter
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mouth
Teeth cut, tear, and crush food items into small pieces during mastication(chewing)
The food mass forms a bolus, a ball of chewed or liquid food, in preparation for swallowing
The enzyme responsible for digestion of complex starch in food is _____________. \*\*\*slide question
amylase
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Pharynx and esophagus
The swallowing reflexmoves the bolus into the pharynx
The epiglottis prevents food from entering the trachea
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The muscle that is weakened and due to which leads to the imperfect closure of the passageway to the movement of **bolus from the esophagus to the stomach, leading to acid reflux is** called ___________________. \*\*\*slide question
Gastroesophageal sphincter.
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stomach
The stomach –a large distensible sac, muscular elastic organ with the largest diameter of any part of the gastrointestinal tract
Located in the epigastrium, just inferior to the diaphragm
Extended “J” shape
\ 4 functions -
Storage of ingested food
Mechanical breakdown of ingested food
Disruption of chemical bonds in food through the action of acid and enzymes
Production of intrinsic factor, a glycoprotein needed for the absorption of vitamin B12 in the small intestine
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chyme
Ingested substances combine with the secretions of the glands of the stomach, producing a viscous, highly acidic, soupy mixture of partially digested food
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When the stomach is relaxed (empty), the mucosa has prominent folds called
rugae
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The mucosal layer (epithelium) is covered with
gastric pits containing gastric glands
Shallow depressions called gastric pits open onto the gastric surface